Synthesis of a 37-residue peptide amide corresponding to the entire amino acid sequence of alpha-form of rat calcitonin gene-related peptide (alpha-rCGRP).
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Amino Acid Sequence↗
Biomedical subjects
K Kitagawa
Publications and source records attributed to K Kitagawa.
[Electron microscopic studies on pits of the lens epithelium in the exfoliation syndrome].
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Aged↗
[Electron microscopic studies on the lens of exfoliation syndrome. II. On the non-exfoliated fellow eye].
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Aged↗
[Intraocular penetration of acyclovir after topical and systemic administration].
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Acyclovir↗
[Analysis of the oscillatory potentials of the normal rat electroretinogram by the maximum entropy method].
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Animals↗
Frequency of multiple primary cancers and risk factors for lung and breast cancer patients.
Among nearly 50,000 cancer patients at the National Cancer Center, about 2,000 have multiple primary cancer (MPC), and its frequency has been increasing in recent years. MPC is considered to be a reflection of severe exposure to carcinogens or of a predisposition to cancer, or sometimes it is thought to be an individual expression within familial aggregation. To clarify the roles of these proposed mechanisms, case-control studies and chromosome analyses, including fragile sites on chromosomes, were performed focusing in particular on breast and lung cancer patients. A histology-matched case-control study of multicentric lung cancer revealed a risk of cigarette smoking, which was also recognized in MPC in different sites among breast cancer patients, in addition to the radiotherapy. The frequency of heritable (rare) fragile sites among 87 lung cancer patients was more than double that of the general population, and the rare fragile site, 17q12, was clustered in the adenocarcinoma. The frequencies of heritable fragile sites among breast cancer patients were the same as the general population. MPC occurred in 10 of 87 lung cancer cases, and in 9 of 90 breast cancer patients; these individuals did not have heritable fragile sites. Heavy smoking and hazardous occupations were recognized in MPC cases with lung cancer, and a family history of rather rare cancers was also more common in MPC cases with breast cancer. One of three triple cancer cases had breast cancer as a feature in chromosomal aberrations of the peripheral blood lymphocytes, which may signify predisposition to cancer in these patients.
Breast Neoplasms↗
[Detection of platelet deposition in cases of arteriosclerosis obliterans (ASO) using indium-111 platelets and Tc-99m human serum albumin].
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Aged↗
[Feeding of patients (5)].
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Feeding Behavior↗
[Successful percutaneous drainage for infected cysts in polycystic kidney disease in a case of chronic hemodialysis].
A 60-year-old woman, who had been receiving chronic hemodialysis for chronic renal failure due to polycystic disease for 7 years, was admitted to our hospital with the chief complaints of right flank pain and high-grade fever on February 3, 1986. She had a family history of polycystic kidney disease and her elder sister has been undergoing chronic hemodialysis. The patient has had repeated episodes of urinary tract infection. The right markedly distended kidney was palpated with severe tenderness, and the performance status was poor. Computerized tomography showed the right kidney enlarging beyond the median line, but localization of the infected cysts was not clear. The 7-day intensive antibiotic therapy had no beneficial effect. On the 8th hospital day, percutaneous drainage, which was carried out for a large cyst with low-level echoes using ultrasonic guidance, yielded 600 ml of hemopurulent fluid. Bacterial culture of the aspirated fluid was positive for Escherichia coli. As the clinical symptoms did not improve after the 8th day, 10 Fr. catheter placement, percutaneous drainage and catheter placement were added for other cysts containing hemopurulent fluid. Although hematopyuria persisted, the patient became afebrile and the right kidney became smaller and softer. Both catheters were removed on the 30th hospital day. Repeated computerized tomography or ultrasonography revealed a few hyperdense or hyperechoic cysts in the right kidney. However, no recurrence of high-grade fever or right flank pain has been seen for 3 months. Ultrasonic-guided percutaneous drainage has a great potential for patient care of infected cysts in polycystic kidney disease.
Bacterial Infections↗
N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide is one of a new class of activators for Ca2+-activated, phospholipid-dependent protein kinase.
N-(6-Phenylhexyl)-5-chloro-1-naphthalenesulfonamide (SC-9) activated Ca2+-activated, phospholipid-dependent protein kinase (protein kinase C). SC-9 acted as a substitute for phosphatidylserine, which is one of the endogenous factors in activating protein kinase C. SC-9 was also effective in regulating the physiological functions at the whole-cell level. For example, SC-9 stimulated hexose transport activity in mouse fibroblasts, a protein kinase C-regulated cellular function. Thus, SC-9 may be useful to study the molecular basis of the regulation of protein kinase C activity, and the biological significance of this enzyme.
3-O-Methylglucose↗
Spectrally selective flash early receptor potential (ERP) in dichromats.
The human spectrally selective flash early receptor potential (ERP) was studied in 12 dichromats: 6 protanopes (12 eyes) and 6 deuteranopes (12 eyes). Color filters used were Kodak Wratten filters No.23A, No.57, and No.47 for the red, green, and blue flash ERPs, respectively. The ERP amplitude was measured between the summits of R1 and R2. Mean amplitudes of the red flash ERP and green flash ERP were highly significantly decreased in the protanopes (p less than 0.001) and deuteranopes (p less than 0.01) as compared with the corresponding data in 10 normal subjects (20 eyes). The mean amplitude of the blue flash ERP was significantly lower than normal (p less than 0.001) in the deuteranopes. The mean ratio of the blue flash ERP amplitude to the red flash ERP amplitude showed a highly significant increase in the protanopes (p less than 0.001) and a highly significant decrease in the deutoranopes (p less than 0.001) compared with the mean ratio in the normal subjects, indicating a new, useful index for the objective clinical detection of congenital color defects.
Adolescent↗
Possible involvement of protein kinase C in the stimulation of amino acid transport by phorbol ester, platelet-derived growth factor and A23187 in Swiss 3T3 cells.
Stimulation of amino acid transport induced by phorbol-12,13-dibutyrate, platelet-derived growth factor or A23187 was not observed in cells lacking protein kinase C. On the other hand, stimulation of transport by epidermal growth factor or insulin was not affected. These results suggested that the stimulation of amino acid transport is mediated by at least two separate pathways.
Amino Acids↗
Effect of protein kinase C activation and Ca2+ mobilization on hexose transport in Swiss 3T3 cells.
Down-modulation of Ca2+-activated, phospholipid-dependent protein kinase (protein binase C), which was accomplished by pretreatment with phorbol-12,13-dibutyrate for 24 h, resulted in the loss of a phorbol ester-induced stimulation of hexose transport activity in Swiss 3T3 cells. In these cells, however, platelet-derived growth factor as well as Ca2+ ionophore A23187 were still able to induce stimulation of hexose transport activity accompanied by the elevation of intracellular free Ca2+ concentration. Since chelation of extracellular Ca2+ inhibited this stimulation, inflow of extracellular Ca2+ into cytoplasm seemed to be essential for the stimulatory effect of platelet-derived growth factor and A23187 on hexose transport. Epidermal growth factor and insulin also stimulated hexose transport activity regardless of the absence of protein kinase C. However, in the case of epidermal growth factor, intracellular Ca2+, but not extracellular Ca2+, was found to be necessary for the stimulation. On the other hand, insulin stimulated the hexose transport independent of both intra- and extracellular Ca2+.
3-O-Methylglucose↗
Angiographic findings in two carcinoid tumors of the gallbladder.
Angiography was performed in 2 patients with carcinoid tumors of the gallbladder. In the first case, proper hepatic angiography revealed an obstruction and irregular neovascularization of the cystic artery and an encasement of the right hepatic artery. In the second case, celiac angiography revealed a dilatation and fine neovascularization of the cystic artery. In both cases, moderate hypervascular metastatic lesions were demonstrated in the liver. Although hypervascular metastases might suggest the diagnosis of metastasis from carcinoid tumor, the specific diagnosis of carcinoid tumor of the gallbladder must rely on the pathologic evidence.
Carcinoid Tumor↗
Marked hypervascularity and early arteriovenous shunting with portal vein filling in chronic relapsing pancreatitis.
Angiography was performed in 2 patients with chronic relapsing pancreatitis. Marked hypervascularity and early arteriovenous shunting with portal vein filling were demonstrated. Increased capillary vessels in the thickened capsule due to inflammation were observed in the pathologic specimen. The angiographic findings we report here are quite similar to those of pancreatic arteriovenous malformation.
Angiography↗
Influence of lesions of the limbic-hypothalamic system on metabolic response of pyruvate to daily repeated immobilization stress in rabbits.
The pyruvate metabolic response to the 1st exposure (exposure on the 1st day) to immobilization stress (IMO) were considerably altered by lesions of the periventricular arcuate nucleus (ARC), ventromedial hypothalamus (VMH), stria terminalis (ST) and dorsal fornix (FX). The pyruvate metabolic responses to IMO were completely abolished by seven times repetition of exposure to IMO in the rabbits with lesions of ARC and VMH; they were similar to sham-operated groups. In rabbits with lesions of ST and FX, the pyruvate metabolic responses to the 7th exposure (exposure on the 7th day) to IMO were almost the same as those after the 1st exposure to IMO, but these metabolic responses were completely abolished by the seven times repetition of exposure to IMO in the sham-operated animals. These results suggest that firstly the ARC, VMH, amygdala (AMYG)-ST system and dorsal hippocampus (HPC)-FX system are involved in the pyruvate metabolic responses to the 1st exposure to IMO, and secondly, that the AMYG-ST system and the HPC-FX system are involved in the disappearance process of pyruvate metabolic responses to IMO by the daily repetition of exposure to IMO.
Animals↗
Inhibition of the specific binding of 12-O-tetradecanoylphorbol-13-acetate to mouse epidermal membrane fractions by glycyrrhetic acid.
Glycyrrhetic acid inhibited the specific binding of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse epidermal membrane fractions in a dose- and time-dependent manner. Glycyrrhizic acid, a glycoside of glycyrrhetic acid, has no inhibitory effect on TPA binding. The results of kinetic analysis suggested that glycyrrhetic acid directly binds to the TPA receptor, resulting in the competitive inhibition of the binding of TPA to its receptor without affecting the number of binding sites (Ki = 2.2 X 10(-4) M). The inhibitory effect of glycyrrhetic acid on TPA binding to the membrane receptor may play a role in its antitumor-promoting activity in vivo.
Animals↗