Biomedical subjects

K Kisara

Publications and source records attributed to K Kisara.

At least 199 records · Page 11Linked to original sources

PubMed1975

[Central action of beta-phenylethylamine derivatives. (4) Effects on spontaneous motor activity and body temperature of beta phenylethyamine derivatives injected into the brain in reserpine pretreated mice].

Effects on spontaneous motor activity and body temperature of beta-phenylethlamine derivatives injected into the cerebral ventricles in reserpine or reserpine and isocarboxazide pretreated mice were investigated with the following results. 1) Each injection of tyramine (40 mug) and dopamine (40 mug) increased the spontaneous motor activity measured by the photo-cell counters method in reserpinized mice. 2) Each injection of tyramine (40 mug), dopamine (40 mug) and beta-phenylethylamine (40 mug) increased the spontaneous motor activity measured by both the wheel cage and photo-cell counters methods in reserpine and isocarboxazide-pretreated mice, but noradrenaline (20 mug) and isoproterenol (80 mug) did not increase the spontaneous motor activity as determined by both methods. 3) The injection of tyramine (40 and 80 mug), dopamine (10 and 40 mug) and p-octopamine (40 mug) increased the body temperature in reserpine and isocarboxazide pretreated mice. 4) Tyramine, dopamine and p-octopamine caused a marked increase in the body temperature as compared with control injection in reserpine and isocarboxazide-pretreated mice, whereas isoproterenol had no influence on body temperature. Our results suggest that beta-phenylethylamine derivatives have different effects in reserpinized and non-pretreated states.

Animals↗

PubMed1975

Effects of polyamines on the central nervous system.

Effects of polyamines on the central nervous system were studied in mice. Intraperitoneal administration of Spermidine (SPD) and Spermine (SPM) decreased spontaneous motor activity as measured by either the photo-cell counters method or the open-field test and lowered rectal temperature. A significant prolongation of sleeping time after pentobarbital was confirmed in small doses of SPD and SPM which had slight influence on spontaneous motor activity. The time to convulsion and death induced by strychnine was elongated by SPD and SPM. SPM in small doses inhibited writhing responses induced by 0.7% acetic acid. In addition, methamphetamine-induced hyperactivity and conditioned avoidance response were blocked by SPM in doses which decreased spontaneous motor activity. In all experiments, SPM appeared to have a powerful pharmacological activity compared with SPD. LD50 for SPD and SPM was 620 (500-769) mg/kg i.p. and 310 (200-480) mg/kg i.p., respectively.

Animals↗

PubMed1975

[Effect of beta-phenylethylamine derivatives on the central nervous system. II. Pharmacological effect of the intracerebral administration of metaraminol on the central nervous system].

Six hours after intracerebral administration, the central effects of metaraminol were examined with the following results. 1) Metaraminol in doses of 40 approximately 160 mug decreased spontaneous motor activity in mice as measured by the photo-cell counters method, the wheel cage method or the open-field test. Ptosis and catalepsy induced at these doses. 2) Metaraminol in doses of 40 approximately 80 mug which influenced the spontaneous motor activity in mice, blocked the avoidance behaviour but not escape. 3) Metaraminol in doses of 1.25 approximately 10 mug which did not influence the spontaneous motor activity in mice, markedly blocked the attaching response induced by the electroshock. 4) Ten min after intraventricular administration, metaraminol in a dose of 500 mug induced the arousal pattern of EEG in sensory cortex of cats and this pattern lasted for 30 min. Ninety min after administration, EEG tracings reverted to the drowsy pattern.

Aggression↗

PubMed1975

[Effect of beta-phenylethylamine derivatives on the central nervous system. III. Motor activity changes in mice due to the intracerebral administration of metaraminol].

Influence of metaraminol on behavioural changes in mice was studied with the following results. 1) When metaraminol was injected i.c., spontaneous motor activity as tested by either the photocell counters method or open-field test markedly increased within 90 min after injection, while on the contrary greatly decreased 3 hr later as compared with control group. Thus, these biphasic effects of metaraminol were clearly established. 2) 30 min after injection, metaraminol in doses of 160 mug did not alter brain catecholamines in mice, however, 6 hr after injection, brain dopamine and norepinephrine markedly decreased. 3) When metaraminol was injected into mice pretreated with reserpine of 6-hydroxydopamine, spontaneous motor activity tested by photo-cell counters method markedly increased and anti-6-hydroxydopamine activity of metaraminol was stronger than anti-reserpine. 4) Metaraminol completely antagonized ptosis and catalepsy induced by rerserpine. 5) Six hr after injection, anti-methamphetamine activity was observed.

Animals↗

PubMed1975

[Effects of beta-phenylethylamine derivatives on the central nervous system. (5) Changes in the volume of spontaneous movement in mice with intracerebral administration of tyramine].

Influence of tyramine (Ty) on behavioural changes in mice was studied and the following results obtained: 1) 30 min after Ty (160 mug, i.c.), brain noradrenaline and serotonin levels decreased while dopamine levels increased. 2) When Ty was injected i.c. into isocarboxazide (Iso) pretreated mice, spontaneous motor activity (SMA) measured by photo-cell counters method increased markedly but SMA by wheel cage method decreased. 3) When Ty was injected i.c. into Iso and p-chlorophenylalanine (p-CPA) (400 mg/kg, i.p., daily X 2) pretended mice, SMA measured by photo-cell counters method increased. While, SMA increased from 30 to 90 min after Ty, SMA measured by wheel cage method decreased till 30 min after Ty. 4) When Ty was injected i.c. into Iso and alpha-methyl-p-tyrosine (alpha-MPT) (125 mg/kg, i.p., daily X 2), SMA measured by photo-cell counters method decreased markedly when compared with Iso+saline treated group. When SMA was measured by wheel cage method, a difference between alpha-MPT+Iso-Ty treated group and Iso-saline group was not obtained. 5) When Ty was injected i.c. into p-CPA+alpha-MPT+Iso pretreated mice, SMA measured by photo-cell counters method did not show any increase compared with control group. 6) SMA produced by Iso-Ty in mice pretreated with haloperidol was significantly inhibited. A 50% dose of inhibition was seen with 0.3 mg/kg. From our results, it appears that an increase of SMA induced by Iso+Ty as revealed by the photo-cell counters method may be related to brain catecholamines and serotonin while a decrease of SMA in wheel cage method may be related to brain serotonin.

Animals↗

PubMed1974