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Biomedical subjects

K King

Publications and source records attributed to K King.

At least 109 records · Page 6Linked to original sources
PubMed1989

Computer-assisted linguistic analysis of two mentally retarded psychotic female's texts.

Prompted monologues from a schizophrenic and manic mentally handicapped female were analysed using a computer program designed to generate 118 syntactic variables. The procedure was repeated after several years. The linguistic profiles and their change over time were characteristic of chronic schizophrenia and mania, respectively: the schizophrenic-illness-based profile showed further linguistic disintegration; the manic-illness-based profile showed linguistic recovery, mirroring clinical improvement.

Adult↗
PubMed1987

The canine renal parathyroid hormone receptor is a glycoprotein: characterization and partial purification.

Covalent labeling of the canine renal parathyroid hormone receptor with [125I]bPTH(1-34) reveals several major binding components that display characteristics consistent with a physiologically relevant adenylate cyclase linked receptor. Through the use of the specific glycosidases neuraminidase and endoglycosidase F and affinity chromatography on lectin-agarose gels, we show here that the receptor is a glycoprotein that contains several complex N-linked carbohydrate chains consisting of terminal sialic acid and penultimate galactose in a beta 1,4 linkage to N-acetyl-D-glucosamine. No high mannose chains or O-linked glycans appear to be present. The peptide molecular weight of the deglycosylated labeled receptor is 62,000 [or 58,000 if the mass of bPTH(1-34) is excluded]. The binding of [125I]bPTH(1-34) to the receptor is inhibited in a dose-dependent fashion by wheat-germ agglutinin, but not by either succinylated wheat-germ agglutinin or Ricinus communis lectin, suggesting that terminal sialic acid may be involved in agonist binding. A combination of lectin affinity chromatography and immunoaffinity chromatography affords a 200-fold purification of the covalently labeled receptor.

Animals↗
PubMed1987

Induction of anesthesia with fentanyl or fentanyl plus etomidate in high-risk patients.

Anesthetic doses of fentanyl (46 +/- 1.3 micrograms/kg) and oxygen (group I) were compared to a moderate dose of fentanyl (3 to 4.7 micrograms/kg; mean = 3.54 +/- 0.1 micrograms/kg) + etomidate (0.4 mg/kg) intravenously (IV) (group II) during the anesthetic induction-endotracheal intubation sequence to evaluate hemodynamic changes and the incidence of side effects in 23 New York Heart Association class III and IV patients. Chest wall rigidity only occurred in group I (27%), and pain on injection (8%) and myoclonus (25%) only in group II. Patients in group I experienced transient, small increases in central venous pressure (immediately after induction) and mean pulmonary artery pressure (after tracheal intubation). Patients in group II had small, transient decreases in heart rate, mean arterial blood pressure and cardiac index after induction which returned to baseline levels immediately after tracheal intubation. The data indicate that a modest dose of fentanyl with etomidate is similar to a large (anesthetic) dose of fentanyl in terms of avoiding cardiovascular depression and preventing hemodynamic stimulation during and following the induction-tracheal intubation sequence. Our findings also demonstrate that these doses of fentanyl before etomidate decrease but do not eliminate side effects of etomidate. The results suggest that a modest dose of fentanyl followed by etomidate may be an attractive alternative to high doses of fentanyl in patients with limited cardiovascular reserve, especially when prolonged postoperative respiratory depression secondary to high doses of an opioid is undesirable.

Adult↗
PubMed1987

Computer-assisted linguistic analysis of an autistic adolescent's language: implications for the diagnosis of Aspberger's syndrome and atypical psychoses.

This study illustrates the use of a computer-assisted linguistic analysis technique to compare the spoken language of an adolescent, diagnosed in childhood as autistic, with that of normal and schizophrenic individuals. A distinctive profile, in keeping with accounts in the literature of autistic speech, was noted to be radically different from that found in linguistic analysis of schizophrenic speech. This distinctive profile was mirrored by her written linguistic analysis. Changes indicative of some improvement in language function were seen on re-recording after 5 years. Implications of this technique for differential diagnosis of Aspberger's syndrome and atypical psychoses are mentioned.

Adolescent↗
PubMed1987

Positive and negative symptoms of schizophrenia and linguistic performance.

Selected subjects from a group of first onset schizophrenics (aged under 30 years) were taken from a previous study and placed in one of two groups depending upon whether they had exclusively positive symptoms (n = 9) or a mixture of positive and negative symptoms (n = 9). Their linguistic profiles were compared with those of a group of controls (n = 10) matched for educational attainment and parental social class. Both groups of schizophrenics had significantly lower integrity scores, suggesting that they made more syntactic and semantic errors. Those patients who presented with negative symptoms tended to have speech of lower syntactic complexity than the other two groups, although the difference just failed to reach statistical significance. It is suggested that syntactic and semantic errors are state dependent features associated with positive symptoms, whereas low syntactic complexity may be a more enduring feature associated with the presence of negative symptoms.

Acute Disease↗
PubMed1986

Psychosocial aspects of juvenile rheumatoid arthritis.

The earliest studies dating back to the 1950s have tended to present a more pessimistic view of the psychosocial aspects of JRA patients. More carefully designed studies, however, have shown that these children do not have unique personality characteristics, nor are they necessarily socially maladjusted. Stress may play some role in onset of exacerbation of the disease, although this role is unclear at present. The child's level of cognitive development probably does play a role in the perception of pain and should be considered when undertaking patient education. The long-term psychosocial outcome of JRA patients appears to be quite good, with the majority of patients achieving educational levels at or beyond the level of the population as a whole and with the majority of patients able to support themselves. Future research may provide tools for even better assessment of this and other areas of psychosocial function.

Adaptation, Psychological↗
PubMed1986

Topical azelaic acid and the treatment of acne: a clinical and laboratory comparison with oral tetracycline.

Topical azelaic acid and oral tetracycline were compared in a 6-month double-blind study for treatment of acne vulgaris in 45 male subjects with clinical acne. Their acne was graded, inflamed or non-inflamed, lesions were counted and the density of their skin microflora was measured. Both treatments were of benefit and produced only a few minor side-effects. Although oral tetracycline was more effective than azelaic acid, the differences were only just significant. The average reduction in numbers of cutaneous micrococcaceae and Propionibacterium sp. with azelaic acid treatment was 224 and 30-fold, respectively. In a separate group of 11 male subjects with physiological acne the effect of azelaic acid on sebum excretion rate was assessed, and little change was detected.

Acne Vulgaris↗