[Evaluation of intraperitoneal perfusion of COPP in peritonitis carcinomatosis].
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Adult↗
Biomedical subjects
K Kikuchi
Publications and source records attributed to K Kikuchi.
Late-phase enhancement of the upstream portion of pancreatic adenocarcinoma on dual-phase helical CT.
BACKGROUND: Late-phase enhancement of pancreatic parenchyma upstream (tail side) of pancreatic adenocarcinoma is found frequently on dual-phase helical computed tomography (CT). We measured the frequency of late-phase enhancement of the upstream portion of pancreatic adenocarcinoma and normal pancreatic parenchyma using dual-phase helical CT. METHODS: Twenty-one patients with pancreatic adenocarcinoma and nontumorous pancreas upstream of tumors were compared with 100 control patients without pancreatic disease. Early and late scans started at 25 and 75 s, respectively, after intravenous injection of contrast material. The attenuation values of normal and nontumorous pancreas upstream of tumors were assessed in three phases: precontrast, early, and late enhanced. Enhancement ratio (ER) was calculated as ER = (late phase - precontrast)/(early phase - precontrast). RESULTS: Late-phase enhancements (ER > 1.0) were seen in 86% of upstream pancreas and 10% of normal pancreas. The mean ER of upstream pancreas was significantly higher than that of normal pancreas (p < 0.01). CONCLUSION: Late-phase enhancement of the pancreas upstream of the tumor is frequently observed in patients with pancreatic adenocarcinoma. Late-phase enhancement and histology showed a correlation for chronic obstructing pancreatitis in five patients.
Adenocarcinoma↗
Clinical significance of antinuclear matrix antibody in serum from patients with anti-U1RNP antibody.
Serum containing anti-U1RNP antibodies reacts with the nuclear matrix, the relatively insoluble component of the cell nucleus, in addition to U1RNP. In this study, we determine the serum titer and clinical correlations of antinuclear matrix antibodies in samples from patients with anti-U1RNP antibodies. The patients with anti-U1RNP antibodies were classified as having mixed connective tissue disease (MCTD, 15 patients), systemic sclerosis (SSc, 12 patients), systemic lupus erythematosus (SLE, 7 patients), and undifferentiated CTD (UCTD, 9 patients). Antinuclear matrix antibodies were detected using indirect immunofluorescence staining on HCl-treated HEp-2 cells. The antinuclear matrix antibody titer was significantly higher in serum from patients with MCTD or SSc than in serum from patients with SLE or UCTD. The antinuclear matrix antibody titer was significantly increased in serum from patients with sclerodactyly, pitting scars, contracture of the phalanges, and decreased carbon monoxide diffusion capacity. Thus, a higher titer of antinuclear matrix antibodies in serum from patients with anti-U1RNP antibodies may be associated with a clinical diagnosis of MCTD or SSc rather than a diagnosis of SLE or UCTD.
Adolescent↗
Diffuse white matter lesions associated with herpes simplex encephalitis as observed on magnetic resonance imaging.
A 2-year-old boy with herpes simplex encephalitis developed diffuse brain lesions involving the white matter of both cerebral hemispheres. These lesions in the white matter were clearly observed on magnetic resonance imaging (MRI) with the T2-weighted sequence, and were found to have spontaneously disappeared on subsequent MRI performed 7 weeks later. Brain lesions associated with herpes simplex encephalitis in the literature are reviewed and the pathogenesis in the present case is discussed.
Brain↗
Synthesized image processing in clinical neurosurgery.
In an effort to achieve efficient image management in clinical neurosurgery utilizing a local image filing system (EFPACS, Fuji Electric Co., Ltd), adequate image-processing and display techniques were developed. One is a method whereby the anatomical location of the thalamic and basal ganglion lesions is determined by automatically superimposing these lesions defined by magnetic resonance imaging (MRI) directly onto the Schaltenbrand-Wahren's human brain atlas. Horizontal, coronal and sagittal MR images are initially obtained based on the intercommissural line and a perpendicular erected on the midcommissural point as the basic reference coordinates. Precise superimposition is accomplished by the use of these reference axes. This imaging technique may offer the potential for help in anatomical identification of small intracranial lesions. Another technique described in the current communication is automated synthesis of two cerebral angiograms. By simply indicating two reference points, nasion and inion, with a cursor on the display screen, two films are automatically superimposed and displayed as a single synthesized image, featuring two different vascular phases simultaneously by a positive(vein)-negative(artery) mode. This technique was applied to patients with complete occlusion of the middle cerebral artery with or without sufficient blood flow through collateral circulation and was found useful in evaluating basic hemodynamics on a single angiographic image.
Aged↗
Huge sellar chordoma: CT demonstration.
The authors report the computed tomographic (CT) findings in a patient with an unusual large intracranial chordoma involving the midline sellar region. This rare intracranial tumor is reviewed in the literature, and in particular the values of CT evaluations are detailed in the presented case with a special reference to differential diagnosis of the tumors in and around the sella turcica.
Chordoma↗
Computed tomography of an intracranial lipoma confined in the suprasellar cistern.
A case of large intracranial lipoma involving the suprasellar cistern is presented in a 50-yr-old man with a history of occipital headaches. Evaluations by routine computed tomography (CT) combined with metrizamide CT cisternography were extremely useful in the diagnosis of this rare condition. Intracranial lipomas are reviewed in the literature and the role of CT evaluations is discussed.
Brain Neoplasms↗
Orbital hemangiopericytoma: CT, MR, and angiographic findings.
A case of orbital hemangiopericytoma is reported in a 20-yr-old man presenting with decreased vision and painless proptosis of the left eye. This rare orbital tumor is reviewed in the literature, and in particular the neuroradiological findings, including those of computerized tomography (CT), magnetic resonance imaging (MRI), and angiography are detailed in the presented case. MRI was found to be useful both in delineating precise anatomical relationships between the optic nerve and the tumor, and in differentiating from cavernous hemangiomas, the most common vascular tumors of the orbit, with the combination of CT and angiography.
Adult↗
Comparison between nonpulsatile and pulsatile machine perfusion preservation in liver transplantation from non-heart-beating donors.
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Alanine Transaminase↗
Effectiveness of bactobolamine as a new immunosuppressive agent.
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Animals↗
Expression of syndecan-1 is common in human lung cancers independent of expression of epidermal growth factor receptor.
In order to determine syndecan-1 expression in lung cancer, we examined 115 lung cancer specimens and 17 lung cancer cell lines. Syndecan-1 was immunohistochemically stained with a polyclonal antibody in 115 paraffin-embedded specimens; 84 cases out of 97 non-small cell lung cancer (NSCLC) and eight cases out of 18 small cell lung cancer (SCLC) were positively stained. Simultaneously, epidermal growth-factor receptor (EGFR) was stained; 47 cases out of 97 NSCLC and one case of 18 SCLC were positively stained. No significant correlation was shown between EGFR and syndecan-1 expression (P=0.68). Syndecan-1 mRNA was detectable in 16 of 17 lung cancer cell lines and EGFR mRNA in nine of 17. Eight cell lines had syndecan-1 mRNA as well as EGFR mRNA. PR-39 (1 microM) and 80 pM transforming growth factor-beta(1) (TGF-beta(1)), did not increase expressions of syndecan-1 mRNA and EGFR in five lung cancer cell lines. We concluded that lung cancer had detectable syndecan-1; however, expression of syndecan-1 protein did not correlate with survival time of lung cancer patients.
Aged↗
Massive hemoptysis due to Mycobacterium fortuitum infection controlled with bronchial artery embolization - a case report.
We reported a case of first reported pulmonary infection due to Mycobacterium fortuitum (M. fortuitum) with massive hemoptysis, successfully treated by bronchial artery embolization (BAE). A 78-year-old male was admitted to our hospital complaining of massive hemoptysis. A biochemical examination and DNA/DNA hybridization revealed M. fortuitum in the culture of his sputum. He was treated by BAE, and antituberculous agents and levofloxacin. The patient remains well without recurrence more than one and a half years after the admission.
Aged↗
Innovative pharmacologic approaches to cardiopulmonary resuscitation.
The survival rate of patients undergoing cardiopulmonary resuscitation is 5 to 15%. New cardiopulmonary resuscitation treatment approaches under investigation include the use of vasopressin as a vasopressor, amiodarone for the treatment of ventricular tachyarrhythmias, and adenosine antagonists (i.e., theophylline) for bradyasystolic rhythms. More innovative approaches include the use of thyroid hormone and endothelin.
American Heart Association↗
Effects of stress on growth of transplanted hepatic tumours and immune responses.
Growth of transplanted hepatic tumours (T-9) was enhanced in immune rats under stress, compared with immune rats in an unstressed condition. Compared with unstressed immune rats, killer activity of mononuclear cells infiltrating the tumours against T-9 cells was significantly reduced in stressed immune rats. In contrast, killer activity of splenocytes obtained from stressed immune rats against T-9 cells was elevated compared with that from unstressed immune rats. In addition, natural killer cell activity of mononuclear cells infiltrating the tumours obtained from stressed immune rats was significantly reduced compared with that from unstressed immune rats. Cell populations infiltrating tumour tissues were identified by flow cytometric analysis. The percentage of CD8+ cells in mononuclear cells isolated from tumour tissues of stressed immune rats was reduced compared with that of unstressed immune rats. Furthermore, interleukin-2 responsiveness of splenocytes was suppressed in stressed immune rats, whereas T cell function as reflected by phytohaemagglutinin- or Concanavalin A-reactivity was unaffected by stress. Collectively, it is likely that stress suppressed the generation of cytotoxic cells from the spleen cells of immune rats.
Animals↗
Method for estimating the intensity of scattered radiation using a scatter generation model.
An analytical formula for estimating the intensity of scattered radiation in an x-ray image under various exposure conditions has been developed. The formula was derived using measured data of scatter and primary intensity for various exposure conditions. To simplify the formula, a scatter generation model was constructed mathematically which assumes that the scattered fluence in a material depends on three processes: (1) scattering of the primary photons; (2) scattering of previously scattered photons; and (3) attenuation of the scattered photons. Using this model, the dependence of scatter-to-primary ratio on phantom thickness and the tube voltage was expressed by a simple equation. Parameters included in the model were determined from the analysis of measured data. Based on empirical data, it was assumed that the dependence of scatter-to-primary ratio on air gap and field size is not affected by variations of phantom thickness and tube voltage. The final formula, which does not include the term of phantom thickness, gives an estimate of the intensity of the scattered radiation from exposure conditions. The scatter intensity estimated using the formula was compared with measured data for various phantom thicknesses, tube voltages, air gaps, and field sizes; the results show that the intensity of scattered radiation can be estimated within about +/- 10% using predetermined parameters.
Mathematics↗
A technique of scatter-glare correction using a digital filtration.
A scatter-glare correction technique for x-ray images acquired with an antiscatter grid was developed. In the technique, the scatter-glare image was estimated from exposure conditions and subtracted from the acquired image. The basic procedure in the estimation of the scatter-glare image is convolution filtering; however, the novel aspects of the technique are as follows: (1) To estimate the scatter-glare intensity, a formula that does not include the term of object thickness was used. With this formula, the correction can be performed, even for nonuniform phantoms; (2) To estimate the scatter-glare distribution, the experimental scatter-glare point spread function (PSF) was directly used as a convolution kernel. Although the shape of the PSF changed slightly for water thicknesses of 5-25 cm, we applied the PSF measured at a water thickness of 15 cm to the correction experiments. For the stepped water phantom (10-20 cm), scatter-glare estimation produced an average error of 10%, with respect to the lead bar data. Furthermore, the improvement of image quality and quantitative accuracy resulting from the correction was examined.
Biophysical Phenomena↗
Immunohistochemical detection of estrogen receptor in invasive human breast cancer: correlation with heat shock proteins, pS2 and oncogene products.
The authors immunohistochemically studied the expression of the estrogen receptor (ER), 27-kD heat shock protein (HSP27) and pS2 in 118 invasive primary human breast cancers. Positive nuclear staining of the ER was detected in 64% of the cases and was closely correlated with the biochemical assay (p < 0.0001). ER-positive tumors were significantly decreased with tumor size and stage (p < 0.001 each), but not with lymph node status. Positivity of the ER was correlated with the cytoplasmic expression of HSP27 (p < 0.005), pS2 (not significant) and HSP70 (not significant). ER negativity was significantly correlated with the expression of p53, epidermal growth factor receptor (EGFR) and c-erbB-2 (p < 0.05 each). Thus, it was concluded that ER-positive breast carcinomas, relatively small in size, preferentially expressed HSP27, HSP70 and pS2 and that ER-negative tumors, relatively large in size, were predisposed to express p53, EGFR and c-erbB-2.
Breast Neoplasms↗
Pentoxifylline potentiates the antitumor effect of cisplatin and etoposide on human lung cancer cell lines.
The effect of pentoxifylline (PENT) on the sensitivity of two human lung adenocarcinoma cell lines, PC-9 and PC-14, to cisplatin (CDDP) and etoposide (ET) was studied. PENT at 0.5 and 1 mM enhanced the cytotoxicity of CDDP and ET on PC-14 and PC-9, respectively. Isobologram analyses of IC50 data, as well as combination index calculations, revealed that PENT had an additive or a synergistic effect when applied in combination with CDDP or ET, respectively. PENT potentiated the antitumor effect of ET in a nude-mouse xenograft model using PC-14 cells, when PENT was administered at 150 mg/kg subcutaneously for 6 days. Flow cytometry revealed that PENT decreased the accumulation of cells in the G2+M phase caused by CDDP when using PC-9 cells. However, PENT did not remarkably alter the accumulation of cells in G2+M caused by ET. These results suggest that PENT enhanced the antitumor effects of CDDP additively and those of ET synergistically. The enhancement mechanism probably differs between CDDP and ET. PENT needs more study to elucidate its potency as a new agent for combination chemotherapy.
Adenocarcinoma↗