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Biomedical subjects

K Kikuchi

Publications and source records attributed to K Kikuchi.

At least 1,225 records · Page 68Linked to original sources
PubMed1983

[Immunohistological studies on the identification of T cells and T cell subsets infiltrating in human stomach cancer tissues].

T cells and T cell subsets in human gastric cancer tissues were identified using the immunoperoxidase technique with anti-T cell monoclonal antibodies (Leu-1, Leu-2, Leu-3 and Leu-4), anti-HLA-DR(Ia) monocronal antibody, and anti-Ig sera. The majority of lymphocytes infiltrating into gastric cancer tissues were Leu-1 and Leu-4 positive T cells; they consisted of a Leu-2 positive T cell subset (Tc/s) and a Leu-3 positive T cell subset (Th/i). Leu-2 positive T cells infiltrated the gastric cancer tissues of 6 patients with a moderate or marked degree of lymphocyte infiltration; Leu-3 positive T cells infiltrated these tissues of 11 patients. These results show that the degree of T cell and T cell subset infiltration may effect the host-tumor relationship.

Adenocarcinoma↗
PubMed1983

B-cell malignancies and differentiation antigens defined with monoclonal antibodies.

Monoclonal antibodies directed to B-cell lineage were produced. They were characterized by their reactivity with a variety of human hematopoietic cell lines and normal lymphoid cells and by the immunohistological distribution of cells positive for the antibodies. Some of them were specific for B-cell lineage at various stages of B-cell differentiation and some were, in addition, cross-reactive with other cell lineages. These newly produced antibodies were utilized to dissect and characterize B-cell malignancies and were applied for classification of B-cell malignancies.

Animals↗
PubMed1983

[Diagnosis and classification of hematologic tumors using anti-lymphocyte monoclonal antibodies].

Many hybridoma monoclonal antibodies to lymphocytes of T cell and B cell lineage and of both T and B cell lineage and stem cells were newly developed and characterized. Lymphocyte surface antigens that appear at the specific stages of T and B cell differentiation were clearly detected by these monoclonal antibodies. These antigens were also expressed on the cell surface of lymphatic leukemias and malignant lymphomas, suggesting the differentiation stages from which the tumor was derived. Leukemias and malignant lymphomas were diagnosed and classified objectively with these monoclonal antibodies. Immunohistochemical approach with the antibodies was very helpful for diagnosis of malignant lymphomas. Since the cell surface phenotypes are often related to biological behavior of the cell, the classification was expected to reflect the pathologic expression of tumor cells, and to have relationship with the clinical course of the patients with lymphoid malignancies. In fact, it has been suggested that the classification of leukemia and lymphoma based on the antigens defined by the monoclonal antibodies is related to the clinical features and prognosis of the patients.

Antibodies, Monoclonal↗
PubMed1983

[Endobronchial metastasis of testicular embryonal cell carcinoma--a case report].

Four cases of endobronchial metastasis in testicular embryonal cell carcinoma have been reported in the literature. We now present a new case, a 39-year-old male who underwent right orchiectomy for testicular embryonal cell carcinoma. Ten months later, tumor like shadows were identified in the left upper lobe on a follow up chest X-ray. Bronchoscopy revealed an endobronchial tumor mimicking a bronchogenic carcinoma in the left superior posterior bronchus. A metastatic embryonal cell carcinoma of the testis was histologically diagnosed. Left upper lobectomy was performed, and the patient is still alive 11 months thereafter.

Adult↗
PubMed1983

[Clinical evaluation of cefroxadine in surgical infections].

Cefroxadine (CXD), a new cephalosporin, was orally administered to 22 cases in total; 5 with wound infection, 4 with felon, 3 with acute pyelonephritis, 2 with furuncle, 2 with infected atheroma, 2 with phlegmone, 2 with abscess, 1 with acute mastitis, and 1 with lymphadenitis. The daily dose was 500 to 1,000 mg, and maximal total dose and duration was 5 g and 5 days, respectively. Therapeutic results were good in 20 cases (effectiveness rate: 91%), fair in 1 and poor in 1. No side effect was observed in all cases among 22 patients with CXD.

Administration, Oral↗
PubMed1983

[Experimental and clinical studies of latamoxef in intestinal surgery].

After the intravenous administration of 1.0 g of latamoxef (LMOX), the concentration of LMOX were determined in normal intestinal tissue and serum of 17 patients underwent surgery for intestinal problems, and the results obtained were as follows. At 60 approximately 150 minutes after administration, the levels of LMOX were 37.5 approximately 26.3 micrograms/ml in serum and 14.8 approximately 10.5 micrograms/g in normal intestinal tissues. This values were enough to inhibit the growth of Gram-negative bacteria caused for some postoperative wound infections. For intravenous administration of 1.0 g of LMOX just before operation, no wound infection was observed in 13 patients with large intestinal cancer and 4 patients with benign intestinal disease.

Adult↗
PubMed1983

[Clinical study on drip infusion of micronomicin in the fields of surgery and gynecology].

The drip infusion of micronomicin (MCR) in the field of surgery and gynecology was investigated. MCR was administered by drip infusion to 73 cases of surgical diseases and 31 cases of gynecological diseases. The clinical effective rate of MCR alone was 68% in all cases and that of MCR combined with other antibiotics was 89%. No remarkable side effect of drip infusion of MCR was found in all cases. Drip infusion of MCR was found to be as effective and safe as intramuscular injection of the antibiotic.

Adolescent↗
PubMed1983

[Determination of urinary immunosuppressive acidic protein in cancer patients].

The urine levels of immunosuppressive acidic protein (IAP) were measured in patients with and without cancer, using passive hemagglutination inhibition test and 24-h urine samples. In 23 control healthy adults, the urine levels of IAP were 0.13-1.3 mg/day. If an elevation of IAP levels were found in 46 (48%) of 96 cancer patients. Elevated urine IAP levels were found in 6 (18%) of 34 patients with non-cancerous gastrointestinal tract diseases. Increased urine IAP was demonstrated in 11 (58%) of 19 non-cancer patients with rheumatoid arthritis.

Adolescent↗
PubMed1983

[Clinical studies on micronomicin treatment for surgical infections].

The clinical effects of micronomicin (MCR, Sagamicin) treatment for 10 patients with surgical infections were investigated and following results were obtained. 1. Clinical effectiveness Of 10 patients treated with MCR, the results were good in 7 cases, poor in 3 cases. 2. Side effects of MCR No significant side effects were observed in 10 patients treated with MCR.

Adolescent↗
PubMed1983

Bifid tail of the pancreas: a case presenting as a gastric submucosal tumor.

A 49-yr-old male was admitted to our hospital because of epigastric discomfort and a suspected tumor of the stomach on barium meal examination at the Center for Automated Multiphasic Health Test and Services. The tumor shadow of the stomach was initially considered as the "type II" gastric carcinoma according to the Borrmann's classification. Multiple endoscopical and electrocautery cutting biopsies revealed that the tumor occurred in the submucosal layer and was composed of normal pancreatic tissue. A computed tomogram showed a large mass on the pancreatic body which was adjacent to gastric wall. Selective angiography of the celiac trunk revealed that the gastric submucosal lesion was supplied by the transverse pancreatic artery. Endoscopic retrograde pancreatography showed that Wirsung's duct had a divergence in the body of the pancreas and one of the branched ducts headed for the posterior wall of the gastric body. On the basis of these results, a diagnosis was made of the rare pancreatic anomaly, "bifid tail of the pancreas." One of the tails formed the gastric submucosal tumor. This report emphasizes the potential diagnostic value of combined study of endoscopic retrograde pancreatography and computed tomography in determining the presence of pancreatic anomaly.

Cholangiopancreatography, Endoscopic Retrograde↗
PubMed1982

Nasal T-cell lymphoma as a type of so-called "lethal midline granuloma".

Six cases were described in which an initial clinical diagnosis of "rhinitis gangrenosa progressiva" or lethal midline granuloma was made. The histological examinations of their surgical and autopsy specimens proved that their nasologic diseases could all be identified as malignant lymphoma arising from the nasal cavity, showing the general histologic characteristics reported for T-cell lymphomata derived from peripheral T-cells. This histologic observation was then confirmed by immunofluorescence studies using various antisera directed toward either human T- or B-cell-surface antigens. These studies clearly demonstrated that their malignant cells bore human Ly-l-like antigen but lacked human TL-like and Ia-like antigens as well as surface-bound immunoglobulins, indicating their peripheral T-cell origin. These data may suggest that so-called "rhinitis gangrenosa progressiva" or lethal midline granuloma contains at least two distinct disease categories, one of which is Wegener's granulomatosis, and the other of which is nasal T-cell lymphoma as described herein.

Antigens, Neoplasm↗