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Biomedical subjects

K Keczkes

Publications and source records attributed to K Keczkes.

At least 37 records · Page 2Linked to original sources
PubMed1983

The outcome of primary irritant hand dermatitis.

Four hundred and sixty-two patients suffering from primary irritant hand dermatitis were sent postal questionnaires after 1-16 years regarding the outcome of their dermatitis. Two hundred and thirteen patients replied (a compliance rate of 46%). Of the 213 replies 188 were accepted for analysis, of whom only 58 (30.8%) had complete remission of their dermatitis, whilst 130 patients (69.2%) had continuous, or intermittent disease. Of sixty-four patients who changed their occupation only twenty-one (32.8%) had complete remission of their dermatitis as opposed to thirty-seven (29.8%) of 124 who continued their occupation after the diagnosis of primary irritant hand dermatitis was made. It would appear that the outcome of primary irritant hand dermatitis is not favourable, even after 10 years, and change of occupation has no significant effect.

Dermatitis, Contact↗
PubMed1980

Do corticosteroids prevent post-herpetic neuralgia?

Forty otherwise healthy patients over 50 years of age with early, severe painful herpes zoster were randomly allocated to two groups for treatment. Twenty patients received prednisolone 40 mg daily with gradual reduction over a period of 4 weeks, whilst the other twenty patients received carbamazepine 100 mg four times daily. Thirteen of the twenty patients (65%) in the carbamazepine treated group developed post-herpetic neuralgia lasting up to 2 years, whilst only three of the twenty prednisolone treated patients (15%) had post-herpetic neuralgia lasting up to 6 months only. Thus the incidence and duration of post-herpetic neuralgia were considerably redudced in the prednisolone treated group. In neither group did disseminated zoster or other complications occur.

Aged↗
PubMed1979

The Shulman syndrome: report of a further case.

A 53-year-old woman developed swelling of her hands after strenuous sport. Soon her feet became affected and the swelling spread up the arms and legs making arm movement and walking difficult. No Raynaud's phenomenon appeared or other features of systemic sclerosis. There was eosinophilia and hypergammaglobulinaemia in the peripheral blood. Histological examination of the skin showed an increase in the collagen bundles in the dermis extending down to the adipose tissue. The fascia showed dense fibrous tissue with a perivascular infiltrate of lymphocytes, a few plasma cells and eosinophils. Immunohistology of the skin and fascia were negative for IgA, IgG, IgM, C3, CIq and fibrin. After 4 weeks of prednisolone 40 mg daily there was a great improvement. This continued with further corticosteroid therapy.

Edema↗
PubMed1979

Pernicious anaemia and granulomatous skin lesions in a case of common variable hypogammaglobulinaemia.

A 45-year-old woman is reported with a history of recurrent bacterial infections since childhood; at the age of 37 years she developed recurrent ulcerated lesions around her mouth, in the groins and buttocks, which histologically contained small, non-caseating granulomas. A year latter when being treated for empyema, she was found to have common variable hypogammaglobulinaemia. Three years after this she developed a megaloblastic anaemia of vitamin B12-deficiency type.

Agammaglobulinemia↗
PubMed1978

Plasma cortisol values after topical application of diflucortolone valerate (0.3%) or clobetasol propionate (0.05%) in psoriatic patients.

A double-blind randomized study to compare the plasma cortisol values at both 9.00 a.m. and 12 midnight following topical application fo 10 g daily for 7 days of either diflucortolone valerate 0.3% (Nerisone Forte) ointment or clobetasol propionate 0.05% (Dermovate) ointment in 20 hospital inpatients suffering from severe psoriasis, showed that clinically both compounds behaved as potent, highly active topical preparations and caused rapid clinical improvement. Diflucortolone valerate 0.3% caused only slight and non-significant depression of mean plasma cortisols. On the other hand, clobetasol caused an immediate, persistent and statistically significant depression of the 9.00 a.m. coritsol values, which appeared to recover towards normality only on the third day after therapy had been withdrawn. the difference between these 2 compounds was found to be statistically significant (P less than 0.05). From these observations, it is concluded that diflucortolone valerate 0.3% ointment suppresses adreno-cortical function to a significantly lesser extent than clobetasol propionate 0.05% ointment.

Adrenal Cortex Hormones↗
PubMed1977

REM syndrome (reticular erythematous mucinosis): report of a further case or variant of it.

A 50-year-old woman had cervical lymphadenopathy, swollen and waxy-looking gums, and a diamond-shaped, reticular erythematous eruption on her back of eight years' duration. Histologic examination of the gingival tissue and skin showed round-cell infiltration around the small blood vessels and in the upper part of the dermis, and an extensive eosinophilic amorphous deposit throughout the dermis that stained with Alcian blue. The clinical and histologic features, although not identical, resembled those reported by Lischka and Orthenberger (1972) and later by Steigleder et al (1974).

Adult↗
PubMed1976

Bullous dermatosis of chronic renal failure.

Four of five patients with chronic renal failure developed tense bullae on the backs of their hands and fingers. In one of these patients the bullae were more widespread. In the fifth patient the lesions were limited to the fingers. The clinical picture resembled that of porphyria cutanea tarda, but porphyrin studies were consistently within normal limits. Histological studies showed subepidermal pressure bullae in each patient. In one of the patients immunohistology showed greenish fluorescence at the bases of the dermal papillae.

Adult↗
PubMed1976

Wegener's granulomatosis. Combined therapy with low-dosage systemic corticosteroids, azathioprine and cyclophosphamide in three patients.

Three patients with Wegener's granulomatosis are reported. All three had skin, nose, sinus, mouth and pulmonary lesions; one had severe renal involvement as well. In two patients combined treatment with low-dosage systemic corticosteroids, azathioprine, and cyclophosphamide resulted in rapid clinical improvement and complete disappearance of the skin, mouth, nasal, sinus and pulmonary lesions. In one of these two patients who had severe renal involvement, proteinuria greatly diminished and arrest of progression of renal insufficiency was observed. In the third patient combined treatment with azathioprine and cyclophosphamide resulted in complete remission of skin, mucous membrane, lung and sinus lesions. The patient with severe renal involvement is alive and ambulant 4 years after the onset of the disease, the other two are completely symptom-free and well 2 1/2 years and 1 year after the onset of their illnesses, respectively. These results confirm previous reports about the effectiveness of immunosuppressive and cytotoxic agents in Wegener's granulomatosis, the use of which seems to have improved the prognosis significantly in a disease previously considered to be fatal within 5 months.

Adrenal Cortex Hormones↗
PubMed1976

Hexahydro, 1,3,5, tris (2-hydroxyethyl) triazine, a new bacteriocidal agent as a cause of allergic contact dermatitis.

During the investigation of an outbreak of dermatitis in a medium-sized engineering works, the authors discovered four patients with allergic contact sensitivity to hexahydro,1,3,5, tris (2-hydroxyethyl) triazine, (Grotan), a new bacteriocidal agent used in coolant liquids. The authors failed to find any published report on this subject and would like to draw attention to Grotan as a new potential sensitizer.

Adult↗
PubMed1976

Malignant hepatoma associated with acquired hepatic cutaneous porphyria.

A 60-year-old woman with a three-year history of an acquired hepatic cutaneous porphyria was discovered to have a porphyrin-producing malignant hepatoma. An attempt was made to treat her with fluorouracil perfused through a hepatic artery catheter. It did not produce shrinkage of the tumor, but the patient remains alive and ambulant a year after the infusion, although her skin lesions (scarring, bulla formation, and hyperpigmentation) on the fingers, back of hands, and face persist and she continues to excrete abnormally high quantities of porphyrin in her feces.

Carcinoma, Hepatocellular↗