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Biomedical subjects

K Katoh

Publications and source records attributed to K Katoh.

At least 307 records · Page 17Linked to original sources
PubMed1982

Hydralazine and furosemide kinetics.

Fursosemide kinetics were studied in 25 patients with congestive heart failure. The elimination half-life (t1/2) was longer and the elimination rate constant and the plasma clearance smaller in patients with advanced (n = 15) than in those with moderate (n = 10) failure. Furosemide kinetics with and without hydralazine were compared in eight patients with advanced heart failure. Furosemide t1/2 patients receiving both drugs fell from 96 +/- 16 to 81 +/- 15 min (P less than 0.02), elimination rate constant increased from 0.0186 +/- 0.0056 to 0.0214 +/- 0.0068 min -1 (P less than 0.05), and plasma clearance rose from 72.6 +/- 18.5 to 88.1 +/- 26.9 ml/min (P less than 0.01). Renal clearance rose from 45.4 +/- 12.0 to 60.9 +/- 19.0 ml/min (P less than 0.01) and creatinine clearance was unchanged. We conclude that hydralazine affects furosemide kinetics.

Adult↗
PubMed1981

[Clinical evaluation of pivmecillinam in the maintenance therapy of chronic urinary tract infection (author's transl)].

In order to evaluate the efficacy and safety of pivmecillinam (melysin tablet, PMPC), PMPC was administered to 78 chronic UTI cases in the field of obstetrics and gynecology (posthysterectomy infection, chronic cystitis, chronic pyelonephritis and etc.). In principle, daily 400 mg of PMPC was administered for 2 weeks. (1) Overall clinical efficacy judged by doctor was evaluated in 78 cases and the result was; excellent in 17, good in 37, fair in 10, poor in 13 and unknown in 1 case with the effectiveness rate of 69.2%. (2) Overall clinical efficacy judged by 'criteria for clinical evaluation in complicated UTI' recommended by UTI study member was evaluated in 54 cases and the result was; excellent in 15, good in 20 and poor in 19 cases with the overall efficacy rate of 64.8%, the result of which was similar to that of doctor's judgement. (3) Efficacy on pyuria was evaluated in 72 cases and it was cleared in 27, decreased in 25, unchanged in 20 and unknown in 6 cases. Efficacy on bacteriuria was evaluated in 72 cases and it was eliminated in 44, decreased in 9, replaced in 8, unchanged in 8 and unknown in 9 cases. (4) Side effect, considered by doctors to be caused by PMPC administration, was noticed in 3 out of 78 cases (3.8%), all of which was mild gastrointestinal disturbance and the administration of PMPC was continued. Abnormal change of laboratory finding considered by doctors to be caused by PMPC administration was noticed in 1 out of 78 cases, which was slight elevation of GOT and GPT values. It is therefore considered that PMPC appear to be useful drug for the maintenance therapy of chronic UTI in the field of obstetrics and gynecology.

Adult↗
PubMed1980

Physiological and light-electron microscopical studies of parietal cells and G cells before and after selective vagotomy with pyloroplasty.

The function of residual parietal cells and G cells following selective vagotomy with pyloroplasty (SV + P) in 21 duodenal ulcer patients was assessed by light-electron microscopical studies of gastroendoscopic biopsy material and determination of gastric acid secretion and serum gastrin levels. The postoperative decrease in number of parietal cells was not so great when compared with the reduction of acid secretion. However, the ultrastructural changes of parietal cells suggested hypofunction of the cells. In addition, the response of parietal cells to histalog stimulation was also decreased according to morphological observations under electron microscope. Basal plasma gastrin was significantly increased (p < 0.01) one month after surgery. Integrated gastrin response (IGR) to meat extract and insulin hypoglycemia stimulation was also increased significantly (p < 0.01) six months postoperatively. The G cells were still increasing in number six months after SV + P, and G cell hyperplasia became more remarkable after one year. Emiocytotic figures were observed in denervated G cells which were stimulated by meat extract or insulin hypoglycemia. On the basis of the findings of this study, it is considered necessary to conduct complete vagotomy on the parietal cell region when SV + P is performed.

Adult↗
PubMed1980

Effect of neural stimulation on acinar cell membrane potentials in isolated pancreas and salivary gland segments.

The effect of cholinergic neural excitation by field stimulation on the acinar cell membrane potential was investigated in superfused segments of mouse pancreas and salivary glands (sublingual, submaxillary, and parotid glands). Responses of acinar cells in both exocrine pancreas and salivary glands to the neural excitation obtained by field stimulation were similar to responses previously described in each gland to the externally applied acetylcholine. In the pancreatic acinar cell, electrical field simulation induced depolarization with a latency of 0.3 to 1.2 sec. This depolarization was accompanied by a marked decrease in membrane resistance. The equilibrium potential of the depolarization induced by stimulation was between - 10 and - 20 mV. In the sublingual gland, field stimulation induced depolarization of the acinar cell with a latency of 0.2 to 0.3 sec. The stimulus induced depolarization was block by the addition of atropine. In the submaxillary and parotid glands, field stimulation induced depolarization in some acinar cell and hyperpolarization in other cells. The results support evidence previously presented by Petersen and his colleagues that acetylcholine acts to increase Na+ and K+ or Na+, K+, and Cl- permeabilities in the pancreatic acinar cell and to increase K+ and Na+ permeabilities in the salivary gland [11,24].

Acetylcholine↗
PubMed1980

Effect of neural stimulation on contractile system (myoepithelial cells) in isolated salivary gland segments of rat.

The effect of cholinergic neural excitation by field stimulation on the tension of the contractile system (myoepithelial cells) was investigated in superfused segments of rat salivary glands (sublingual, submaxillary, and parotid). Electric field stimulation evoked gland tissue contraction of a few mg, which was blocked by addition of TTX or atropine. The order of the magnitude of the contraction per wet tissue weight was sublingual greater than submaxillary greater than parotid. This correlates with the order of the distribution of myoepithelial cells described in morphological investigations. Cholinergic stimulants induced contraction in all salivary glands, but adrenergic stimulants hardly evoked contraction in the sublingual gland, whereas those drugs evoked a considerable amount of contraction in the submaxillary gland. These findings seem to suggest that the contraction may originate in the myoepithelial cells. The omission of Na from the superfusing solution quickly abolished the contraction evoked by field stimulation but not the contraction induced by ACh. The omission of Ca from the solution reduced the contraction evoked not only by field stimulation but also by ACh and by high K. The results suggest that extracellular Ca is important for the initiation of myoepithelial contraction.

Acetylcholine↗
PubMed1976

Isotachophoretic analysis of peptides.

Operating conditions for the qualitative and quantitative determination of plasma kinins, human angiotensin, reduced and oxidized glutathiones and oligopeptides with the same amino acid residues by capillary-tube isotachophoresis using a potential gradient detector have been established. The potential unit (PU) value is proposed as a qualitative index for capillary-tube isotachophoresis with a potential gradient detector. As it is unaffected by changes in the operating conditions, the PU value permits inter-laboratory comparison of data. The coefficient of variation of this index under the various operating conditions used was less than 1.69%.

Amino Acid Sequence↗