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Biomedical subjects

K Kaneta

Publications and source records attributed to K Kaneta.

At least 37 records · Page 2Linked to original sources
PubMed1987

[Thyroid dysfunction following external irradiation of the neck].

Thyroid function after radiation therapy to the neck was studied in 120 patients, 110 of whom were suffered from malignant lymphomas. No patients had clinical symptoms from thyroid dysfunction, but 9 patients were given thyroid hormone after examination of thyroid function test. TSH elevation rate for 95 patients irradiated to the hole neck by dosage was 0%, 24%, 47% and 47%, for less than 30 Gy, 30-39 Gy, 40-49 Gy and 50 Gy or more, respectively. The effects of lymphangiography and systemic combination chemotherapy on the thyroid function were also discussed.

Adolescent↗
PubMed1987

[Radiation tolerance dose of the spinal cord following conventionally fractionated irradiation].

409 patients whose spinal cord were irradiated over 30 Gy with conventionally fractionated method were surveyed to study the relation between the dose of spinal cord and the incidence of radiation myelitis. Radiation myelitis was observed in 26 cases including 3 transverse myelitis ones. 5 year incidences of transverse myelitis calculated with life table method were approximately 0% at 40 Gy, 5% at 50 Gy, 10% at 60 Gy and 20% at 70 Gy. The radiation tolerance dose of the spinal cord was considered to be 50 Gy.

Adult↗
PubMed1987

[Low-grade non-Hodgkin's lymphomas--report of the Japanese Lymphoma Radiation Therapy Group (JLRTG)].

The clinical features of 102 patients with low grade non-Hodgkin's lymphomas treated from 1972 to 1981 among the hospitals belonging to the JLRTG were retrospectively reviewed. According to the Rappaport classification, there were 29 cases of NPDL, 26 of NM and 47 of DWDL. The survival rate and relapse-free survival rate for all patients at 10 years were 49% and 41%, respectively. No obvious difference in survival rate was seen by histologic type, but patients with DWDL had a better relapse-free survival rate than those with NM (P less than 0.01). This study also suggested that patients with stages I and II low grade lymphomas might be treated by irradiation alone, if they are staged properly.

Adult↗
PubMed1986

[Radiation treatment of esophageal cancer].

Carcinoma of the esophagus is difficult to be cured by irradiation because accurate extension of the tumor and presence of metastatic lymph node(s) are difficult to be visualized by diagnostic methods. Required radiation dose, effects of irradiation, 5 year survival rate and method of treatment planning are discussed here.

Aged↗
PubMed1986

[Long term results in 69 breast cancer cases treated by radiation therapy at the Radiation Department of Cancer Institute Hospital from 1947 to 1958].

Histologically proved 69 cases of breast cancer were treated by irradiation without mastectomy after either removal of primary tumor or biopsy only at the Radiation Department of Cancer Institute Hospital, Tokyo from 1947 to 1958. Five or 10 years survival rates obtained by Kaplan-Maier's method were 84.6%, 76.2% for Stage I (13 cases), 81.4%, 76.2% for Stage II (34 cases), 25%, 25% for Stage IIIa (4 cases) and 9.1%, 0% for Stage IIIb (11 cases), respectively. Our results of Stage I and II were neary the same as that of curative operation. Our stage III patients showed poorer survival rates than that of curative operation probably due to technical insufficiency.

Adult↗
PubMed1985

[Radiation treatment of metastatic breast cancer].

Breast cancer is rather radiosensitive. A total dose of 40-50 Gy (TDF about 80) is usually sufficient to control most metastatic breast cancer tumors. Radiation treatment should be applied to control tumors which are less responsive to chemo-endocrine therapy, i.e., large tumors or brain metastasis. Five-year survival rates after the start of radiation therapy to the first development of recurrence were 2/16 for local recurrence, 2/5 for supraclavicular node recurrence, 5/16 for bone recurrence and 1/4 for pulmonary recurrence, respectively. The quality of the remaining life of the patient should be the most important factor in deciding radiation treatment.

Bone Neoplasms↗
PubMed1985

[Problems and future in judgement of treatment effects].

In order to evaluate treatment method or to obtain difference among 2 or 3 different treatment methods, factors such as grouping of patient's condition, suitable effect scoring system and duration of effects are important. Relapse free survival rate is important to evaluate treatment policy towards primary disease. Rate of preservation of larynx or breast after radiation therapy will be another important point to evaluate treatment method of these diseases.

Humans↗
PubMed1984

Combined treatment of radiation and local injections of misonidazole.

The radiosensitizing effect of misonidazole is dose dependent, so theoretically it would be desirable to use as large a dose as possible. However, clinical studies have indicated a maximum tolerable dose restricting the effects of misonidazole in patients. We injected misonidazole directly into tumor tissues in combination with irradiation in an attempt to obtain a sufficiently high concentration in tumors while maintaining a low level in the blood. Concentration of the drug in tumor tissues was confirmed to be high by examination of the resected low-grade chondrosarcoma into which the drug had been locally injected prior to the operation. Blood levels were confirmed to be significantly low. Seventeen patients were treated with local injections of the drug, each with radiotherapy. All patients either had advanced tumors, or were in the terminal stage after repeated radiotherapy and chemotherapy. A relatively high radiation dose per fraction was used. Complete response was obtained in eight patients (47%) and partial response in four (24%). No change was observed in three patients (18%) while two (12%) exhibited progressive disease. In the seven patients with multiple metastatic lesions, the response of the tumors treated with this method were compared to that of the tumors treated by radiation alone in the same patient. The sensitizing effect of the drug was clearly observed in three out of seven patients. No toxicities in the nervous system or in the gastrointestinal system were observed, and no local skin damage by the injections was seen. Local injections of misonidazole were shown to have a significant radiosensitizing effect without any side effects. The combined treatment of radiation and local injections of misonidazole is considered to be a promising new treatment method.

Combined Modality Therapy↗
PubMed1984

[Application of heat pads in hyperthermia treatment of malignant skin tumors].

The application of a heat pad in the hyperthermia treatment of malignant skin tumors was examined. The temperature on the skin surface, and at a depth of 1 mm and 2 mm became 42C, 41C and 40C respectively, and was maintained for 4 hours. Two patients were treated with the heat pad alone, four were treated in combination with radiotherapy and one patient each with Pepleomycin injection and Bleomycin ointment. Irrespective of the above methods used, the heat pad was effective.

Adult↗
PubMed1983

[Lung cancer in the aged--with special reference to radiation therapy].

Frequent distributions of different histological diagnosis and stages of lung cancer patients were examined among 4 different age groups consisting of (1) older than 70 years old, (2) 69-65, (3) 64-60 and (4) younger than 60. All patients examined were male and their primary tumor had not been removed. The worst prognosis was found among the age group 69-65 years followed by the older than 70 years. Patients whose age was younger than 60 showed better prognosis. Elderly patients should be irradiated with about 10% smaller radiation field. When chemotherapy is combined with irradiation, radiation dose and field should be lower than with irradiation alone.

Adenocarcinoma↗
PubMed1983

[Radiation therapy of pulmonary metastases].

A retrospective study was performed on 140 patients with pulmonary metastases mostly from breast and head and neck cancers, to assess the efficacy of small-field irradiation. Of 140 patients, 88 patients received radiation therapy and remaining 52 patients served as control. The relative death rates of the irradiated and control groups were calculated and compared statistically in each prognostically homogeneous subgroups divided through retrospective stratification. Survival gain due to radiation therapy was recognized with a statistical significance in such patients having pulmonary metastases with diameter less than 4 cm, multiplicity less than 5 foci, and without coexistent tumor in other sites including primary site.

Adenoma↗
PubMed1983

[252Cf brachytherapy].

Value of Californium 252 brachytherapy was discussed from our experience of 117 cases treated with either mold, interstitial or intracavitary application. Differentiated adenocarcinomas, malignant melanomas or recurrent cancers occurred in anoxic scar tissues were considered to be treated more effectively by Californium 252 fast neutron than photon radiation. Optimum absorbed neutron dose was 12-18 Gy. It should be modified depending on condition of surrounding normal tissue, because normal tissue tolerance limits to fast neutron may not be the same as photon radiation.

Brachytherapy↗