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Biomedical subjects

K Kanda

Publications and source records attributed to K Kanda.

At least 199 records · Page 11Linked to original sources
PubMed1980

Mammary carcinogenic effect of low-dose fission radiation in Wistar/Furth rats and its dependency on prolactin.

The mammary carcinogenic effect in rats of low-dose fission radiation and its dependency on prolactin were studied. A total of 141 female W/Fu rats were exposed to 4.8, 8.9, or 19.5 rads of fission radiation that had both fision neutrons of 2.0 million electron volts (MeV) and gamma ray components similar to those produced by the Hiroshima bomb. Only 1 of 48 rats (2.0%) developed mammary tumor (MT) after irradiation alone, whereas 20 of 48 rats (41.6%) developed MT's if prolactin was supplied shortly after irradiation by means of grafting of the prolactin-secreting pituitary tumor. Furthermore, MT's occurred in 11 of 45 rats (24.4%) treated with prolactin as late as 12 months after irradiation, which suggested the long-term survival of radiation-induced dormant MT cells. A correlation was found between the development of MT and the elevation of serum prolactin level; most MT's appeared shortly after the grafted mammotropic pituitary tumor became palpable. The growth of MT's appeared to be promoted by prolactin in collaboration with ovarian hormones; the growth of adenocarcinomas was dependent on prolactin and ovarian hormones, whereas the growth of fibroadenomas appeared to be less hormone-dependent. Much higher biologic effectiveness, especially in the low-dose range, was found with 2.0-MeV fission neutrons compared with 14.1-MeV fast neutrons or 180-kilovolt peak X-rays in rat mammary carcinogenesis.

Adenocarcinoma↗
PubMed1980

Postpartum capillary leak syndrome. A case report.

A 29-year old healthy woman suddenly developed hypovolemic shock, anasarca, pleural effusion, and ascites in the postpartum period. Plasma leakage was thought to be caused by generalized increased capillary permeability. She was treated successfully with massive plasma transfusions, administration of norepinephrine, and early institution of respiratory support. The patient has not developed a similar episode during 1 yr of follow-up.

Adult↗
PubMed1980

[Studies on the viability of trophoblast after termination of various kinds of pregnancies (author's transl)].

Although normal value of hCG (LH level) does not necessarily indicate eradication of viable trophoblast, its confirmation has been demonstrated as a clinically useful guide for the probable prevention of choriocarcinoma after hydatidiform mole by Takeuchi et al. Choriocarcinoma preceded by other pregnancies than hydatidiform mole which has the highest risk for choriocarcinoma has drawn more attention than before in connection with the decrease of postmolar choriocarcinoma. So that I have studied the regression rate of urinary gonadotropin (hCG) after the termination of various kinds of pregnancies. In 2,433 cases of induced abortion, 695 cases of spontaneous abortion, 1,724 cases of term delivery and 43 cases of hydatidiform mole, their urinary hCG were determined to the level of physiological range of LH. The rate of hCG regression was in the order of term delivery, spontaneous abortion, induced abortion and hydatidiform mole. The younger was the gestational age of trophoblast, the slower was the regression of hCG. At one month after the termination of pregnancy, 80.1%, 11%, 0.3%, 8% and 4.1%, and at two month 55.8%, 1.6%, 0.5%, 4% and 0.5% for hydatidiform mole, induced abortion of less than 12 week of gestation, spontaneous abortion of less than 12 week of gestation, spontaneous abortion of between 13 and 20 week of gestation respectively still showed abnormal hCG value. One percent of induced abortion at 5 month, 4% of spontaneous abortion at 3 month, 0.3% of term delivery at 4 month still maintained abnormal titer. No malignant sequelae in patients under the investigation have ever been observed in the follow up period between 3 and 8 years.

Abortion, Spontaneous↗
PubMed1980

[Electrophysiologic effects of calcium channel blocking agents on the sinus node function in anesthetized dogs (author's transl)].

The electrophysiologic effects of calcium channel blocking agents, diltiazem, verapamil and nifedipine, on the sinus node function were examined in 43 anesthetized closed-chest dogs in comparison with the effects of propranolol. The parameters of sinus node function, i.e. sinus cycle length (SCL), sinus node recovery time determined by overdrive suppression (SRT), both of which are thought to reflect sinus node automaticity, and sinoatrial conduction time estimated by Strauss method (SACT), were evaluated. Intravenously administered diltiazem (0.2 mg/kg), verapamil (0.1 mg/kg) and propranolol (0.1 approximately 0.2 mg/kg) increased SCL and SRT significantly although the increase of these parameters induced by nifedipine (0.03 mg/kg) was not statistically significant. The calcium channel blocking agents did not significantly affect SACT in contrast with propranolol which showed a prolonging effect. Thus calcium channel blocking agents suppressed sinus node automaticity yet had little effect on sinoatrial conduction.

Animals↗
PubMed1980

Adjuvant endocrine therapy for operable breast cancer using the antiestrogen mepitiostane: a preliminary report.

The steroidal antiestrogen, mepitiostane (Thioderone, 2 alpha, 3 alpha-epitio-5 alpha-androstane-17 beta-yl 1-methoxycyclopentyl ether) was administered orally to 182 patients with operable breast cancer as an adjuvant therapy after mastectomy intermittently for 3 years. The mean duration of follow-up was 32 months (6 approximately 42 months). The treatment failure ratio and the time distribution of failure among those given mepitiostane were compared with those of 96 patients treated with mitomycin C. There was a recurrence of malignancy in 11.5% (21/182) of patients treated with mepitiostane and in 15.6% (15/96) of patients given mitomycin C. The recurrence rates of the postmenopausal patients treated with mepitiostane and those treated with motomycin C were 3.8% (3/80) and 17.6% (18/102), respectively. In contrast, the malignancy relapsed in 24.0% (14/39) and in 2.4% (1/42) of the premenopausal patients given mepitiostane and those given mitomycin C, respectively. Estrogen and progestrone receptors (ER, PgR) were assayed in some of the primary breast cancers. Although there was no difference in recurrence rate between the ER-positive and -negative cases, the recurrence rate of the patients with ER(+)PgR(+) tumors treated with mepitiostane was shown to be lower than those with ER(+)PgR(-) or ER(-)PgR(-) tumors. The antiestrogen mepitiostane may thus be useful in postmenopausal patients, in whom the adjuvant chemotherapy was less effective in preventing the recurrence of malignancy.

Androstanols↗
PubMed1980

Estimation of RBEs of thermal neutrons and reactor beam in the thermal neutron field for biomedical purposes.

The radiation field and reactor beam were prepared to measure the RBE of thermal neutrons and reactor beam in Kyoto University Reactor (KUR). The RBE of reactor beam with low contamination of gamma ray (1.8 x 10(11) n cm-2R-1) and high Cd ratio (5000) on HeLa cells was 1.26 at the surviving fraction of 0.90, and the estimated RBE of thermal neutrons was 5.50 at the same surviving fraction.

Cadmium↗
PubMed1979

A cause of paired ventricular extrasystoles.

Eight patients with ventricular extrasystoles are reported in whom coupling intervals of the extrasystoles to the proceding sinus beats were variable and in whom paired ventricular extrasystoles were occasionally seen. In all patients, paired ventricular extrasystoles were initiated only by comparatively late coupled ventricular extrasystoles. However, the interval between the first and the second of these paired extrasystoles was always much shorter than the coupling interval of this first extrasystole to the preceding sinus beat, so that the latter extrasystole often interrupted the T wave of the first one, indicating the R-on-T phenomenon. In two patients there was a gap between the ranges of coupling intervals for single extrasystoles and for the first ones of paired extrasystoles. These observations suggest the presence of longitudinal dissociation in the reentrant pathway as one of the causes of paired ventricular extrasystoles.

Adult↗
PubMed1978

The effects of diltiazem hydrochloride on the cardiac conduction: a clinical study of His bundle electrogram.

The effects of diltiazem hydrochloride, a new Ca++ antagonistic antianginal drug, on the cardiac conductivity were evaluted in 10 patients with atherosclerotic heart disease. His bundle electrograms were obtained by catheter technique. R-R, A-H and H-V intervals were measured before and after intravenous administration of diltiazem. Diltiazem acted towards significant prolongation in A-H interval. R-R and H-V intervals were insensitive to diltiazem. Diltiazem did not interrupt the cardiac effects of atropine when A-H prolongation was still observed in the subject pretreated with atropine. In short, diltiazem depresses the conductivity of the atrioventricular node selectively and this is not mediated through vagus tone change. This Ca++ antagonist induced A-H prolongation strongly suggests the contribution of Ca++ current on the generation of atrioventricular nodal action potential in humans.

Action Potentials↗