Platelet function and platelet-polymorphonuclear-neutrophil interaction in patients with deficient platelet lipoxygenase activity.
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Blood Platelets↗
Biomedical subjects
K Kanaji
Publications and source records attributed to K Kanaji.
[A case of Hermansky-Pudlak syndrome associated with diffuse interstitial pneumonia].
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Adult↗
[A case of chronic refractory thrombocytopenia with a remarkable response to colchicine administration].
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Adult↗
Altered arachidonate metabolism by leukocytes and platelets in myeloproliferative disorders.
The arachidonate metabolism by leukocytes and platelets was studied in 14 patients with myeloproliferative disorders including 7 patients with chronic myeloid leukemia (CML), 5 with polycythemia vera (PV) and 2 with essential thrombocythemia (ET). When the leukocytes were incubated with arachidonate and A23187, leukotriene B4 and hydroxyeicosatetraenoic acids (HETEs) were constantly detected using reversed-phase high-performance liquid chromatography in normal subjects, while selective deficiency of 5-lipoxygenase products (leukotriene B4 and 5-HETE) was found in 4 patients with CML. this novel abnormality of the leukocytes seemed to be derived from the possible deficiency of 5-lipoxygenase in these patients' polymorphonuclear neutrophils (PMNNs). The formation of 15-HETE appeared to be almost normal in all the patients. Platelet 12-lipoxygenase deficiency was detected in 2 patients with PV and 2 with CML in whom one was associated with the deficiency of 5-lipoxygenase products. These bicellular abnormalities of the arachidonate metabolism might contribute to understand dysfunctions of PMNNs and platelets in some patients with myeloproliferative disorders.
Arachidonate Lipoxygenases↗