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Biomedical subjects

K Kamijo

Publications and source records attributed to K Kamijo.

At least 109 records · Page 6Linked to original sources
PubMed1978

Specific characters of serum MAO in dogs.

The effect of Tris-hydroxymethylaminomethane (Tris) on MAO activity in dog serum was studied by a modification of the method of McEwen and Cohen. Partially purified MAO from dog serum was inhibited 75% and 31% by 10 mM and 1 nM Tris, respecitively. The inhibitory effect of Tris was 1/10 of that by nialamide and 1/1000 of that by catron. Tris also slightly inhibited MAO activity in rabbit serum, but did not affect MAO from bovine or human serum, or from dog liver, kidney or brain. The extent of inhibition of dog serum MAO by Tris remained constant during incubation for 3 hrs. The inhibition was found to be reversible and noncompetitive. Benzylamine was most rapidly oxidized by MAO of dog serum followed in order by amylamine, beta- phenylethylamine and tyramine, while tryptamine and serotonin were not oxidized. Tris inhibited MAO activity with benzylamine or butylamine as substrates, but it was scarcely inhibitory with tyramine or beta-phenylethylamine as substrate. This work shows that Tris is a specific inhibitor of dog serum MAO and suggests that dog serum MAO may differ in enzymic properties from MAO in other animals.

Animals↗
PubMed1975

[Studies on circadian rhythm and the feedback mechanism of hormone secretion from the hypothalamic-pituitary-adrenal system --pertaining to the circadian variation of feedback sensitivity in the hypothalamic-pituitary axis-- (author's transl)].

In order to investigate the relationship if any between the circadian rhythm of the hypothalamic-pituitary-adrenal system and of feedback sensitivity in the hypothalamic-pituitary axis, temporal changes of serum corticoid level and of ACTH responsiveness to metyrapone were studied in 5 controls, 4 patients with loss of consciousness due to central nervous system diseases (Group A), 2 blind subjects (Group B) and 2 patients with psychiatric disorders accompanied with sleep-wake cycle disturbance (Group C). Two patients in Group A with normal circadian rhythm of serum corticoid levels exhibited abnormal rhythm in ACTH responsiveness to metyrapone. In contrast, 2 other patients in Group A with normal rhythm in ACTH responsiveness to metyrapone exhibited abnormal circadian rhythms of serum corticoid levels. In spite of the disturbed circadian rhythm of serum corticoid levels, 2 patients in Group B showed normal rhythm in ACTH responsiveness to metyrapone. Two patients in Group C exhibited abnormalities in both circadian changes. It was concluded that there might be different control mechanisms between the circadian rhythmicity of the hypothalamic-pituitary-adrenal system and of the feedback sensitivity.

Adrenal Cortex Hormones↗