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Biomedical subjects

K Kaise

Publications and source records attributed to K Kaise.

At least 73 records · Page 4Linked to original sources
PubMed1982

Carbohydrate metabolism in thyrotoxicosis, with special reference to its relation to calorie intake.

The effects of two kinds of calorie intake, 30 kcal and 60 kcal per kg of ideal body weight with the same amount of protein, on glucose tolerance and the metabolism of thyrotoxicosis was studied. A diet of 30 kcal per kg of ideal body weight was not sufficient for the thyrotoxicosis, and all the patients lost body weight. On a diet of 60 kcal per kg of ideal body weight, weight reduction was minimal and the urinary nitrogen and blood lactate levels increased. Insulin secretion also increased on a 60 kcal diet, but there was no deterioration of glucose tolerance even in cases of thyrotoxicosis showing mild glucose intolerance. These results suggest that sufficient calories for the thyrotoxicosis are at least 60 kcal per kg of ideal body weight, irrespectively of mild glucose intolerance.

Adult↗
PubMed1981

Abnormalities of iodine and protein in the thyroid of patients with Hashimoto's thyroiditis.

Iodine content, protein content and percentage of thyroglobulin to total protein in the thyroid glands were studied in two groups of 10 patients with Hashimoto's thyroiditis (5 euthyroid and 5 hypothyroid patients) and in 6 normal subject. Iodine content was significantly decreased in both hypothyroid (24 +/- 29 microgram/g wet weight of thyroid tissue, mean +/- S.D., p less than 0.01) and euthyroid (96 +/- 52, p less than 0.01) groups of Hashimoto's thyroiditis compared with those in controls (779 +/- 37). The value of hypothyroid group was significantly smaller than that of euthyroid group (p less than 0.05). A significant negative correlation was obtained between thyroidal iodine content and serum TSH (r = -0.68, y = -0.41 chi + 55.6, p less than 0.05). Thyroidal protein and percentage of thyroglobulin to total thyroidal protein were also decreased in Hashimoto's thyroiditis compared with controls, while there was no difference between euthyroid and hypothyroid groups in these values. The percentage of thyroglobulin-bound 131I obtained by in vitro iodination of thyroglobulin in Hashimoto's thyroiditis appeared to be decreased in 2 cases of hypothyroid group. Some immunological reaction occurring in Hashimoto's thyroiditis may change the structure of thyroglobulin and in turn the normal iodination of thyroglobulin may be disturbed.

Adult↗
PubMed1980

Long-term results of radioiodine (131I) therapy in 331 patients with Graves' disease.

To evaluate the long-term results of 131I treatment for Graves' disease, the thyroid function was studied in 331 patients 5-17 years after this therapy. Twenty-five patients were hypothyroid and had already been on thyroid medication. Among the remaining 306 patients without any treatment for thyroid disorder, 188 patients (61.4%) had a normal thyroid-stimulating hormone (TSH) level (less than 10 microU/ml) of whom 151 were euthyroid with normal thyroxine (T4) and triiodothyronine (T3) level. 118 patients (38.6%) had a high TSH level, of whom 22 were hypothyroid with low T4 and T3 levels and 38 with normal T3 and low T4 levels, and 14 patients out of this 38 were clinically hypothyroid. Although all of the patients with high TSH levels do not per se require the replacement therapy for hypothyroidism, the overt hypothyroidism seems to occur sooner or later in patients with a lower T4 level. Among 331 patients studied, 61 (18.4%) were clinically hypothyroid. The incidence of hypothyroidism was 20.7% after 10 years of 131I treatment and 33% after 15-17 years. The incidence of patients with high TSH levels was 50% after 10 years of 131I treatment and 60% after 15-17 years. Both of cumulative incidence of hypothyroidism and patients with high TSH levels increased linearly with years after the treatment, which coincided with the linear decrease of mean T4 and T3 levels and linear increase of mean TSH level with years after the treatment. The difference of positive incidence of antithyroid antibodies between cases of normal TSH level and high TSH level was not significant.

Autoantibodies↗
PubMed1980

Gluconeogenesis from glycerol and alanine in thyrotoxicosis.

Gluconeogenesis in thyrotoxicosis was studied by oral glycerol-loading test and alanine-loading test performed on 5 normal subjects and 5 cases of thyrotoxicosis. The blood glucose levels in thyrotoxicosis rose after the administration of glycerol deposit elevation of the plasma levels of insulin. After the administration of alanine, the levels of IRI, pyruvate and lactate elevated in thyrotoxicosis. In normal subjects, the plasma levels of glucose, IRI, pyruvate, or lactate did not change significantly after glycerol or alanine load.

Administration, Oral↗
PubMed1980

A solid-phase radioimmunoassay for free thyroxine in serum compared with equilibrium dialysis method.

Serum free thyroxine (T4) was measured by a solid-phase radioimmunoassay in various thyroid states and in those associated with changes in serum T4-binding proteins. And it was compared with the value obtained by product of total serum T4 and of per cent free T4 by equilibrium dialysis. Serum free T4 concentrations were found to be 1.34 +/- 0.33 ng/100 ml (mean +/- S.D.) in 51 normal subjects, 5.02 +/- 1.41 ng/100 ml in 29 hyperthyroid patients, 0.16 +/- 0.15 ng/100 ml in 12 hypothyroid patients, and the value in each individual of the latter two groups was significantly different from normal. Serum free T4 was normal of 1.23 +/- 0.22 ng/100 ml in 7 pregnant women and all had free T4 levels within the normal range. Moreover, five out of six patients with decreased thyroxine-binding globulin had normal free T4 levels, though their mean value (0.85 +/- 0.20 ng/100 ml) was significantly lower than the normal value. An excellent correlation (r = 0.93) was observed between values for serum free T4 obtained by the present method and those by the equilibrium dialysis method. The simplicity, accuracy, sensitivity, and specificity of this assay render it highly attractive for routine clinical determination.

Dialysis↗
PubMed1980

Measurement of triiodothyronine in urine.

A radioimmunoassay procedure to measure triiodothyronine (T3) in unextracted urine is described. One hundred microliter of T3 standards or samples were incubated with 100 microliter of T3 antiserum (1:40,000), 100 microliter of tracer 125I-T3 and 700 microliter of 0.05 M borate buffer, pH 8.6. Separation of free from bound antigen was achieved by dextran coated charcoal. The cross-reaction of L-T3 with L-T4 in this assay system was less than 0.2%. Dilution of high T3 urine was parallel to the standard curve. Recovery was 101 +/- 8%. Coefficients of variation were 3-8% within each assay and 13% between assays. Euthyroid subjects excreted 0.81 +/- 0.39 microgram (mean +/- S.D.) in 24 hr. Similar values were obtained in pregnant women, euthyroid patients with chronic thyroiditis, and a patient with thyroxine-binding globulin deficiency. Excretion of urinary T3 was high (7.48 +/- 3.32 microgram/24 h) in patients with hyperthyroidism, and low (0.14 +/- 0.15 microgram/24 hr) in patients with hypothyroidism. Urinary T3 excretion was almost undetectable in terminal renal failure. Positive correlations were found between urinary T3 and serum total T3 (r = 0.89) and especially serum free T3 (r - 0.97). A positive correlation was also found between urinary T3 and creatinine clearance (r = 0.63). Mean urinary clearance of T3(CT3=Urinary T3 excretion/serum free T3 was 166 ml/min and was significantly higher than their mean creatinine clearance (110 ml/min). The measurement of T3 in urine is reliable and easy to perform, and may allow a new approach to the understanding of thyroid hormone metabolism.

Female↗