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Biomedical subjects

K Kadota

Publications and source records attributed to K Kadota.

At least 235 records · Page 13Linked to original sources
PubMed1978

[Neurofilament hypertrophy induced in the rabbit spinal cord after intracisternal injection of aluminum chloride (author's transl)].

The cytological changes induced in the spinal cords of rabbits by intracisternal injections of aluminum chloride have been studied at the light- and electron-microscopic level for examining the progress of the 100 A filament hypertrophy. A moderate increase in the number of the 100 A filament was detected in perikarya of neurones in anterior, lateral, and dorsal horns 4--5 days after aluminum injection. Tangles of 100 A filament were seen in perikarya and proximal parts of dendrites in these neurones 1--2 weeks after the administration of aluminum. In this stage the tangles were detected as large clear spots at light-microscopic level. The 100 A filament bundles developed in between clumps of densely aggregated endoplasmic reticulum keeping close contact with this and squeezing other organella out. In high resolution studies the 100 A filament closely resembled the neurofilament in normal neurones in size and appearances and was seen to be connected with each other via side arms coming out from its wall. Relations between the endoplasmic reticulum and the 100 A filament hypertrophy was discussed referring to intoxicating effects of aluminum compounds on the nucleus of the neuron.

Aluminum↗
PubMed1976

Coated-vesicle shells, particle/chain material, and tubulin in brain synaptosomes. An electron microscope and biochemical study.

Coated vesicles (CVs), plain synaptic vesicles (PSVs), and nonvesicular flocculent material were isolated from synaptosomes and examined with goniometry and high-resolution electron microscopy after either negative staining or various biochemical procedures. The flocculent material (i.e. the presynaptic matrix material except CV shells) is largely composed of particulate or elongated (chainlike) structures; some of this material (here referred to as particle/chain material) is attached to PSVs. The results obtained were: (a) the proteinaceous properties of the CV coat (also referred to as CV shell) and the particle/chain material were demonstrated with chymotrypsin; (b) the CV shell, studied with various negative-staining techniques, differs from the particle/chain material since it has no 3-4-nm globular subunits and reacts differently to alkaline pH; (c) the particle/chain material consists of aggregates of 3-4-nm globular subunits, four of which yield 8-10-nm fine particles; and these particles can be further aggregated into chains 8-10 nm wide and up to 30-60 nm long showing a "hollow" core; (d) vinblastine sulfate induced ringlike or helical crystalloid precipitates closely resembling the vinblastine-induced microtubule crystals reported in the literature, but vinblastine had no effect on either the CV shell material or the particle/chain material.

Animals↗
PubMed1975

[A case of arteriovenous communication between external and internal carotid arteries and the sinus after removal of the meningioma (author's transl)].

A 60-year-old man was admitted with anosmia, memory disturbance and disorientation in 1971. He was diagnosed the left olfactory groove meningioma and received the removal of the tumor after ligation of the left external carotid artery. Over the following two years he was admitted again with progressive memory disturbance and mental disorder in Aug. '73. Physical examination disclosed no abnormalities except for slight hypertention. His CSF pressure was 120 mm H2O and pneumoencephalograms showed marked dilatation of the lateral ventricles. Right carotid angiography revealed the right olfactory groove meningioma which was receiving a rich circulation from the branches of right ophthalmic artery. And right selective external arteriography showed an arteriovenous communication between the occipital artery and the transverse sinus. Contrast medium flowed to the left transverse sinus. Left internal carotid arteriography showed an anomalous arteriovenous communication between the tentorial branch (Bernasconi-Cassinari artery) of the internal carotid artery and sigmoid sinus. Further left vertebral arteriography revealed another arteriovenous communication between the left occipital artery anastomosed with vertebral artery and the transverse sinus. An operation for the right olfactory groove meningioma was made in Sep. '73. Some considerations on the pathogenesis of developement of these arteriovenous communications were discussed.

Arteriovenous Fistula↗
PubMed1975

[A clinical survey of brain abscess (3rd report): special reference to chronological analysis of EEG on brain abscess (author's transl)].

The attention of those concerned with the management of intracranial abscess has been largely directed to a study of the findings in clinicopathological and neuroradiological investigations. Our object, in this communication is to arouse interest in the electroencephalographic survey, especially chronological electroencephalographic study of absecess patients. The clinical material forming the basis of this study is drawn from a series of 46 consecutive cases of intracranial abscess treated, during 3 years, in the neurosurgical department of Tokyo Women's Medical College.

Adolescent↗