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Biomedical subjects

K K Verma

Publications and source records attributed to K K Verma.

At least 37 records · Page 2Linked to original sources
PubMed1994

Subcutaneous mucormycosis in a non-immunocompromised patient treated with potassium iodide.

A 55-year-old teacher had had painful subcutaneous swellings on both her arms for 6 years, after receiving intramuscular multivitamin injections for generalized weakness. She did not have fever, constitutional or systemic symptoms. Cutaneous examination revealed ill-defined, subcutaneous, firm, globular, indurated, tender swellings with central softening on both the arms. There was no systemic involvement or lymphadenopathy. Aspiration cytology from one of the lesions showed inflammatory exudate with a mucor-like fungus. Skin biopsy revealed granulomatous inflammation with fungal hyphae resembling mucor within the giant cells. The patient was diagnosed as subcutaneous mycormycosis and treated with saturated solution of potassium iodide. Both the lesions completely disappeared within 10 weeks without any side-effect of the therapy.

Female↗
PubMed1994

Methotrexate in psoriatic arthritis.

Thirty three patients with psoriatic arthritis were treated with starting dose of 7.5 mg of methotrexate orally, every week for a period of 6 months to 7 years (mean 2.2 years) along with non-steroidal anti-inflammatory agents. The dose of methotrexate during the course of therapy ranged 5 to 15 mg/week (mean 7.8 mg). There was complete to partial remission in arthritis and psoriatic skin lesions in 94% (31) patients. No response was noticed in 2 patients. Regular monitoring of haematological, renal and liver function tests was done. No significant side effects of the drug, requiring discontinuation of the therapy, were seen during the treatment. Methotrexate can be used early in the course of psoriatic arthritis with good results.

Administration, Oral↗
PubMed1993

Antibody deposits in Tzanck smears in pemphigus vulgaris.

Forty-three patients, including 24 males and 19 females between 5 and 62 years of age, having pemphigus vulgaris (27), pemphigus foliaceus (1), bullous pemphigoid (3), chronic benign bullous dermatosis of childhood (2) and herpes zoster (10) were included in this study. Tzanck smears were prepared from the floor of the blisters in these patients by deroofing the bullae, and the slides were stored without fixation at room temperature for 1 to 10 days. Immunofluorescence staining was done with FITC-conjugated anti-human IgG. Twenty-one cases having pemphigus vulgaris and 1 case having pemphigus foliaceus showed bright green fluorescence on the membrane of acantholytic cells. No epithelial cells were seen in smears from bullous pemphigoid and chronic benign bullous dermatosis of childhood, whereas epithelial cells were seen in 10 cases of herpes zoster. These stained negative with anti-IgG. Storage of the prepared smears for 1-10 days did not seem to affect the results of immunofluorescence. Tzanck smears can be used as an easy substitute for skin/mucosal biopsy for the direct immunofluorescence test.

Adolescent↗
PubMed1992

Dapsone in cutaneous lesions of SLE: an open study.

This short report describes a possible beneficial effect of dapsone in the treatment of chronic unresponsive muco-cutaneous lesions of systemic lupus erythematosus (SLE) without any serious side effects.

Adult↗
PubMed1991

Is the Narmada hominid an Indian Homo erectus?

In 1982 a fossil hominid calvaria was found in a middle Pleistocene deposit in the central Narmada valley of Madhya Pradesh, India, and was assigned to the new taxon Homo erectus narmadensis. Subsequently, morphometric studies of the specimen were conducted by two separate research teams from France and the United States, both in collaboration with Indian colleagues. Results of the most recent study, which includes morphometric and comparative investigations, lead to the conclusion that "Narmada Man" is appropriately identified as Homo sapiens. While the calvaria shares some anatomical features with Asian Homo erectus specimens, it exhibits a broader suite of morphological and mensural characteristics suggesting affinities with early Homo sapiens fossils from Asia, Europe, and Africa as well as demonstrating that the Narmada calvaria possesses some unique anatomical features, perhaps because the specimen reflects the incoherent classificatory condition of the genus Homo.

Age Determination by Skeleton↗
PubMed1991

Spectrophotometric determination of ascorbic acid in pharmaceuticals by background correction and flow injection.

Background correction has been shown to be an effective and indispensable modification in the spectrophotometric determination of ascorbic acid. The decomposition of ascorbic acid in pharmaceutical samples was carried out by incubation with sodium hydroxide to give products that were insensitive to ultraviolet light. The rapid oxidation in air of ascorbic acid, especially in dilute solutions, was avoided by the use of the flow injection principle for spectrophotometric determination and by employing a carrier stream of an anti-oxidizing nature consisting of 6 micrograms ml(-1) of 2-mercaptoethanol in 0.25% sulphuric acid. The optimized method with a single channel manifold made use of a carrier stream flow rate of 1.1 ml min(-1), an injection volume of 50 microl, a delay coil of 50 cm (0.5 mm i.d.) and detection at 245 nm. The throughput was at least 180 injections h(-1). The proposed flow injection method yielded results for the analysis of 0-20 micrograms ml(-1) of ascorbic acid that were 99-102% (relative standard deviation 0.6% or better) in agreement with those produced by comparable methods involving titration with iodine, chloranil or 2,6-dichlorophenolindophenol [4-(2,6-dichloro-4-hydroxyphenylimino)cyclohexa-2,5-dieno ne], and high-performance liquid chromatography. When the agreement was not good (as low as 14% with respect to the method being compared), this was traced to the presence of substances which are known to interfere in one or other of the methods of comparison.

Ascorbic Acid↗
PubMed1990

Determination of amodiaquine in pharmaceuticals by reaction with periodate and spectrophotometry or by high-performance liquid chromatography.

Two methods are described for the determination of amodiaquine in pharmaceuticals. In the first method, amodiaquine was treated with periodate at pH 7.5-8.5 to yield a chromogen, which is believed to be a 1,4-benzoquinone imine derivative, and extracted into chloroform for spectrophotometric assay. The maximum molar absorptivity was found to be 2.17 x 10(3) l mol-1 cm-1 at 442 nm. Primaquine and chloroquine, if present also, do not interfere. The second method, which was used for the simultaneous determination of amodiaquine, primaquine and chloroquine, is based on high-performance liquid chromatography on an octadecylsilane column using a mobile phase of methanol-water (80 + 20) containing 0.5% anhydrous acetic acid and an over-all concentration of sodium dodecyl sulphate of 0.5 mM, with detection at 340 nm.

Amodiaquine↗
PubMed1987

Determination of aspirin by pre-column transacetylation reaction of 3-aminophenol and reversed-phase high-performance liquid chromatography: simultaneous determination of aspirin, acetaminophen, and caffeine.

The accuracy of the measurement of aspirin by high-performance liquid chromatography (HPLC) is reduced by its hydrolysis into salicylic and acetic acids during sample preparation. The ready and quantitative transacetylation of 3-aminophenol by aspirin, giving 3-hydroxyacetanilide (which is stable), has been utilized as a pre-column reaction for the determination of aspirin either alone or in the presence of acetaminophen and caffeine by reversed-phase HPLC.

Acetaminophen↗