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Biomedical subjects

K K Sharma

Publications and source records attributed to K K Sharma.

At least 127 records · Page 7Linked to original sources
PubMed1983

Possible interrelationship between the biogenic amines involved in the modulation of footshock aggression in rats.

Dopamine, 5-hydroxytryptamine and 4-methylhistamine facilitated whereas noradrenaline and 2-pyridylethylamine inhibited footshock aggression (FSA) in rats. Dopamine increased FSA in cyproheptadine and cimetidine but not in pimozide pretreated animals; 5-hydroxytryptamine potentiated FSA in cimetidine and pimozide but not in cyproheptadine pretreated rats; 4-methylhistamine facilitated FSA in pimozide and cyproheptadine but not in cimetidine pretreated groups. Also 2-pyridylethylamine inhibited FSA in phenoxybenzamine but not mepyramine pretreated animals. These effects were not significantly different from those seen with dopamine, 5-hydroxytryptamine, 4-methylhistamine and 2-pyridylethylamine, alone, respectively on FSA. It is inferred that each of the neurotransmitters involved in the modulation of footshock aggression acts through an independent mechanism which is not under the regulatory control of the other.

Aggression↗
PubMed1981

Effect of histaminergic drugs on footshock-induced aggressive behaviour in rats.

Histamine and 2-pyridylethylamine decreased and 4-methylhistamine increased footshock-induced aggression after their intracerebroventricular administration to rats. Mepyramine and cimetidine had no effect on the fighting response but blocked the effects of the respective agonists. Histamine when given after mepyramine increased and after cimetidine decreased the fighting score, this decrease being more than that with histamine alone. It is inferred that central H1-receptors are inhibitory and H2-receptors facilitatory in footshock aggression and that this is independent of catecholaminergic mechanisms.

Aggression↗
PubMed1981

Effects of antibacterial agents on the complement system.

The alteration of serum complement profile following therapy with various antibiotics was studied in 23 hospitalized patients and in 10 human volunteers. Tetracycline, chloromycetin, ampicillin, and streptomycin reduced serum CH50 and C3 levels in the inpatients. Tetracycline administration for three consecutive days in four normal subjects decreased serum CH50, C1q, C3, and C4 levels on day 4. However, these parameters returned to near-normal levels on day 7 following the withdrawal of the drugs. On the other hand, septran administered in six normal individuals for three consecutive days had no significant effect on the complement system. In vitro studies as well as in vitro studies in guinea pigs treated with various antibiotics showed almost parallel results.

Animals↗