Biomedical subjects

K K Misra

Publications and source records attributed to K K Misra.

12 recordsLinked to original sources

PubMed2001

Histopathology of Trypanosoma (Trypanozoon) evansi infection in bandicoot rat. I. visceral organs.

Experimental infection of Trypanosoma (Trypanozoon) evansi in Bandicota bengalensis produces an acute disease course leading to untimely death of the bandicoot rat. The sequential alteration of liver, spleen, lung, kidney, and heart was studied on the 5th, 8th, 12th, and 14th days postinoculation. The rats showed inflammatory, degenerative, and necrotic changes in these organs. In liver, pseudolobule formation, necrosis and hemorrhage within the sinusoids, and fatty degeneration of hepatic cells were the predominant histopathological changes. The changes were destructive and irreversible. In spleen giant cells aggregation and granulomatous lesion, i.e., accumulation of histiocytes, were the protective changes, whereas tissue and cell damage indicated irreversible degeneration. The gradual development of intrabronchus inflammation, aggregation of inflammatory cells around the alveoli, congestion of bronchioles, septal edema, atrophy of alveolar walls, migration of macrophages, and emphysema were the histopathological changes noticed in the lungs of the infected rats. The affected kidney showed infiltration of lymphocytes, hemorrhage in the interlobular space, and glomerulitis as the irreversible and destructive changes in the rats. There was degeneration of myocardium in the hearts of the rats. The histopathological changes in these organs are compared with those studied in surra, human sleeping sickness disease, and African trypanosomiasis. Possible mechanisms for these histological changes in the visceral organs are discussed.

Animals↗

PubMed1987

Nursing the immobile: a preliminary study.

Permanent loss of mobility has profound physical and mental consequences for both sufferers and carers, and is a major challenge to the National Health Service. A recent study has shown that 42% of beds in departments of Geriatric Medicine are occupied by people with longstanding immobility. These people are highly dependent on nursing staff for their daily activities and quality of life. The assessment of mobility, as a single parameter of dependency, and the measurement of allocated nursing hours are both rapidly and easily performed on geriatric wards. It is felt that a simple correlation of these two variables might highlight areas where more detailed audit is desirable. This study demonstrates that the more immobile patients on a ward, the less the hours allocated to Registered and Learner grade nurses. Some possible reasons for this are suggested and the effects of this deployment on nursing practice and staff recruitment are discussed. It is felt that provision of appropriate nursing care to the most dependent patients in continuing care areas is essential, and that high levels of trained staff are needed to ensure this.

Activities of Daily Living↗

PubMed1987

The bedfast.

Many geriatric beds are occupied by bedfast patients. Most were immobile from the time of admission and many were admitted from other hospital departments or residential care. More are discharged home than remain in hospital or are transferred to any other institution. Although a small minority of admissions become long-term bedfast inpatients this group require a disproportionate resource commitment. Reduction in the number of bedfast inpatients is more likely to be effected by changes in unit policy than by improvement in clinical practice.

Aged↗

PubMed1985

Determinants of work capability and employment after coronary artery surgery.

In 120 patients subjected to coronary artery surgery we have investigated employment status and work capability in relation to age, pre-operative ventricular function and extent of coronary artery disease, peri-operative infarction and post-operative angina. The patients were followed up for 6 to 23 months (mean 10 months). Fifty-three out of 74 patients (72%) employed before the onset of angina, returned to work after operation. Return to work was more likely in patients working immediately prior to surgery and in patients less than 45 years old (P less than 0.05). Sixty patients (50%) reported a return to normal work capability, the most striking changes occurring in those less than 45 years old (P less than 0.02). Pre-operative left ventricular (LV) function and extent of coronary disease and mode of employment did not correlate with post-operative employment status but normal LV function was related to improvement in work capability (P less than 0.02). Return to work after coronary bypass surgery is mainly due to angina relief but is also related to age and pre-operative work status.

Adult↗

PubMed1979