Biomedical subjects

K K Lie

Publications and source records attributed to K K Lie.

At least 19 recordsLinked to original sources

PubMed1999

[Drug prescription to 4-year-old children in the county of Vestfold].

We carried out a study of four-year-old children's general health, diseases and use of medicines over a 12-month period in 1995-96. The study was based on a questionnaire administered in connection with the regular health controls. Questionnaires from 1,912 children were returned, representing 79% of children born during one year in the county. More than half the children had received medicine prescribed by a physician, corresponding to 557 preparations per 1,000 children. Some children had used several types of drugs, with a mean of 1.4 preparations per child. Antibiotics were prescribed to 63% of the children. Compared to what has been found in other studies, the use of prescribed medicine was moderate. More pharmacoepidemiological studies are needed to assess whether the use of medicine in children is at an acceptable level.

Anti-Asthmatic Agents↗

PubMed1997

[Children and health--health visitors' challenges in a multicultural society].

Explore the source record for details and available documents.

Adult↗

PubMed1997

[Health status survey in a district with many immigrant children].

In Norway, prophylactic child health care is organized through local mother and child clinics, each of which serves a given population. This study summarizes the findings from the routine check-up of four-year-olds in a district with a high proportion of immigrant families. The sample consisted of 70 children, 33 of them from immigrant families. The ordinary check-up was supplemented by information obtained by means of a questionnaire, which was filled in by the public health nurse and the doctor in consultation with the parents. A validated scale, or checklist (BCL), for ordinary behavioural problems among pre-school children was also included. The findings must be interpreted with caution, one reason being the large socio-economic differences between the immigrant and the Norwegian families included in the study. Nevertheless, the difference between the eating habits of the two groups of children was striking, in spite of the emphasis placed on diet at the clinic. Another important finding was the poor knowledge of Norwegian among the immigrant children, which was obviously associated with the poor language skills of the mothers. Therefore, an important element of the preventive health work among immigrant children should be to encourage the mothers to attend courses in Norwegian.

Child Health Services↗

PubMed1994

[Infection problems connected to child day care centers].

International studies show that children in day care centres have approximately twice as many episodes of infectious diseases as children cared for at home, while, according to most studies, children in family day care experience an intermediate number of infections. After some months in day care the risk of infection decreases. The diseases in question are usually transferred from person to person through close physical contact. Children's general mode of behaviour tends to favour such transmission. The risk of infection in pregnant women on the day care staff and among parents is considered. Finally, the author discusses the potential to control infection in a day care setting. Strict rules for isolation of sick children probably have little effect on the spread of the infections. Good routines for washing hands and for changing nappies are considered to be the most important ways of controlling infection in day care centres.

Bacterial Infections↗

PubMed1979

Clinical and pharmacologic studies with adriamycin-DNA complex in children with malignant disease.

During the last 4 years, we have studied the adriamycin-DNA complex originally developed by Trouet and co-workers (1972). This paper summarizes the results of our pharmacologic and clinical studies. The complex is taken up by cells through an adsorptive pinocytosis, with DNA as the binding molecule. Excess DNA prevents uptake of the drug. Administration of the drug as the complex results in much higher serum concentration and a reduced urinary excretion. The complex is well tolerated, but side effects are probably of the same order as those seen with the free drug. An exception may be the heart. The acute toxicity is not seen when infusing the complex. Our experience with 20 children who have received more than 500 mg/m2 indicates that the chronic cardiac toxicity may be reduced, too. Spectacular, but anecdotal, results have been observed in a variety of solid tumors. Of 16 children with acute myelogenous leukemia, 14 went into a complete remission on a protocol of cytosine arabinoside in combination with the complex. Three of these children are now off therapy, with the longest observation period being 4 years and 4 months.

Child↗

PubMed1978

A pharmacokinetic evaluation of free and DNA-complexed adriamycin: a preliminary study in children with malignant disease.

The pharmacokinetics of adriamycin given as free and in DNA-complexed form was compared in six children with malignant disease. The two types of adriamycin were given to the same child at 3--4-week intervals, thereby excluding genetic variations when comparing the results. Plasma and urine were collected during and after the drug infusion, and the drug concentrations were measured by means of a sensitive fluorimetric procedure. The study shows that one obtains: 1. a much higher plasma concentration of adriamycin when it is given in the complexed form. 2. a lower urine excretion of adriamycin and fluorescent metabolites when adriamycin is administered as the DNA-complex.

Child↗

PubMed1975