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Biomedical subjects

K K Jain

Publications and source records attributed to K K Jain.

At least 19 recordsLinked to original sources
PubMed1986

Incision of the brain with the Varipulse carbon dioxide laser: a preliminary study for potential application in neurosurgery.

Incisions were made into the rat brain using the Varipulse carbon dioxide laser; they were compared with those made by using an equal amount of energy in the continuous mode of the same laser. Histological examination of the cross sections of the incisions was done. The Varipulse CO2 laser, in comparison with the continuous wave CO2 laser, caused less damage to the tissues surrounding the incision. A 500 Z (peak power, 500 watts) NIIC carbon dioxide laser (Cooper Laser Sonics, Santa Clara, California) equipped with a microcomputer was used with a pulse repetition rate of 200 to 400 and a pulse width of 0.1 second. A focused spot of 0.2 mm and a constant speed of incision of 5 mm/second was used for both types of lesions. The potential usefulness of the Varipulse CO2 laser in neurosurgery, as well as the precautions to be observed during its use, are discussed.

Animals↗
PubMed1985

A prospective randomized comparison of epirubicin and doxorubicin in patients with advanced breast cancer.

Fifty-four patients with advanced breast cancer who had failed prior non-anthracycline combination chemotherapy were randomized to treatment with either epirubicin 85 mg/m2 or doxorubicin 60 mg/m2 intravenously every three weeks. Of 52 evaluable patients, 25% (six of 24) treated with epirubicin, and 25% (seven of 28) treated with doxorubicin experienced major therapeutic responses. The median duration of response to epirubicin was 11.9 months compared to 7.1 months with doxorubicin. Cardiotoxicity was monitored by serial multigated radionuclide cineangiocardiography performed at rest and after exercise. Laboratory evidence of cardiotoxicity was defined as a decrease in resting left ventricular ejection fraction of greater than 10% from the baseline value, or a decrease of 5% or greater with exercise compared with the resting study performed on the same day. Fifteen patients treated with epirubicin and 18 patients treated with doxorubicin had at least two determinations of left ventricular ejection fraction and were evaluable for laboratory cardiotoxicity. Using methods of survival analysis, the median doses to the development of laboratory cardiotoxicity were estimated to be 935 mg/m2 of epirubicin and 468 mg/m2 of doxorubicin. Four patients treated with epirubicin and five treated with doxorubicin developed symptomatic congestive heart failure. The median cumulative dose at which congestive heart failure occurred was 1,134 mg/m2 of epirubicin compared with 492 mg/m2 of doxorubicin. Fewer episodes of nausea and vomiting were observed in patients receiving epirubicin. Epirubicin is a new anthracycline with reduced cardiac toxicity, but preserved efficacy in the treatment of patients with advanced breast cancer.

Actuarial Analysis↗
PubMed1985

Complications of use of the neodymium: yttrium-aluminum-garnet laser in neurosurgery.

Review of the clinical records of 32 patients who underwent operation for brain tumors with the use of the neodymium:yttrium-aluminum-garnet (Nd:YAG) laser during a 4-month period revealed 5 cases of complications related to laser use. One death was presumed to be due to intratumor explosion (the popcorn effect) after excessive Nd:YAG laser application. The other death was due to heat necrosis of the brain stem after radiation of an ependymoma of the 4th ventricle. Two patients suffered neurological deficits. One had facial palsy after radiation of the site of attachment of a meningioma to the petrous bone. The other suffered aphasia and hemiparesis due to heat damage to the cerebral cortex after laser coagulation of the overlying dura mater. The fifth patient suffered postoperative hemorrhage in a residual necrotic chromophobe adenoma after a transsphenoidal approach using the Nd:YAG laser. These complications are preventable. Suggestions are made for the safe use of this laser.

Adenoma, Chromophobe↗
PubMed1984

The treatment of extragonadal seminoma.

Primary extragonadal seminoma (EGS) is a rare tumor of young adults that often presents with bulky primary tumors and metastatic disease. Long-term survival is inadequate with conventional therapy consisting of radiotherapy with or without surgery. The charts of 21 patients with EGS treated initially either with conventional therapy (group I) or with multimodality therapy including initial chemotherapy with high doses of cisplatin followed by either radiotherapy or surgery or both (group II) were reviewed. Five of the ten patients in group I developed recurrent disease and four of them eventually died of disease. Only one of 11 patients in group II died of metastatic disease and the remaining patients are free of disease with 19+ to 46+ months of follow-up. Of the six patients from group II who underwent surgical resection of apparently residual disease after chemotherapy but prior to radiotherapy, five were found to have completely necrotic tumor and one had microscopic disease on histologic examination, proving the efficacy of chemotherapy. Combined modality therapy including initial chemotherapy containing high doses of cisplatin provided rapid reduction in tumor burden and the results appeared superior to treatment that did not include initial chemotherapy.

Adult↗
PubMed1979

Asymmetry in the skull.

Various linear and angular measurements were taken in 118 normal skulls of adult humans. The two halves of the skulls were found to be symmetrical. The phenomenon of asymmetry of various parts of the body, in relation to cerebral dominance and specific skills has been discussed in view of the findings of the study and in the light of the available literature.

Adult↗
PubMed1979

Repair of small blood vessels with the neodymium-YAG laser: a preliminary report.

A technique for repair of incisions in small blood vessels (diameter, 0.3 to 1.0 mm) in the rat is described using a Neodymium-YAG laser. It is possible to seal the incision without the use of sutures and to preserve the lumen of the vessel. The advantages of this technique over electrocoagulation and microsuture techniques are pointed out. Although the work is in preliminary stages, the technique is considered to be relatively safe, and the potential use of the application in human surgery is indicated. The possible complications of this technique are pointed out.

Animals↗
PubMed1976

Anatomical observations of the subarachnoid cisterns of the brain during surgery.

Subarachnoid cisterns and their contents are described briefly in the light of observations made during microsurgical explorations. The concept of intracranial surgery in terms of moving from one cistern to another is presented here with particular emphasis on the cisterns in surgical approaches to intracranial vessels and nerves for the treatment of aneurysms, arteriovenous malformations, and for surgery of basal tumors.

Brain↗
PubMed1976

Arteriovenous malformations of the anterior and the middle portions of the corpus callosum: microsurgical treatment.

The arterio-venous malformations of the corpus callosum are distinct clinical and surgical entities. Review of literature reveals 45 documented cases of which 32 were treated surgically. The authors (M.G.Y.) had 18 such patients of which eight involved the anterior and the middle portions of the corpus callosum. (No. 8 involved the whole callosum). The patients were in the younger age group. Headache and stiffness of the neck were the common presenting features. Seizures were rare and there was a paucity of localizing neurological signs. These AVMs are supplied mainly by the pericallosal arteries and occasionally by branches of the posterior cerebral artery. The drainage is by septal veins, the inferior sagittal sinus and the superior sagittal sinus. Radical excision of these AVMs in the anterior and the middle portions of the corpus callosum was accomplished without operative mortality and with minimal morbidity. Radical removal of these anomalies with microsurgical techniques is the treatment of choice.

Adolescent↗
PubMed1976

Arteriovenous malformations of the splenium of the corpus callosum: microsurgical treatment.

Ten patients with arteriovenous malformations (AVM) involving the splenium of the corpus callosum are presented. All were treated by microsurgical techniques with no mortality and minimal morbidity. The diagnosis and operative technique is described, and these AVMs are compared with those involving the anterior and the middle portions of the corpus callosum.

Adolescent↗