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Biomedical subjects

K Juel

Publications and source records attributed to K Juel.

64 records · Page 4Linked to original sources
PubMed1985

Mortality and cancer morbidity after heavy occupational fluoride exposure.

A cohort of 431 male cryolite workers employed for at least six months between 1924 and 1961 was identified from personnel records at the Copenhagen cryolite factory. During this period, heavy fluoride exposure resulted in at least 74 cases of skeletal fluorosis. All workmen in the cohort were followed up in Denmark until July 1, 1981. During 1941-1981, 206 men died, while only 149.3 deaths were expected from national mortality statistics. Significant excesses were seen in the following causes of death: violent death and all cancers, in particular cancer of the respiratory system. When compared with specific mortality rates for the Copenhagen area, violent death (and suicide taken alone) remained in significant excess among employees hired before 1940. Cancer morbidity data for the 35-year period 1943-1977 showed 78 cases of malignant neoplasms in the cryolite workers against 53.2 expected for Denmark as a whole and 67.9 for Copenhagen. The excess was almost entirely due to an excess number of respiratory cancers. Cancer morbidity showed no apparent correlation with length of employment or time from first exposure. Because detailed information on predictors for respiratory cancer was unavailable, a possible residual effect of fluoride cannot be excluded. However, any major carcinogenic effect of heavy fluoride exposure would be very unlikely.

Denmark↗
PubMed1985

Myocardial infarction and cerebral infarction in a Danish suburban community.

A comparison was made of 485 cases of cerebral infarction (CI), registered prospectively in Frederiksberg, Copenhagen, with 495 cases of myocardial infarction (AMI), recorded retrospectively in the same population. The overall annual incidence of AMI was 6.5 per 1,000 population for males, 3.8 for females; the rates for CI were 2.4 and 2.5, respectively. The age-incidence curves, particularly those for AMI, were significantly steeper in the females than in the males. Correspondingly, the male predominance in the AMI-group subsided with age. Age-specific incidence-rates rose exponentially with advancing age; for each sex and diagnosis the relationship can thus be expressed as a simple mathematical formula, which may facilitate comparisons of incidence patterns in different communities. Theories explaining the similarities and differences of the age-incidence curves for AMI and CI are discussed.

Adult↗
PubMed1983

Demographic factors and cancer mortality. A mathematical model for cancer mortality in Denmark 1943-78.

Deaths from cancer in Denmark from 1943-1978 were extracted from the Danish National Death Register at the Danish Institute for Clinical Epidemiology. This paper illustrates the relationship between demographic factors and mortality from a large group of cancers, which increases progressively from young adult life into old age. One-year age-specific mortality rates between 30 and 79 years of age were computed for 14 different cancer sites among both males and females, in five ten-year birth cohorts and for the capital and provinces. The number of deaths at a particular age were found to follow a Poisson distribution and the mortality rate could be expressed by the function lx = bxk, where lx is the mortality rate at age x, and b and k are parameters to be estimated. With this model a straight line is obtained, when mortality and age are plotted on a double logarithmic scale. The maximum likelihood estimates of b and k were found iteratively for each of the 280 combinations of sex--cancer site--residence--cohort. For fixed sex and cancer site the relationship between age, residence and cohort was examined. It appeared that k was independent of residence. For 10 of the male cancers and 12 of the female cancers, k was found to be independent of cohort and in the last 6 cases k was found to be a linear function of cohort. For 12 out of 14 cancer sites among males the ratio of mortality in the capital to mortality in the provinces was significantly greater than one.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

Cardiovascular death and manic-depressive psychosis.

In order to study if tricyclic antidepressant drugs (TCA) in therapeutic doses increase the risk of death due to cardiovascular causes, the relative mortality from cardiovascular diseases was studied in two large groups of first hospitalized manic-depressive patients, one from the TCA era, the other from the period just before the introduction of TCA. Both groups were selected from the Danish Psychiatric Central Register and followed for an average of 4.5 years. Among 2662 manic-depressive men hospitalized between 1969 and 1976, the relative cardiovascular mortality was 1.53 compared to the general population. Among 1133 such cases admitted between 1950 and 1956, the rate was 1.87. Our findings do not support the hypothesis that TCA contribute to the cardiovascular mortality in manic-depressives and even support suggestions that TCA treatment may lower the risk of death by cardiovascular disease, suicide, and other non-cancer causes.

Antidepressive Agents, Tricyclic↗