Biomedical subjects
K Jorgensen
Publications and source records attributed to K Jorgensen.
Histological grading of epidermoid carcinomas in the head and neck.
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Mechano-elastic properties of human muscles at different temperatures.
The effect of changes in the muscle temperature on their ability to store elastic energy was studied by having 5 trained subjects perform maximal vertical jumps on a force platform, with and without counter movement, at muscle temperatures between about 32 degrees C and 37 degrees C. The results showed that the heights of vertical jumps were considerably reduced at lowered temperature, but the gain in height after a counter movement in the form of a jump down from a height of 0.4 m over the force platform, was significantly higher in the cold condition. T o test whether this was due to an increased stiffness of the muscles, experiments with imposed sinusoidal length variations at 14 Hz were performed. Delta force XDelta length-1 (i.e.stiffness) increased with isometric tension independent of muscle temperature. Experiments in which the rate of tension development and relaxation in voluntary maximal isometric contractions were measured at different muscle temperatures showed that maximal isometric tension changed by less than 1% per degree but the rate of tension development and relaxation by 3-5% and 5% per degree, respectively, in the temperature range studied (30 degrees to 40 degrees). These data may be explained by the hypothesis that the series elastic components of the active muscle are located in the cross-bridges between myosin and actin filaments. The storage of elastic energy would be enhanced if the rate of breaking of these bridges were decreased at lower temperatures.
Epidermoid carcinoma of the larynx. VI. Histologic grading in the clinical evaluation.
A multifactorial microscopic grading of malignancy was performed on a clinically well examined series of 129 patients with laryngeal carcinoma. The microscopic score was statistically significantly correlated to the frequency or regional lymph-node metastases and to the death rate. It afforded important supplementary information for the T-classification and for the prognosis. Microscopic grading is an essential supplement to the clinical evaluation of risk groups.
[Spinocellular carcinoma of the lip. A histological-clinical study].
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Radiography of laryngeal carcinoma. Assessment of value.
The value of various radiographic methods (except laryngography) in laryngeal carcinoma was assessed in a material of 71 patients. Radiography proved of no value in T1 and T2 tumours if a satisfactory clinical examination could be performed but gave valuable information in recurrences as well as in T3 and T4 cases.
Carcinoma of the larynx. IV. Recurrences more than 5 years after primary treatment.
The annual frequency of recurrences appearing during the 5th to 10th year of observation was a little more than 1 per cent a year. A formula is described for calculating this frequency. Apart from one case all 12 late recurrences were ordinary recurrences and not new independent tumours. Mortality was almost exclusively attributable to causes other than carcinoma of the larynx.
Carcinoma of the larynx. V. Relationship between biologic effect and failure of irradiation.
Among 147 patients with laryngeal carcinoma, treated with 60Co irradiation and followed for 5 to 10 years, there were 5 cases of recurrence due to incorrectly placed fields. The glottic cases consisted of one group below and one above a Partial Tolerance of 1 650 ret. In the latter group the recurrence rate was significantly lower than in the former. Higher ret levels did not lower the residual tumour or recurrence rate in the glottic group but seemed to lower the rate in the supraglottic group.
Epidermoid carcinoma of the lip. Histologic grading in the clinical evaluation.
A retrospective microscopic evaluation of primary biopsies was carried out in a material of 438 patients with carcinoma of the lip. A multifactorial grading system consisting of 8 parameters, each sub-divided into 4 grades, was used. The degree of malignancy showed a statistically significant correlation to the frequency of metastases, frequency of recurrence or residual tumour, mortality and T classification. This grading system may allow a separation of risk groups in which special treatment and follow-up should be applied.
Epidermoid carcinoma of the tongue. Histologic grading in the clinical evaluation.
In a series of 49 patients with epidermoic carcinoma of the tongue microscopy of the primary biopsy was performed, using a multifactorial grading system consisting of 8 parameters, each of 4 grades. The score value (degree of malignancy) revealed a statistically significant correlation with the frequency of regional metastases. As this was particularly marked in the T1 and T2 groups, it seems to be an important supplement to the clinical evaluation of risk groups.