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Biomedical subjects

K Jones

Publications and source records attributed to K Jones.

At least 343 records · Page 19Linked to original sources
PubMed1990

Psychometric properties of the Social Fear Scale.

The present study attempted to replicate the internal consistency of the Social Fear Scale as well as test-retest, normative and item analysis because these estimates have not been reported. Cronbach alpha s of 0.87 for 38 men and 0.88 for 74 women in college were similar to those reported in 1984 by Raulin and Wee. Test-retest reliability coefficients for the total sample and for each subsample (normative data) indicated strong support for the stability of responses over a 4-wk. period. An item analysis suggested two items may not be useful for assessing social fear. Questions for research are discussed.

Adolescent↗
PubMed1990

Gaining control in a changing environment.

The rapid evolution of home care has frequently produced chaotic and unmanageable situations for home care personnel. This article will assist clinical supervisors with daily operations as they teach their staff how to effectively gain control and stabilize the chaos--how to manage, rather than be managed by, home care.

Community Health Nursing↗
PubMed1989

New delivery systems for asthma drugs.

The therapy of asthma requires great attention to detail by both doctor and patient since the technique of drug administration always needs care. New developments in drug delivery systems for asthma may make this task easier and lead to reduced morbidity.

Asthma↗
PubMed1989

Schizophrenia, tardive dyskinesia, and brain GABA.

We measured the contents of gamma-aminobutyric acid (GABA) and of other amino compounds in five regions of autopsied brain from 18 patients with schizophrenia and from a large group of adult control subjects dying without any neurological or psychiatric disorder. In addition, concentrations of GABA were measured in the cerebrospinal fluid (CSF) of living schizophrenic patients and control subjects. No deficiency of GABA was found in the frontal cortex, caudate nucleus, putamen, nucleus accumbens, or medial dorsal thalamus of patients dying with schizophrenia, nor were GABA concentrations low in the CSF of living schizophrenic patients. These results do not confirm our earlier report of low levels of GABA in the nucleus accumbens and thalamus of some schizophrenic patients. We do not find neurochemical evidence favoring an involvement of GABAergic neuronal hypofunction in the etiology either of schizophrenia or of neuroleptic-induced tardive dyskinesia.

Adult↗
PubMed1989

Parthenogenesis of human oocytes as a function of vacuum pressure.

The effect of different vacuum pressures on the rate of parthenogenesis was studied in 109 cycles of laparoscopic follicle aspiration. A total of 388 follicles was aspirated at settings of vacuum pressure of 100, 75, and 50 mm Hg. Parthenogenesis occurred at the rates of 5.9, 7, and 1%, respectively. The difference between 100 and 50 mm Hg was statistically significant (P less than 0.025). We conclude that the rate of parthenogenesis is influenced by the magnitude of vacuum pressure.

Female↗
PubMed1989

An unusual aminoacidopathy associated with mitochondrial encephalomyopathy.

Five patients from two unrelated pedigrees are affected by an inherited form or forms of mitochondrial encephalomyopathy in which the exact site of the block in the respiratory chain has yet to be identified. All five patients regularly exhibit an unusual aminoacidopathy evident both in fasting plasma and in CSF. Alanine concentrations are elevated, reflecting high tissue pyruvate and lactate levels. Concentrations of the four essential amino acids threonine, methionine, tryptophan and lysine are substantially reduced, as are those of citrulline, ornithine and arginine. This pattern of amino-acid deficiency is apparently not due to failure to absorb the dibasic amino acids, to any abnormality of the urea cycle, to excessive synthesis and turnover of creatine, or to protein malnutrition. The aminoacidopathy presumably is a metabolic consequence of one or more impairments in the electron transport chain in mitochondria. A detailed explanation of its aetiology needs to be sought.

Adolescent↗
PubMed1989

Reducing bone lead content by chelation treatment in chronic lead poisoning: an in vivo X-ray fluorescence and bone biopsy study.

A stained-glass artist with longstanding exposure to lead presented with neuropsychiatric symptoms. He was evaluated before and after chelation treatment by the CaNa2 EDTA lead mobilization test, iliac crest bone lead measurement, and in vivo tibial X-ray fluorescence (XRF). The three methods showed a progressive fall in body lead stores during chelation therapy in association with improvement in symptoms and a fall in blood lead and zinc protoporphyrin levels. In vivo tibial XRF is a safe, rapid, and noninvasive technique for detecting excessive body lead burdens. XRF measurement of bone lead content is a practical method for monitoring the efficacy of therapy as well as for establishing the diagnosis.

Biopsy↗
PubMed1989

Cricothyroidotomy, a useful alternative to tracheostomy in maxillofacial surgery.

Tracheostomy and prolonged intubation are traditionally used in maintaining the airway, particularly after extensive maxillofacial surgery. The literature reports significant morbidity and mortality from both these procedures. Cricothyroidotomy is proposed as a useful alternative in certain circumstances. Recent documentation suggests that traditional fears of subglottic stenosis after cricothyroidotomy are ill-founded. Cricothyroidotomy may also benefit the patient by quicker rehabilitation and in early mobilisation, compared with prolonged intubation. The surgical procedure is quick and easily performed, making it suitable for emergency airway control. Cricothyroidotomy is not appropriate in children or in patients with inflammation to the trachea, since these may predispose to subglottic stenosis.

Cricoid Cartilage↗
PubMed1989

Octreotide suppresses both growth hormone (GH) and GH-releasing hormone (GHRH) in acromegaly due to ectopic GHRH secretion.

Two patients with acromegaly secondary to ectopic GHRH secretion by metastatic carcinoid tumors were studied before and during therapy with the somatostatin analog octreotide (SMS 201-995). GH and GHRH secretory patterns were assessed during intermittent sc administration, continuous sc infusion (CSI), and continuous iv infusion of octreotide. Octreotide reduced serum GH and plasma GHRH levels in the two patients, although there was differential sensitivity of GH and GHRH. Intermittent sc therapy transiently lowered serum GH in both patients. A higher iv dose was required to reduce plasma GHRH by 50% than to reduce serum GH by 50% (2.0 vs. 0.05 micrograms/kg.h, respectively; patient 1). A similar pattern was found during CSI octreotide administration in the same patient. Chronic therapy with intermittent sc and CSI octreotide was assessed by serial 24-h profiles of GH and GHRH secretion in patient 2. Mean hourly serum GH levels decreased from a pretreatment level of 31.5 +/- 3.5 (+/- SE) to 9.5 +/- 1.5 micrograms/L during CSI therapy (1000 micrograms/day or 0.40 micrograms/kg.h). In contrast, plasma GHRH levels were less effectively suppressed. The mean serum GH levels and the variation in hourly GH values were reduced to a greater extent with CSI than with intermittent sc therapy. Serum insulin-like growth factor I also declined from 5.9 x 10(3) to 2.5 x 10(3) U/L during chronic CSI therapy (patient 2). CSI therapy with octreotide can be more effective than intermittent sc therapy in controlling GH excess in the rare syndrome of ectopic GHRH secretion, although serum GH may not decline to normal.

Acromegaly↗