Search PubMed⌕ Search

Biomedical subjects

K Johnson

Publications and source records attributed to K Johnson.

At least 559 records · Page 31Linked to original sources
PubMed1973

The effect of a chemically defined diet on the faecal flora and faecal steroid concentration.

The consumption of a chemically defined diet altered both the faecal flora and faecal steroids. Enterobacteria increased while enterococci and other lactic acid bacteria decreased in number. No other obvious change occurred. However, the alteration in the degree of degradation of the faecal neutral steroids may reflect some alteration in the anaerobic flora. Total excretion of both acid and neutral steroids was also reduced. On cessation of the diet both faecal flora and faecal steroids reverted to levels before the diet.

Bacteroides↗
PubMed1972

Transpeptidase activity of Streptomyces D-alanyl-D carboxypeptidases.

In the presence of N(alpha),N(epsilon)-diacetyl-L-Lys-D-Ala-D-Ala as donor, and either D-[(14)C]alanine, [(14)C]-glycine, or meso-[(3)H]diaminopimelic acid as acceptor, the DD carboxypeptidases from Streptomyces R61 and R39 catalyze a transpeptidation reaction with the release of terminal D-alanine from the donor and the formation of either N(alpha),N(epsilon)-diacetyl-L-Lys-D-Ala-D-[(14)C]Ala, N(alpha),N(epsilon)-diacetyl-L-Lys-D-Ala-[(14)C] Gly, or N(alpha),N(epsilon)-diacetyl-L-Lys-D-Ala-D-meso- [(3)H]diaminopimelic acid. The reaction appears to be a true transpeptidation, and is not simply a "reversal of hydrolysis". Transpeptidation is inhibited by pencillin at concentrations that inhibit hydrolysis (carboxypeptidase action) of the donor peptide. There are differences in the specificity profiles of the Streptomyces enzymes for acceptor molecules:only the R61 enzyme used [(14)C]Gly-Gly as acceptor; transfer of N(alpha),N(epsilon)-diacetyl-L-Lys-D-Ala to this acceptor resulted in the formation of N(alpha),N(epsilon)-diacetyl-Lys-D-Ala-[(14)C] Gly-Gly, with the synthesis of a (D-Ala-Gly) peptide bond in an endoposition.

Alanine↗
PubMedDate not supplied

Building capacity through collaborative leadership.

This paper is based upon material from the manuals and training program underpinnings the 'Sustaining community-based initiative' from the Healthcare Forum with the W.K. Kellogg Foundation in the USA. In order to address the problems of American urban communities a new approach is proposed using the concept of 'collaborative empowerment'. This is a planning and organizational method that lets community- and neighbourhood-based organizations design, implement and assess problem-solving strategies that increase their effectiveness at dealing with community issues. The use of organizational management principles and practices in community involvement and strengthening community leadership is illustrated through practical examples.

Community Health Planning↗
PubMedDate not supplied

Motivation and the coping process of adults with disabilities: a qualitative study.

Adults with disabilities who have completed rehabilitation programs and have returned to active lifestyles are experts on the importance of motivation after an injury or an illness. This qualitative descriptive study was conducted with 9 men and 3 women who had completed a spinal cord injury rehabilitation program at a rehabilitation hospital. The subjects were asked two questions: What helped motivate you during rehabilitation to return to an active, productive life? and How did rehabilitation nurses and staff assist you with that process? An analysis of the interviews revealed five motivational categories--independence, education, socialization, self-esteem, and realization--within the specific themes of nursing and healthcare interventions. Gaining insight into the motivation of adults who have coped with disabilities effectively can help rehabilitation nurses determine how they can promote the motivation that clients need to achieve a quality lifestyle.

Activities of Daily Living↗