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Biomedical subjects

K Javorka

Publications and source records attributed to K Javorka.

At least 73 records · Page 4Linked to original sources
PubMed1977

Contribution to the etiopathogenesis of orthostatic proteinuria in children.

The results of sequential scintigraphy of the kidneys of 22 children with orthostatic proteinuria and of 25 patients with nephritis or nephrotic syndrome, respectively, have been evaluated. At particular time intervals significant differences have been found between the two groups. On the basis of the visual method of evaluation of scintiscans and by bilateral comparison the authors conclude that in children with orthostatic proteinuria the frequency of asymmetry of the kidneys was significantly higher. These changes were most likely due to spasms or other disturbances of the function of excretory urinary passages in the calyx-pelvis system as responses to unfavourable emotional inpulses (intravenous application of the substance, etc.) and to the sitting position during the examination.

Adolescent↗
PubMed1977

Pulmonary haemodynamics during nasal apnoea in rabbits.

Changes in pulmonary haemodynamics, produced during stimulation of the nasal mucosa with xylol fumes, were found in experiments on anaesthetized rabbits. In spontaneously breathing animals, a decrease in the mean blood pressure in the pulmonary artery and an increase in the mean blood pressure in the left atrium occurred in addition to apnoea and bradycardia. Pulmonary vascular resistance fell significantly, whereas systemic vascular resistance rose. Changes in the pulmonary circulation during nasal stimulation in spontaneously breathing rabbits did not differ significantly from changes in artifically ventilated animals.

Animals↗
PubMed1976

Role of the autonomic nervous system in the development of cardiovascular changes during nasal apnoea and lung inflation.

The role of the sympathetic system in the development of bradycardia during nasal apnoea and the role of the sympathetic and parasympathetic system in the development of cardiovascular changes during and immediately after lung inflation were determined in anaesthetized rabbits. Transection of the cervical cord (C5-7) completely blocked the hypertensive response to chemical stimulation of the nasal mucosa. The degree of nasal bradycardia was 72% lower than in stimulation of the controls. Propranolol had no effect on the hypertensive reaction, but inhibited nasal bradycardia, which was 68% lower than in the controls. Lung inflation induced tachycardia, which was only non-significantly reduced by bilateral vagotomy. Vagotomy inhibited the bradycardiac response to removal of occlusion of the trachea and the subsequent rise in blood pressure, however. Cervical cord transection likewise did not reduce inflation-induced tachycardia, but it significantly influenced the heart rate during the second phase of prolonged inflation, when the heart is affected by hypoxia. Inflation-induced tachycardia was likewise not influenced by bilateral vagotomy associated with cervical cord transection. Similar cardiac responses also occur in the presence of the simple increase in pericardial pressure produced by left pneumothorax without lung inflation.

Animals↗
PubMed1975

Cardiovascular, respiratory and glottic effects of sodium salicylate administered into different parts of the circulation in rabbits.

The authors studied the effect of sodium salicylate administered into different parts of the circulatory system on various cardiovascular, respiratory and glottic parameters in Pentobarbital-anaesthetized rabbits. The results show that apnoea, bradycardia and hypotension, followed by hypertension, can also be caused by the extrathoracic action of salicylate. Cardiovascular responses induced by injecting salicylate into the carotid circulation are qualitatively the same, even after vagotomy, as in injection into the femoral vein. Salicylate injected into the common carotid artery, the internal carotid artery or the femoral vein causes inspiratory apnoea in rabbits, with powerful electrical activity of the diaphragm and an intrapleural pressure shift to marked inspiratory values. Laryngoconstriction occurs simultaneously, despite inspiratory apnoea. The injection of salicylate into the common carotid artery after bilateral vagotomy induces expiratory (not inspiratory) apnoea, indicating that the vagi play an important role in the origination of inspiratory apnoea in rabbits.

Animals↗