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Biomedical subjects

K Jacobs

Publications and source records attributed to K Jacobs.

At least 91 records · Page 5Linked to original sources
PubMed1980

Adrenomyeloneuropathy and adrenoleukodystrophy in two brothers.

A 19-year-old patient presented with spastic paraparesis and peripheral neuropathy without clinical or biochemical signs of adrenal insufficiency. The diagnosis of adrenomyeloneuropathy was supported by typical ultrastructural findings in peripheral nerve and endomysial nerve bundles and by a positive family history. Indeed his younger brother died at age 12 from a demyelinating disease of the central nervous system. Cutaneous nerve bundles and postmortem examination limited to the brain demonstrated features specific for adrenoleukodystrophy. The various features of both disorders are discussed. Their occurrence in the same sibship pleads strongly for a very close relationship.

Adrenal Insufficiency↗
PubMed1980

Protease and antiprotease responses in lung and peripheral blood in experimental canine pneumococcal pneumonia.

We studied the effects of pulmonary infection with type III pneumococcus in dogs on the degree of granulocyte elastase-like esterase activity and on the degree of antiproteases in peripheral blood and lung lavage fluid. In 9 infected dogs the peripheral blood granulocyte esterase activity increased from a preinfection level of 361.3 +/- 51 units/10(8) leukocytes to 593.8 +/- 80 units/10(8) leukocytes (mean +/- SE) 24 h after pneumonia had been induced (p less than .02). Parallel changes were measured in granulocytes obtained from bronchial lavage fluid. The antitrypsin activity and esterase inhibitory activity of peripheral blood increased by 15% after infection was induced. The esterase inhibitory activity of lung lavage fluid increased from a preinfection level of 776 +/- 160 units/mg of lavage protein to 1,390 +/- 200 units/mg of lavage protein (p less than .05). These findings indicate that whereas both circulating and lung lavage granulocytes contain increased concentrations of proteolytic activity during infection, serum antiproteases and, to a larger extent, lung antiproteases, also are increased.

Animals↗
PubMed1975

[The blind as a factor in the labour divisioned world (author's transl)].

The problems faced by blind adolescents when leaving special schools to enter employment differ considerably from those encountered by people who lost their sight during adulthood. The realisation of the fact that their blindness leaves little occupational choice often results in job apathy. It is, however, especially work capacity and occupational activity which serve again and again, in discussions on the full integration of the blind, as proof of the visually impaired's equal position within society. In particular W. Thimm has proved that blindness has a decisive impact on the social position of the individual blind person as well as the whole disability group of the blind, because this is essentially determinated by the employment status. The individual job performance of some blind is generalised too rapidly. The fear that jobs carried out by the blind are jeopardised by the increasing automation is certainly not unfounded, especially in large enterprises. At present, however, it is not possible to make a prognosis on whether in the future job opportunities for the blind will be available or not in certain branches of industry or in specific branches of production (this varies from one firm to another and is dependent upon many other factors). Consequently, it seems to be necessary for institutions involved in the vocational training of the blind to adjust in due course to the new situation in the theoretical and practical implementation of rehabilitation.

Blindness↗
PubMedDate not supplied

A reforming accountability: GPs and health reform in New Zealand.

Over the last ten years or so, many countries have undertaken public sector reforms. As a result of these changes, accounting has come to play a more important role. However, many of the studies have only discussed the reforms at a conceptual level and have failed to study how the reforms have been implemented and operated in practice. Based on the work of Lipsky (1980) and Gorz (1989), it can be argued that those affected by the reforms have a strong incentive to subvert the reforms. This prediction is explored via a case study of general practitioner (GP) response to the New Zealand health reforms. The creation of Independent Practice Associations (IPAs) allowed the State to impose contractual-accountability and to cap their budget exposure for subsidies. From the GP's perspective, the IPAs absorbed the changes initiated by the State, and managed the contracting, accounting and budgetary administration responsibilities that were created. This allowed individual GPs to continue practising as before and provided some collective protection against the threat of state intrusion into GP autonomy. The creation of IPAs also provided a new way to manage the professional/financial tension, the contradiction between the professional motivation noted by Gorz (1989) and the need to earn a living.

Budgets↗