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Biomedical subjects

K J Mutton

Publications and source records attributed to K J Mutton.

30 records · Page 2Linked to original sources

Influenza in Melbourne, 1982. Epidemiology and virology.

The major features of the outbreaks of influenza A and B, which occurred in Melbourne during the winter of 1982, are described. Diagnoses of influenza A or influenza B were established in 310 patients by virus isolation, immunofluorescence, and serological tests. Immunofluorescence was found to be a valuable, rapid, but considerably less sensitive, test than virus isolation, and serodiagnosis was the test of choice either when patients did not present or when specimens were not collected until late in the illness. The results of haemagglutination-inhibition tests performed with a panel of monoclonal antibodies suggest that at least two recognizably different strains of influenza A and influenza B were circulating in the community.

Adolescent↗

Intra-abdominal pneumococcal abscess.

A 25-year-old woman with the adrenogenital syndrome was admitted to hospital because of abdominal pain. Streptococcus pneumoniae was present in pus obtained from an abscess in the appendix area.

Abdomen↗

In vitro activity of pristinamycin against methicillin-resistant Staphylococcus aureus.

An agar dilution technique was used to determine the MIC of pristinamycin for 124 clinical isolates of methicillin-resistant Staphylococcus aureus. All were inhibited by less than or equal to 0.5 mg/1, quite similar to the sensitivity of a number of methicillin-sensitive strains. MICs obtained using a microdilution method were also comparable. Antagonism was seen with the combination of pristinamycin and erythromycin.

Anti-Bacterial Agents↗

Antibiotic susceptibility of Staphylococcus aureus community acquired strains.

Over 250 strains of Staphylococcus aureus isolated from patients who presented with infections acquired outside the hospital were tested for susceptibility to penicillin G, minocycline and erythromycin. Only 15.5% of strains could be regarded as sensitive to penicillin, whereas 99.2% and 90.2% were sensitive to minocycline and erythromycin respectively. Beta-haemolytic streptococci were found in association with Staph. aureus in 17.5% of the lesions cultured in this survey. The susceptibility of a further 100 strains of methicillin-sensitive Staph. aureus to a wider range of antimicrobial agents was also examined.

Anti-Bacterial Agents↗

Serratia cross-infection in an intensive therapy unit.

During a 10-week period, 11 patients were involved in an outbreak of cross-infection with a non-pigmented strain of Serratia marcescens resistant to sulphonamides, trimethoprim, ampicillin, tetracycline, chloramphenicol, cephalexin, gentamicin, tobramycin, colistin, ticarcillin and kanamycin. The problem was confined to the intensive therapy areas of the hospital. The organism was apparently spread by a nursing sister who harboured it in a paronychial lesion. Prolonged carriage of S. marcescens was demonstrated. Methods of investigation of the outbreak and the measures adopted to terminate it are described.

Aged↗

Antibacterial activity of five cephalosporins.

The in vitro susceptibilities of 7 commonly isolated species of bacteria to cephalothin, cefoxitin, and 3 new cephalosporins--cephamandole, cefuroxime, and cefoperazone--were studied using an agar dilution method. Cephalothin and cephamandole were the most active agents against staphylococci. Against members of the Enterobacteriaceae all the newer agents were more active than cephalothin; however, important individual differences emerged. Only cefoperazone had significant activity against Pseudomonas aeruginosa.

Bacteria↗

Disseminated fusarium infection.

A case of disseminated Fusarium sp. infection in a bone-marrow transplant patient is described. The most likely source of the organism was food, and the importance of a specially prepared diet in immunosuppressed individuals is emphasized.

Adult↗