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Biomedical subjects

K J Connolly

Publications and source records attributed to K J Connolly.

36 records · Page 2Linked to original sources
PubMed1991

The effects of parasite infections on cognitive processes in children.

Two studies were carried out in the Nyuswa area of Natal to investigate the effects of parasitic infection on cognitive function in children. In the first study, children infected with intestinal helminths were given tests of information processing and perceptual speed before and after treatment with a single 500 mg dose of Mebendazole. The pattern of results was consistent with the hypothesis that parasitic infections combine with nutritional deficits to impair the efficiency of cognitive processes. There was, however, some confounding of variables, and the single drug treatment reduced but did not eliminate the parasites. The second study removed the confounding effects due to age and nutrition and employed a more comprehensive drug-treatment programme. A memory task and a test of sustained attention were administered. Poor performance on the attention task showed a significant association with parasite status, but no association was observed with educational attainment or memory function. The study also examined various ways of assessing parasite load, and an index weighted for estimated pathogenicity was found to give the best estimate. The results provide evidence of the effects of parasitic infection on attentional processes.

Age Factors↗
PubMed1991

Effects of maternal iodine supplementation during pregnancy.

Reduced maternal thyroid hormone concentrations during pregnancy can adversely affect fetal neurological development. In the context of national iodine supplementation programmes, concern has been expressed over the theoretical possibility that iodine supplementation during pregnancy might adversely affect fetal development as a result of maternal thyroid inhibition from the Wolff-Chaikoff effect. In a double blind controlled trial in five villages in Papua New Guinea, several measures of motor and cognitive function showed no significant differences at either age 11 or 15 years between those children whose mothers had received supplementary iodine during pregnancy and the control children whose mothers had received the placebo.

Adolescent↗
PubMed1990

The acute aseptic meningitis syndrome.

The acute aseptic meningitis syndrome is an entity that presents a diagnostic challenge to the clinician. Although many infectious and noninfectious etiologies exist for this syndrome, viruses, especially nonpolio enteroviruses, are the classic and most important agents encountered. The incidence of polio and mumps meningitis has declined dramatically in the vaccine era, but recently described pathogens, such as human immunodeficiency virus and Borrelia burgdorferi (Lyme disease agent) are now important considerations in the differential diagnosis. Specifically treatable entities (eg, mycobacterial or fungal meningitis, herpes simplex encephalitis, parameningeal infection) that may mimic aseptic meningitis in their initial presentations must not be overlooked. A careful approach to the patient and a rational use of laboratory studies are the basis for establishing a specific diagnosis and assuring a favorable outcome.

Acute Disease↗
PubMed1988

Development of kinaesthetic sensitivity and motor performance in children.

Kinaesthetic acuity of 100 children, aged from four to 13 years, was assessed and a developmental trend is described. The relationship between kinaesthetic acuity and motor performance on a range of motor tests commonly used for assessing children was also examined, and contrary to expectation no evidence of a relationship was discovered. There is little reported evidence for this relationship in the literature, and some possible reasons for this are discussed. A staircase procedure for threshold estimation was used and is described in detail.

Adolescent↗
PubMed1987

A controlled trial of iodinated oil for the prevention of endemic cretinism: a long-term follow-up.

A double blind controlled trial designed to examine the effectiveness of intramuscular iodinated oil as a prophylactic for the nervous type of endemic cretinism was begun in 1966 in the highlands of Papua New Guinea. Infants born into the trial between 1966 and 1972 were followed up until 1982. The results showed that if the iodine supplement was given before conception the nervous form of endemic cretinism was prevented. Also a striking difference in the 15-year cumulative survival rate in favour of the test (iodinated oil) group was observed. Measures of motor and intellectual function revealed that children born to mothers given an iodine supplement performed significantly better. This observation shows that iodine deficiency leads to sub-clinical as well as clinical deficits. It also justifies the use of the term iodine deficiency disorder to cover the polymorphic nature of the abnormalities attributable to iodine deficiency.

Adolescent↗
PubMed1986

Psychological aspects of infertility.

It has often been claimed that psychological problems accompany infertility among some couples attending infertility clinics. Some authors have suggested that psychological factors may be a primary cause of infertility, others have suggested that the state of infertility itself can provoke psychological symptoms. The importance of psychological counselling for involuntarily childless couples has also been noted. This paper, which reviews studies that have attempted to investigate psychological aspects of infertility, is organized around three issues: psychological factors as a cause of infertility, the impact of infertility on psychological functioning, coping with infertility and the counselling needs of the infertile couple. While there seems little doubt that infertility has psychological consequences for some couples, many questions will remain unanswered unless carefully designed and conducted longitudinal studies are undertaken.

Adaptation, Psychological↗
PubMed1986

Measurement of kinaesthetic sensitivity.

Two recent papers (Laszlo and Bairstow 1980, Bairstow and Laszlo 1981) have used the method of constant stimuli to measure kinaesthetic difference thresholds. If this method is used, however, certain constraints must be observed: these concern the values of the stimuli relative to the threshold, and the numbers of observations made at each value. Laszlo and Bairstow appear to have neglected these constraints, which must cast doubt on their results. In any case, the method of constant stimuli has largely been superseded by staircase techniques for threshold estimation, on grounds of economy of trials for a given level of accuracy in estimation. It is concluded, therefore, that the details of the method as described by Laszlo and Bairstow are unsuitable for testing kinaesthetic sensitivity, and that other methods are preferable.

Humans↗
PubMed1984

Maternal thyroid hormone levels in pregnancy and the subsequent cognitive and motor performance of the children.

Serum levels of thyroxine and triiodothyronine during pregnancy were measured in women from a severely iodine deficient region in the highlands of Papua New Guinea. Subsequently the children born to these women were examined when aged 10-12 years and measures made of intellectual ability and motor competence. A significant correlation between these measures in the children and the maternal thyroxine but not maternal triiodothyronine level was observed. It is speculated that maternal thyroxine and not triiodothyronine may be essential for normal neurological maturation of the fetus before the fetal thyroid becomes functional.

Child↗
PubMed1984

A classification of manipulative hand movements.

The nature of manual manipulation of objects is discussed. It is argued that a functional distinction should be made between palmar grips which immobilise an object in the hand, and digital patterns which permit manipulation. Such a distinction is separate from any anatomically defined power and precision configurations. Manipulative hand movements may be grouped into three classes, based on differences between sequenced patterns of movement and synergies, the latter being further subdivided into simple and reciprocal patterns. Within each of the three classes, a number of individual movement patterns are described. These differ mainly in the number of digits involved and the way in which the thumb is employed. The classification is concerned with movements of the digits directed at manipulating an object within the hand. It is not concerned with movements of the hand as a whole, using the wrist or more proximal joints, while holding an immobilised object.

Child↗
PubMed1979

Fetal iodine deficiency and motor performance during childhood.

Motor performance of children born to mothers living in an iodine-deficient region was assessed. The mothers were participants in a controlled trial of intramuscular iodised oil in the prevention of endemic cretinism carried out in the Western Highlands of Papua New Guinea. Mothers received either iodised oil or placebo saline. Children born to mothers given iodine were significantly faster and more accurate in tests of manual function than children from control mothers. The findings indicate that iodine deficiency may lead to a spectrum of subclinical deficits which place the children at a developmental disadvantage.

Child↗
PubMed1978

The effect of visual frame of reference on a judgement of plane stimulus orientation by children.

Three studies are reported with children aged 4 1/2 to 9 1/2 years and also with educationally subnormal children, in which it was found that up to about 7 years children's selection of one of a pair of line stimuli as 'falling over' is affected by the nature of the visual surround contours provided. Both the form of the stimulus surround and the presence or absence of a baseline tilted 45 degrees relative to the horizontal were found to affect the children's judgements. The plane (horizontal or vertical) in which the stimuli were presented had no effect on the results. It is argued that while the results show the influence of the visual surround on children's comprehension of 'falling over', this may not be wholly explicable in terms of surround contour matching, as conventionally correct judgements were obtained in the absence of all straight line contours in the immediate surround.

Age Factors↗
PubMedDate not supplied

Relationship between maternal thyroxine levels during pregnancy and memory function in childhood.

Two investigations are reported into the memory functions of a group of subjects for whom information on maternal thyroxine (T4) levels during pregnancy is available. The first study made when the subjects were aged 14-15 years examined forward and backward memory span. No relationship between maternal T4 levels and capacity of the short-term store, measured as length of forward memory span, was found. Backward memory span, which involves performing a mental operation on the material held in store, was found to be associated with maternal T4 level. The second study, made when the subjects were aged 16-17 years, found a relationship between maternal T4 levels during pregnancy and memory for serial position. Findings are discussed in terms of the role of maternal thyroxine in fetal brain development.

Adolescent↗