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Biomedical subjects

K J Cho

Publications and source records attributed to K J Cho.

At least 109 records · Page 6Linked to original sources

Digital subtraction venography of the upper extremity.

Seventy four digital subtraction venograms of the upper extremity and mediastinum were performed in 69 patients. The indications included idiopathic arm and shoulder swelling, difficulties with a central venous catheter, chronic venous access device, or dialysis fistula, superior vena cava syndrome, or pre-operative anatomical mapping. Clinically useful information was obtained in all studies. The digital subtraction technique allows the simple and rapid performance of venography, especially in patients with limited venous access.

Adult↗

Preoperative devascularization of advanced renal adenocarcinoma using a sclerosing agent.

Sodium tetradecyl sulfate is a sclerosing agent used currently as therapy for varicose veins. Animal experiments have demonstrated this drug to be a useful agent for renal tissue destruction. We have used sodium tetradecyl sulfate with or without steel coils for preoperative renal devascularization in 6 patients with advanced renal adenocarcinoma. In all patients sodium tetradecyl sulfate effectively caused renal infarction and was tolerated well. No complications were associated with the use of this agent. Sodium tetradecyl sulfate is an efficient fluid embolic agent that can be a useful adjunct to nephrectomy in selected cases.

Carcinoma, Renal Cell↗

Local thrombolytic therapy for hepatic artery thrombosis following chemotherapy infusion catheter placement.

Nine patients with hepatic artery thrombosis subsequent to catheter placement (four surgical and five percutaneous) for hepatic arterial infusion chemotherapy were treated with local thrombolytic therapy. The thromboses were located in the common hepatic, proper hepatic and hepatic arteries. Thrombolytic therapy was instituted within seven days of catheter placement, at a rate of 5,000 to 20,000 units/hour (streptokinase) or 5,000 to 15,000 units/hour (urokinase) for 15 to 64 hours. All patients had repeat angiography and 99mTc-MAA hepatic artery perfusion scintigraphy after the infusion. In eight of the patients, thrombolytic therapy resulted in dissolution of the thrombus and recanalization of the hepatic artery. In three of these patients, rethrombosis occurred within a few days, and was attributed to underlying arterial abnormalities. The other five had documented continued hepatic arterial patency allowing completion of the chemotherapy course. The patient who did not respond to the lytic therapy had developed extensive collateral flow through the gastroduodenal artery to the liver.

Adult↗

Crohn's disease--a case report.

A case of rather typical Crohn's disease in a 10 year old girl is described. She had suffered from intractable abdominal pain, diarrhea and fever for 1 year. Eventual right hemicolectomy revealed diffuse involvement of terminal ileum, cecum and ascending colon by confluent ulcerations and transmural inflammation. Histologically there were numerous well developed non-caseating granulomas scattered transmurally and in regional lymph nodes. Deep penetrating ulcerations were characteristic. Acid fast staining failed to demonstrate any organism. The rarity of Crohn's disease in Korea and this occurrence in pediatric age prompted this report.

Child↗

Intramural sparganosis manifested as intestinal obstruction--a case report.

A case of intramural sparganosis of jejunum presenting as intestinal obstruction is described. Resected intestine from a 48 year old man with acute abdomen revealed a degenerated sparganum in the submucosa with typical tissue reaction and extensive edema. The tissue reaction was basically granulomatous, consisting of layers of inner palisading histiocytes and outer mononuclear cell infiltration. Many calcospherules were prominent within the degenerated worm. Eosinophil infiltration was scanty.

Granuloma↗

Assessment of anterior shoulder instability by CT arthrography.

Computed tomography (CT) immediately after double-contrast shoulder arthrography was taken in twenty-two young male patients with anterior shoulder instability including recurrent dislocation and subluxation. This recently developed technique called CT arthrography can provide significant information about patients with glenohumeral instability which is difficult to obtain by conventional arthrography. Information about glenoid labrum pathology is useful for proper management of the shoulder with instability. Lesions identified in this study include anterior labral defects (attenuation, tear, displacement), anterior capsular distension and/or detachment, Hill-Sachs lesion, anterior glenoid rim compression fracture, and fracture of scapula. This article describes the method used in CT arthrography of the glenohumeral joint, reviews the normal cross-sectional anatomy, and emphasizes the importance of the application of CT arthrography in the shoulder disorder with instability. CT arthrography of the glenohumeral joint is easy to perform, is accurate, and has lower radiation dose than arthrotomography.

Adult↗

Intracranial granulocytic sarcoma (chloroma) in a nonleukemic patient.

Chloroma is a granulocytic sarcoma with it's characteristic greenish color. Recently there is an increased number of cases that are apparently aleukemic when the tumor mass is first presented. Recently we experienced a case of granulocytic sarcoma with characteristic green color (chloroma), which showed no evidence of leukemia in the bone marrow and peripheral blood. This patient presented headache, and was diagnosed brain tumor on computed tomography. A left parietal cranietomy was done to remove a large central dome-like mass, 8 cm, involving the dura with a slightly dusky greenish solid appearance. Compact nests of moderately mature granulocytes and immature cells comprised the tumor. Histochemical and electron microscopic studies confirmed these tumor cells as myeloid cells in varying stages of maturation. Several days after the operation, left cervical lymph nodes became palpated, and the biopsied lymph nodes revealed same neoplastic cells seen in the skull. However, bone marrow aspiration, biopsy and peripheral blood smears did not show any evidence of leukemia.

Adolescent↗

Infantile hemangioendothelioma of the liver--a case report.

A case of type 1 infantile hemangioendothelioma of the liver in a 3 month old male infant who had an abdominal mass incidentally noted at 40 days of age, is described. Grossly, the tumor showed a well circumscribed, pinkish gray and gelatinous mass with areas of central necrosis, multifocal thrombi and hemorrhages, and small cysts. Microscopically, the lesion consisted of numerous vascular channels of various size lined by a single layer of flat or plump endothelial cells. Areas of infarction, thrombosis and calcification, and formation of cavernous hemangiomatous foci were also noted in the lesion. Ultrastructurally, the cells had the characteristics of endothelium, including basal lamina, pinocytic vesicles, and Weibel-Palade bodies. Factor VIII-associated antigen was demonstrated in the tumor cells.

Hemangioendothelioma↗

Malignant lymphomas in Korea.

A retrospective histological study of 540 malignant lymphomas diagnosed at the Department of Pathology of the Seoul National University from 1976 through 1986 is presented. Malignant lymphoma is the 10th most common malignant tumor in Korea, comprising 3.07% of all malignancy during period of study. Among malignant lymphomas non-Hodgkin's lymphoma accounted for 82% and accordingly the Hodgkin's disease was for 18%. The most common type of non-Hodgkin's lymphoma was diffuse histiocytic lymphoma of Rappaport. Follicular lymphoma was very rare, comprising only 2.3%. T-cell lymphoma accounted for 9.6% of non-Hodgkin's lymphomas, the most frequent type being lymphoblastic lymphoma. Immunoblastic sarcoma and mycosis fungoides were occasionally seen but there was no case of pleomorphic adult T-cell lymphoma. Among Hodgkin's diseases, mixed cellularity type was the most common type, and nodular sclerosis type was relatively rare.

Adolescent↗

Diagnosis and management of congenital cystic disease of the lung in children.

Pulmonary sequestration, congenital adenomatoid malformation (CAM), congenital lobar overinflation (CLO), and bronchogenic cysts are four congenital lesions that may present as abnormal cystic areas within the pleural cavity in early life. They share similar clinical and embryologic characteristics, are frequently difficult to diagnose, and all require surgical treatment. From December 1974 to January 1985, 22 patients were operated upon on the Pediatric Surgical Service for congenital cystic disease of the lung. There were eight females and 14 males, ranging in age from 1 day to 18 years; 12 were under 6 months of age, and 14 were under one year. There were 7 CAMs, 5 extralobar pulmonary sequestrations, 5 intralobar pulmonary sequestrations, 3 bronchogenic cysts, and 3 cystic lobes caused by CLO. One patient had bilateral pulmonary sequestrations, intralobar on one side and extralobar on the other, with both sharing a common systemic artery arising from the infradiaphragmatic aorta. All except two asymptomatic patients presented with either progressive respiratory distress or recurrent pulmonary infections, and had cystic changes noted on chest roentgenograms. The differentiation of these congenital lesions from resolvable inflammatory cysts is important. Diagnosis was aided by selective utilization of barium contrast studies, ultrasonography, computed tomography, and arteriography. Operation consisted of resection alone of the extralobar pulmonary sequestrations and bronchogenic cysts, and total lobectomy in CAM, intralobar sequestration, and CLO. One infant with CAM died 1 day postoperatively from bilateral hypoplastic lungs. The other 21 patients are alive and well with follow-up ranging from 1 month to 9 years, with a mean of 3.5 years.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

Chemical ablation of the canine kidney using sodium tetradecyl sulfate (Sotradecol). A histopathologic study.

We studied the histopathologic effect of intraarterial Sotradecol (Elkins-Sinn, Inc., Cherry Hill, NJ) on the kidney and examined the mechanism for destruction of renal parenchyma by Sotradecol. Sotradecol was injected into one renal artery distal to an occlusion balloon catheter in six dogs, and the kidneys were removed for histologic examination; four dogs within 20 minutes, and one each at 12 and 24 hours after embolization. The contralateral kidney of each dog underwent the same procedure but was injected with normal saline, and served as control. Histologic examination of the control kidneys was unremarkable. The embolized kidneys revealed extensive endothelial denudation and mural necrosis of the arteries and coagulation necrosis of the renal parenchyma. The changes were evident as early as 20 minutes after embolization, and necrosis became complete by 24 hours. The arteries were filled with red blood cell sludge. Sotradecol produces extensive tissue necrosis and complete renal parenchymal destruction through its direct cytotoxic action on the arterial wall, blood cell elements, and renal parenchyma.

Angiography↗

Hepatic falciform artery: anatomy, angiographic appearance, and clinical significance.

Three patients developed supraumbilical skin rashes during hepatic artery infusion chemotherapy by a surgically placed perfusion catheter and drug-infusion pump. In one patient, hepatic arterial scintigraphy with technetium-99m macroaggregated serum albumin showed increased uptake corresponding to the rash, and a hepatic arteriogram showed a dilated falciform branch of the left hepatic artery. Surgical ligation of the falciform artery permitted further treatment without recurrent rash. Based on a review of 100 celiac arteriograms, the incidence of the falciform artery on angiographic studies is approximately 2%. The angiographic appearance of this artery is presented, and its potential clinical significance in hepatic artery perfusion chemotherapy is discussed.

Abdominal Muscles↗

Portal hypertension evaluated by MR imaging.

Thirteen patients with portal hypertension were examined by magnetic resonance (MR) imaging, using spin-echo sequences, and by visceral angiography. Data from this group were compared with the MR images and angiograms of 20 patients without portal hypertension. MR imaging demonstrated two of three cases of portal vein occlusion and four of five cases of occlusion of the retropancreatic portion of the superior mesenteric vein. Two thirds of the patients with portal hypertension and patent portal veins had marked MR signal within the main portal vein on MR images. Little or no signal was present in the portal veins of the 20 patients without portal hypertension. Our experience indicates that marked intraportal MR signal can be seen in patients with portal hypertension with or without venous occlusion. In some cases the size and distribution of venous collaterals allow one to distinguish between venous occlusion and other causes of portal hypertension. MR images confirmed the patency of distal splenorenal shunts in two patients studied.

Adult↗

Inferior mesenteric artery aneurysms.

Two patients were treated for asymptomatic aneurysms of the inferior mesenteric artery during reconstructive operation for infrarenal aortic disease. These lesions were discovered incidentally during arteriographic study in one case and during operation in the second case. Including these two patients, the number of reported inferior mesenteric artery aneurysms now totals 13. The etiology, manifestations, and treatment of the currently reported aneurysms are compared with eight previously published cases in which detailed clinical data were presented. Although the natural history of these rare aneurysms remains undefined, operative intervention appears appropriate for all mycotic lesions and certain other aneurysms, such as those in patients undergoing aortic operation.

Adult↗

Traumatic pseudoaneurysms of the thoracic aorta. Anatomic and radiologic correlations.

Long-term survivors with traumatic ruptures of the aorta that are not detected at the time of injury manifest pseudoaneurysms. We reviewed a ten-year experience with pseudoaneurysms of the thoracic aorta to correlate anatomic and roentgenographic findings in this unusual group of patients. Eleven patients, who were 28 to 65 years of age, had abnormal chest findings one to 36 years after their injuries. Nine patients had calcification that was visible on the plain chest film, and two patients had calcification that was visible on computed tomography. Nine of the 11 pseudoaneurysms, all of which were distal to the left subclavian artery, were saccular and involved only the medial aspect of the aortic wall. Anatomically, they appeared to have been confined in a space bordered by the mediastinal pleura, pulmonary artery, left mainstem bronchus, and normal aorta. Pseudoaneurysms that occur on the medial aortic wall at the level of the ligamentum arteriosum may be more stable because of anatomic confinement by stable adjacent structures.

Adult↗

Angiographic patterns of involvement in renal and perirenal lymphoma.

Ten patients with renal lymphoma studied by selective angiography are reported. Seven patients had unilateral and 3 had bilateral involvement. A localized mass was seen in 6 patients and diffuse infiltration in 3. In 1 patient with bilateral nodular involvement, the angiographic findings resembled those of adult-type polycystic kidney disease. In all cases, renal lymphoma was suspected angiographically. The findings included hypovascular mass or masses with fine neovascularity, smooth and diffuse arterial encasement, and faint tumor staining.

Adult↗