Hepatic injury associated with itraconazole.
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Biomedical subjects
Publications and source records attributed to K J Balmus.
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We have made a non-selective search for patients undergoing treatment for more than five years for an arterial deficiency of the lower limbs. Most of the patients studied suffered from intermittent claudications for which surgical treatment was impossible (distal lesions, diabetes, coronaritis) or had failed (sympathectomy, recurrences). Faced with the inefficiency of vasodilators, and in addition to strict medical treatment of the risks factors of arterio-sclerosis disease (tobacco, obesity, hypercholesterol, sedentary habits), we treated these patients using intra-arterial injections according to the method of Reboul. Our patients generally received one injection per week of xylocaine-priscol-pronestyl. Once an improvement appeared, these injections were spaced out so as to become semi-annual. We grouped 67 patients suffering from intermittent claudications and 5 patients suffering from arteritis ulcers. We studied the results obtained from this so-called palliative treatment (the claudication going from an average 201 meters to 3,395 meters after five years and cure of the ulcers).
The discovery of a femoral artery that is clinically non palpable can be made using the Doppler. It is thus possible to use a direct intra-arterial treatment. This is what was done by the authors, who thereby divided the patients into two groups: the first, 22, with non palpable femoral arteries; the second, 20, with palpable femoral arteries. They obtained good results with intermittent claudications, with increase of the walking perimeter, and among the trophic problems they noted, an increase of the walking perimeter, and among the trophic problems they noted, an increase in arterial pressure on the limbs in question, a phenomenon of which they discuss the pathogenic causes.