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Biomedical subjects

K Ishihara

Publications and source records attributed to K Ishihara.

At least 793 records · Page 44Linked to original sources
PubMed1980

[Skin potential activity under two electrode electrolytes].

To examine whether the basal skin potential levels (BSPL) obtained from habituated and relaxed subjects are determined by a relationship between the electrode electrolyte concentration and the individual values of body fluid electrolyte, the skin potential level (SPL) and reflex (SPR) were measured with 0.06 mol NaCl agar and 0.03 mol KC1 agar as the electrode electrolytes. These electrolyte concentrations were determined in consideration of sodium and potassium concentrations in the palmar tissue. The results showed that under two electrolytes there were no significant differences in relation to SPL and SPR except for the number of SPRs. Therefore, our results support the views on the BSPL mechanism suggested by Christie and Venables (1971 a).

Adult↗
PubMed1979

Estrogen and progesterone receptors in human breast cancer with concomitant assay of plasma 17beta-estradiol, progesterone, and prolactin levels.

The specific estrogen receptor in the cytosol of human breast cancer tissue was assayed in 217 primary cases. The specific progesterone receptor was also assayed in 48 cases as evidence of estrogen action on the tissue. Both receptors were positive in 45.8% of all cases. Plasma 17beta-estradiol and progesterone were assayed concomitantly with these steroid receptors. The higher hormone levels were found in the cases with fewer receptor binding sites. The relationship between 17beta-estradiol levels in tumor cytosol and the number of binding sites was more clearly observed. Plasma prolactin levels, however, showed no correlation with the number of receptor binding sites or the plasma levels of sex steroids. None of these assayed substances had a clear correlation with the histological type of tumor or the clinical stage of the disease.

Binding Sites↗
PubMed1979

[Therapeutic effect of midecamycin on Mycoplasma pneumoniae pneumonia in adults (author's transl)].

The clinical efficacy of a macrolide antibiotic, midecamycin, was studied in 12 adult cases with Mycoplasma pneumoniae pneumonia. The therapeutic effects were excellent or good in 9 cases and fair in 2 cases. On defervescence and disappearance of shadows on chest X-ray the therapeutic effect was satisfactory, but on disappearance of cough therapeutic effect was not clear in some cases. Taking into consideration the antimicrobial activity of midecamycin against Mycoplasma pneumoniae, serum concentration and side effects of midecamycin, this antibiotic is expected to be effective in the treatment of Mycoplasma pneumoniae pneumonia.

Adolescent↗
PubMed1978

Hydrolysis of sugar nucleotides in chicken egg white in response to embryonic development.

The egg white of newly laid chicken egg was found to contain about 45 mumol of UDP-N-acetylgalactosamine 4-sulfate, 34 mumole of GDP-mannose, 6 mumol of UDP-N-acetylhexosamine, and 1 mumol of UDP-N-acetylgalactosamine 4,6-bissulfate per liter. There was no significant difference between infertile and fertile eggs in the initial levels of the sugar nucleotides. During incubation for 4 days, the nucleotide levels in infertile eggs showed little change while those in fertile eggs fell continuously until the complete disappearance of the nucleotides on the fourth day. Initial removal of the blastoderm from fertile eggs resulted in cessation of the reduction in nucleotide levels in the 2- to 4-day period after the operation. The decrease of UDP-N-acetylgalactosamine 4-sulfate was followed by an increase of 1-phospho-N-acetylgalactosamine 4-sulfate then N-acetylgalactosamine 4-sulfate in the egg white. When UDP-N-acetylgalactosamine 4-[35S]sulfate or GDP-[14C]mannose was injected into the egg white of a fertile egg, the main feature of the metabolism of the labeled compounds was the successive hydrolysis of their pyrophosphate and phosphate bonds, with the formation of sugar 1-phosphate and sugar. A significant activity of nucleotide pyrophosphatase was detected in the egg white in newly laid eggs (0-day egg). However, no such activity could be detected in egg-white specimens from 1-, 2-, and 3-day eggs. The results suggest that although the decrease of sugar nucleotides in the first day could be ascribed to the hydrolytic action of the enzyme originally present in the egg white, the decrease in the subsequent 3 days results from a more complex process in which the hydrolysis of the sugar nucleotides is related to the development of the embryo.

Acetylgalactosamine↗