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Biomedical subjects

K Inokuchi

Publications and source records attributed to K Inokuchi.

At least 361 records · Page 20Linked to original sources
PubMed1979

A resected case of pulmonary multiple fibro-leiomyomatous hamartoma--light and electron microscopic study.

A light and electron microscopic study of a case of multiple pulmonary fibro-leiomyomatous hamartoma is described. Like the previous reports, the patient was an old woman with no complaint. The histologic features were characterized by mingling with rich fibroblasts and mesenchymal cells. The definite diagnosis was made by the features which were detected ultrastructurally. In this case, we considered that the fibrous component was more predominant than the leiomyomatous component.

Aged↗
PubMed1979

Histopathological factors predictive for prognosis of lung cancer.

This study was done on 110 lung cancer patients who had received surgical resection consisted of two groups; one group of 43 who survived more than 5 years without recurrence and the other group of 67 who died within one year following surgery. Prognostic significance of the histopathological features at the primary tumor site as well as the regional lymph nodes were compared between the two groups. Blood vessel invasion by the tumor and lymph node metastasis appeared to be equally significant prognostic factors. Patients having the both factors had little chance for survival. Abundant lymphoid cell infiltration around the tumor was associated with longer survival. Lymphoid cell infiltration at the site of blood vessel invasion also was associated with better prognosis. Follicular hyperplasia and paracortical hyperplasia in the regional lymph nodes were favorable prognostic indicators, whereas sinus histocytosis was poorly significant prognostic indicator.

Adenocarcinoma↗
PubMed1979

Flow wave form analysis in vascular surgery.

An analysis of 82 limbs subjected to femoropopliteal bypass grafting demonstrated that electromagnetic flow wave forms of the reconstructed vessel are a reliable indicator in predicting the outcome of surgery. On the basis of this knowledge, postoperative follow-up study of patients who had undergone reconstructive surgery was carried out. Early occult occlusive lesions were detected in 5 of 56 limbs examined, and 3 of these patients underwent successful reoperation with satisfactory restoration of blood flow. Follow-up study using flow wave form analysis is a useful method of detecting occult changes in arteries and leads to early treatment.

Adult↗
PubMed1979

Diagnostic value of percutaneous transhepatic cholangiography judged by personal experience of 58 patients.

During the last seven years percutaneous transhepatic cholangiography (PTC) using a fine needle was performed in 58 patients. The biliary tract was visualised and opacified in the 52 patients with dilated biliary ducts. The correct diagnoses were made in 51 of them. In six patients with a non-dilated biliary system, successful PTC was carried out with the correct diagnoses in four of them. There were four non-fatal complications; two septic reactions, one haemobilia, and one subcapsular haematoma, but all were controlled by conservative treatment alone. The PTC with a fine needle is an accurate, useful and safe procedure of choice for the diagnosis of obstructive jaundice and jaundice of obscure origin. It is useful in distinguishing hepatocellular jaundice from obstructive jaundice thus preventing an unnecessary operation. Failure to visualise the biliary tract by an experienced hand strongly indicates that the jaundice is non-obstructive.

Adult↗
PubMed1979

Treatment of hepatocellular carcinoma with associated cirrhosis.

During the recent 10 years, 105 patients with hepatocellular carcinoma were admitted to our clinic. Seventy of them had an associated cirrhosis of the liver. The therapeutic results of these 70 patients were analyzed according to the mode of treatment. The mean survival periods after admission were as follows; No cancer treatment group (12 patients) 79 days, Chemotherapy group regardless of the mode of administration (25 patients) 97 days, Hepatic artery ligation with chemotherapy group (16 patients) 197 days. Hepatic resection was carried out in 17 patients; partial hepatectomy in 5, left lateral segmentectomy in 1, left lobectomy in 3, and right lobectomy in 8. The 50% survival period of all the hepatectomized patients was 8.5 months. Seven patients are living 5 months to 3 years after operation. Five patients died of recurrence of hepatoma between 4 months and 3 years and 2 months postoperatively. Five individuals died of causes related to the operation; two hepatic failure, two fatal infection, and one massive haemorrhage from acute duodenal ulcer. The results indicated that hepatic resection, from partial to extensive, might be possible even in patients with associated cirrhosis but more exact criteria are mandatory in selecting patients for major hepatic resection. Hepatic artery ligation with chemotherapy should be the first choice for those with nonresectable hepatoma. Continuous infusion of oncolytic agents into the hepatic artery may be considered for those in whom arterial ligation is contraindicated.

Adult↗
PubMed1979

Tumor cell aggregation and mode of cancer spread in linitis plastica type of gastric carcinoma.

Spread of tumor cells in linitis plastica type of gastric carcinoma was studied in relation to features of tumor cell aggregation which were classified into two types: free-cell type and small nest type. Free-cell type was accompanied by a larger amount of fibrous stroma in submucosal layers than in small nest type. In the gastric wall lymphatics and regional lymph nodes, small nest types was more prominent than the free-cell type. Lymphatic permeation was noted predominantly in the submucosa. In the mucosa, both free-cell and small nest types were frequently present. In carcinoma with free-cell type predominance, diffuse infiltration with infrequent lymphogenous spread was noted, while in carcinoma with small nest type predominance, spread via the lymphogenous route was observed more frequently. The mode of cancer spread in this type of carcinoma appeared to be affected by the type of tumor cell aggregation dominant in the mucosa.

Adenocarcinoma, Scirrhous↗
PubMed1979

Sensitive and rapid method for determination of superoxide-generating activity of blood monocytes and its use as a probe for monocyte function in cancer patients.

The superoxide anion-generating capacity of human blood monocytes was measured by a sensitive and rapid method established by taking advantage of the fact that the generation of superoxide anions by monocytes was markedly enhanced by the combined stimulation of the cells with cytochalasin-E and wheat germ agglutinin. The activity was expressed by the initial rate of cytochrome c reduction after the addition of wheat germ agglutinin. The rate obtained with normal human monocytes was 0.73 +/- 0.19 nmol/min/10(5) monocytes (mean +/- SD, n = 10). Because of its sensitivity, the method required only 10(5) monocytes and can be used to follow the monocyte function in various patients. Preliminary data obtained with 15 cases of advanced cancer patients (0.29 +/- 0.10 nmol/min/10(5) monocytes) suggested a possible decrease of the superoxide-generating activity, at least in some state of cancer patients. It appears that measurement of superoxide-generating activity will be meaningful to monitor monocyte function.

Adult↗
PubMed1979

Effect of purified beta glucuronidase infusion in normal dogs and dogs with acidosis.

The effects of systemic infusion of purified beta glucuronidase, lactic acid and a combination of these were studied in normal dogs from the viewpoints of hemodynamics and blood coagulation. In none of the groups was an obvious deterioration in arterial blood pressure, pulse rate, central venous pressure, portal venous pressure and electrocardiogram observed after the infusions. On the other hand, beta glucuronidase infusion with preceding acidosis caused substantial thrombocytopenia accompanied by a decrease in fibrinogen levels and abnormal thromboelastogram. A similar trend was found by the infusion of beta glucuronidase only. An intermediate abnormality was found by the infusion of lactic acid alone. Histologically, fibrin clots in the pulmonary arteries were often observed in the dogs of all groups, but the quantitative difference among the groups was difficult to evaluate. In the present investigation, shock could not be produced, but other data seemed to indicate that increased levels of acid hydrolases in the blood are concerned with deterioration and irreversibility of shock, especially in an acidotic condition.

Acidosis↗
PubMed1979

Enhancing effect of clamping of the portal vein on the effectiveness of antitumor agents against lymph node metastasis.

An experimental study was made on the suppressive effect on lymph node metastasis of an antitumor agent administered during the clamping of the portal vein. When mitomyaneously clamped, a higher concentration of the drug was detected in the mesenteric lymph nodes compared to the conventional intravenous administration. The growth of mesenteric lymph node metastasis was markedly suppressed by the combined use of mitomycin-C and portal vein clamping. These results suggest that the procedure applied in the present study directs a high concentration of antitumor preparations to the lymph nodes in the portal vein region, and thus is a good method for the suppression of lymph node metastasis.

Animals↗
PubMed1979

Deleterious effect of pharmacological doses of corticosteroids after partial hepatectomy in rats.

The aim of the present investigation was to determine whether pharmacological doses of corticosteroid can be used safely in the treatment of haemorrhagic shock during major hepatic resection. Following two-thirds hepatectomy in the rat the administration of dexamethasone, 4 mg/kg of body weight, produced higher morbidity and mortality compared with that in the control groups. This was considered to be mainly due to substantial suppression and retardation of liver regeneration. In addition, the steroid therapy exaggerated the degree and time of liver steatosis with marked elevation of serum fatty acid, triglyceride, phospholipid, and cholesterol concentrations. It appears therefore that it would be very hazardous to treat haemorrhagic shock as a result of major hepatic resection with pharmacological doses of corticosteroids.

Animals↗
PubMed1978

Sequential studies of development of gastric carcinoma in dogs induced by N-methyl-N-nitro-N-nitrosoguanidine.

Fifteen male Beagle dogs received N-methyl-N-nitro-N-nitrosoguanidine (MNNG), 50 or 83 microgram/ml, in drinking water for 35 to 63 weeks. Broad superficial erosion and ulceration were observed in the angulus of the antrum and the anterior or posterior wall of the fundus during MNNG administration. After the discontinuation of MNNG administration, the erosions and ulcers healed rapidly, resulting in mucosal atrophy and scarring of the ulcer. In two dogs new depressions with atypical glands were observed by endoscopy and biopsy of the ulcer scars of the angulus, which became carcinomatous lesions at about the 100th week. Necropsy revealed 5 other carcinomas in the fundus of 5 additional dogs. One lesion was located in the ulcer scar and the other 4 in the areas of the mucosal atrophy. The possible relationship between carcinoma and the associated lesions was discussed.

Animals↗
PubMed1978

A new surgical approach to extensive arterial occlusion of lower extremity--femoro-popliteal open endarterectomy with arteriovenous shunt.

A revascularized surgery for extensive arterial occlusive lesions of the lower extremities, namely open endarterectomy of the occluded femoro-popliteal artery with arteriovenous shunt, was devised. The procedure is specially indicated to the extensive arterial occlusion of the lower extremity for which the conventional reconstructive vascular surgery is not applicable. The patency of the reconstructed femoro-popliteal arteries are ensured by virture of an arteriovenous shunt and newly developed collaterals from the reopened genicular network is expected to provide effective blood flow to peripheral parts. From 1967 to 1975, this procedure was applied to 59 extremities in 53 patients, all of whom had extensive arterial occlusion from the femoral artery to the periphery with impending ulcer and severe rest pain. Fourty-five out of 59 extremities had remarkable improvement of the ischemic symptoms and signs at the time of discharge. Long-term effectiveness was shown in 34 out of 59 extremities or 58 per cent.

Arterial Occlusive Diseases↗
PubMed1978

The preventive effect of cimetidine on producing stress ulcer in rats.

Stress ulcers were formed by a standard method after fasting and restraining each rat in a performed conduit tube and placing them in a cold room head inverted at 4 degrees C for three hours. The severity of the ulcer was graded into four groups; Grade 0: no ulcer, Grade 1: 1-10 ulcers, Grade 2: 11-20 ulcers, Grade 3: more than 21 ulcers. The animals were divided into six groups: Group I: no stress, no treatment; Group II: stressed but not treatment; Group III: pretreated with saline and stressed; Group IV: pretreated with antacid and stressed; Group V: pretreated with Cimetidine and stressed; Group VI: stressed and then post-treated with Cimetidine. In group II 47 out of 49 (96 per cent) developed ulcers compared to no ulcers in group I. In group V, 13 out of 38 (34 per cent) and in group IV, 13 out of 20 (65 per cent) developed ulcers. In group V, not only the incidence was reduced markedly but also the severity of ulcer was significantly less. However, post-treatment with cimetidine was not as effective as pre-treatment. Cimetidine, therefore, seems to be very effective in preventing stress induced ulcers in rat when instilled in the stomach before the stress.

Animals↗
PubMed1978

Platelet aggregability after splenectomy in patients with normosplenism and hypersplenism.

The relationship between platelet count and aggregability was serially evaluated after splenectomy in patients with normosplenism and hypersplenism, and the results were compared with those found in patients undergoing only upper abdominal surgery. The preoperative count and aggregability of platelets were significantly suppressed in patients with cirrhosis of the liver, idiopathic portal hypertension, and prehepatic portal obstruction. However, the platelet aggregability of these patients markedly increased in accordance with the platelet counts after splenectomy. In the patients with normal splenic function preoperatively, splenectomy caused a simultaneous increase in platelet count and aggregability. The platelet function was not always reflected by the count in the patients with idiopathic thrombocytopenic purpura. On the other hand, in the control patients undergoing only laparatomy the platelet count substantially increased two weeks after operation, but platelet aggregability did not differ from the preoperative value. The present results suggest that additional factors for thromboembolism such as hypotension, acidosis, or stagnant blood flow should be avoided during the peak period of reactive thrombocytosis after splenectomy, and that an appropriate use of anticoagulants or inhibitors of platelet aggregation is recommended if and when necessary.

Adenosine Diphosphate↗
PubMed1978

Surgical treatment of renovascular hypertension associated with bilateral renal artery stenosis.

We report on 15 patients operated upon for renovascular hypertension associated with bilateral renal artery stenosis. Followup has been for 1 to 12 years. Four of 5 patients with positive split renal function studies and 3 of 5 patients with positive renal vein renin assays underwent unilateral operations on the positive side. All of these patients were cured or improved. The guide for unilateral operations in hypertensive patients with bilateral renal artery stenosis by angiography was the physiological information obtained from the preoperative screening tests, especially the plasma renin activity ratios of the 3 different veins and the split renal function studies.

Clinical Enzyme Tests↗
PubMed1978

Histochemical investigation of acid mucopolysaccharides in amyloid, colloid and hyaline.

The carbohydrate component in amyloid was histochemically compared with that in colloid or hyaline. Alcian blue, azure A, and periodic acid Schiff were used to stain mucopolysaccharides. In a further attempt to identify various polyanions, staining was carried out with alcian blue containing various concentrations of electrolytes. Methylation, saponification, acid hydrolysis, and digestion with streptomyces or testicular hyaluronidase, or chondroitinase ABC were also employed. The results obtained suggest that the presence of heparitin sulfate in amyloid, of chondroitin sulfate A in hyaline, and of chondroitin sulfate C in colloid.

Amyloid↗