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Biomedical subjects

K Inokuchi

Publications and source records attributed to K Inokuchi.

At least 271 records · Page 15Linked to original sources
PubMed1983

Recurrent gastric carcinoma--analysis of 100 in-patients--.

Between 1964 and 1981, 100 in-patients with recurrent gastric carcinoma following curative resection were investigated in the Second Department of Surgery, Kyushu University Hospital. The disease-free interval after initial operation and the advancement of the carcinoma correlated. The mean disease free interval of cases with local recurrence was 4 years and 1 month, that is 2 years longer than in cases of peritoneal dissemination or hematogenous metastasis. The disease free interval and the survival time after recurrence also correlated. Patients with a relapse more than 2 years after initial operation survived statistically longer than did those with a relapse in less than 2 years (p less than 0.01). One and 2 year survival rates after recurrence in the second resection group was 41.4 per cent and 17.2 per cent, respectively. Almost all patients in the other group died within one year after recurrence. The average survival in patients on a combination of chemotherapy and resection of the recurrent tumor was about 2 years and longer than in cases of resection but without chemotherapy.

Adult↗
PubMed1983

Late results of postoperative long-term cancer chemotherapy for the gastric cancer patients subjected to curative resection.

Postoperative long-term cancer chemotherapy (PLCC) with a combination of Mitomycin-C (MMC), FT-207 and PSK (an immuno-stimulant) was prescribed for gastric cancer patients subjected to curative resection. The 5 year survival rates for patients with stage III and stage IV cancer were 58.3 per cent and 50.0 per cent in the PLCC groups, 48.0 per cent and 15.4 per cent in MMC groups, and 46.3 per cent and 13.3 per cent in no chemotherapy groups, respectively. In stage IV, the survival rate in PLCC group was significantly higher than that in MMC or no chemotherapy group (p less than 0.05). In the PLCC group, there was a tendency toward a dose-dependent effect in each group, and 5 year survival rate of stage III group administered over 60 mg of MMC, 60 g of FT-207 and 270 g of PSK was 70 per cent, such being remarkably higher than 46.3 per cent in those given no chemotherapy (p less than 0.07). There was no drug related death and only a slight leukopenia and hepatotoxicity occurred in some patients.

Antibiotics, Antineoplastic↗
PubMed1983

Small liver cancer.

We report eight cirrhotic patients with liver cancer of less than 2 cm in diameter, and who were successfully treated by surgery. The sensitivities of diagnostic procedures for small lesions showed that alpha-feto-protein (AFP) was 75 per cent, radionuclide scanning 25 per cent, CT 33 per cent, ultrasonography 40 per cent and angiography 88 per cent. Serial measurement of AFP appears to be the most helpful for detection of hepatocellular carcinoma at the early stage, particularly in cirrhotic patients. Although hepatic imagings are of limited value for small hepatic tumors, those tools are often useful as a back-up for the routine tests but not for initial procedures. It should also be kept in mind that hepatic arteriography performed in the high risk group often leads to detection of small cancers. In cirrhotic patients with small hepatocellular carcinoma, surgical resection should be done, providing the clinical status and hepatocellular reserve are adequate.

Carcinoma, Hepatocellular↗
PubMed1983

Cytophotometric DNA analysis of early esophageal carcinoma.

In four patients with early esophageal carcinoma who underwent radical surgery, one died of cancer recurrence 13 months after surgery, two had an uneventful postoperative course after over five years and one succumbed to an incidental pneumonia 18 months postoperatively. Cytophotometric DNA analysis of the cancer cells reflected well the outcome of these patients. One recurrent patient had malignant pattern similar to that seen in usual advanced carcinoma of the esophagus, whereas the remaining three patient without recurrence throughout the postoperative course showed less malignant patterns. These result suggested the potential usefulness of cytophotometric DNA analysis in assessing the prognosis of early esophageal carcinoma.

Carcinoma↗
PubMed1983

Combination chemotherapy enhances survival of patients with unresectable gastric cancer.

Of 177 Japanese patients with a gastric cancer which could not be resected and seen at our institution during the period from 1964 to 1979, 153 were investigated with regard to the efficacy of anticancer agents, in terms of prolongation of life. The average survival time was 23 weeks in the combination chemotherapy group (57 cases), 17 weeks in the single drug chemotherapy group (42 cases) and 13 weeks in no chemotherapy group (54 cases). Three and 6 month survival rates in the overall patients were 57.1 per cent and 16.7 per cent for single drug chemotherapy group, and 37.0 per cent and 11.1 per cent for no chemotherapy group, while in the combination chemotherapy group, the rates were higher at 64.9 per cent and 29.8 per cent, respectively (combination chemotherapy vs. no chemotherapy group, p less than 0.05). In patients with peritoneal dissemination, hepatic metastasis and carcinomatous ascites, there was a significant difference in survival rates between those prescribed combination chemotherapy and those given no chemotherapy (p less than 0.05). Of 57 in the combination chemotherapy group, 6 and 9 month survival rates were 45.5 per cent and 22.7 per cent in the postoperative long-term cancer chemotherapy (PLCC) group (22 cases), such being higher than other combination chemotherapy group (35 cases), 22.9 per cent and 11.4 per cent, respectively. There was a significant difference in the survival rates between the two groups (p less than 0.05).

Adult↗
PubMed1983

Inhibitory effect of cimetidine on liver regeneration after two-thirds hepatectomy in rats.

The effects of cimetidine on the regenerating liver were studied in rats after they had two-thirds hepatectomy. In Group I, standard two-thirds hepatectomy was performed. In Group II, cimetidine in a dose of 40 mg/kg was given intramuscularly immediately and 24 and 48 hours after two-thirds hepatectomy. In Group III, the same amount of cimetidine was given after a sham operation. Mortality rate, liver weight restoration, mitotic activities of remnant livers, and serum levels of aminotransferases and albumin were examined from 24 hours to 14 days after operation. The mortality rate was 11.1 percent in Group II, whereas no rats in Groups I and III died. Although there were no differences in the residual liver weights among the hepatectomized groups, treatment with cimetidine induced substantial suppression and delay of liver cell division. The serum aminotransferase levels in Group II increased significantly after hepatectomy compared with the levels in Group I. The albumin synthesis remained suppressed in Group II. Light microscopy showed prolonged liver steatosis and marked dilatation of the sinusoidal space in that group. Our results may indicate that cimetidine has an inhibitory effect on liver regeneration and that it should be administered very carefully after extensive hepatic resection if applied as prophylaxis for the life-threatening complication, stress ulcer syndrome. Otherwise, antacid therapy or other trials should be carried out.

Animals↗
PubMed1983

Mutation causing overproduction of outer membrane protein OmpF and suppression of OmpC synthesis in Escherichia coli.

A novel mutation affecting the synthesis of major outer membrane proteins OmpF and OmpC in Escherichia coli K-12 is described. The mutation resulted in overproduction of the OmpF protein with concomitant suppression of OmpC synthesis. This mutation, designated as ompFp100, was mapped at 21 min on the E. coli chromosome map with the gene order aroA-aspC-ompF4-ompFp100-asnS-pyrD. This mutation was cis-dominant to the expression of the ompF gene. In addition, the direction of the mRNA transcription of the ompF gene was from asnS to aspC. These results strongly indicate that ompFp100 is a promoter mutation of the ompF gene. Introduction of an ompF mutation, which causes the disappearance of the OmpF protein, into strains carrying the ompFp100 mutation resulted in the reappearance of the OmpC protein in the outer membrane. Addition of a high concentration of sucrose to the medium, which suppresses the OmpF synthesis and stimulates the OmpC synthesis in the wild-type strain, resulted in the reappearance of the OmpC protein in the ompFp100 mutant with concomitant suppression of the overproduction of the OmpF protein. These results suggest that suppression of OmpC synthesis in the ompFp100 mutant is due to overproduction of the OmpF protein.

Bacterial Outer Membrane Proteins↗
PubMed1983

[Effect of adjuvant immunotherapy with Nocardia rubra cell-wall skeleton in lung cancer].

A randomized clinical trial of intrapleural Nocardia rubra cell-wall skeleton (N-CWS) followed by intradermal N-CWS was performed against lung cancer patients from November, 1977 to June 1981. Totally, 190 patients were entered into this trial. The N-CWS treatment was effective in terms of prolongation of remission duration against not only operable but also inoperable patients. However, significant improvement of survival rate was observed only in operable patients, especially curative+relatively curative resection-group (p less than 0.05). The mode of recurrence was classified as local recurrence and distant metastasis in the curative+relatively curative resection-group. The rates of distant metastasis were 34.1 and 17.6%, respectively, in the control and the N-CWS groups. The rate of local recurrence was 13.6% in the control group, however, no local recurrence was observed in the C-NWS group. These results indicate the clinical effectiveness of the N-CWS treatment especially in curatively resectable lung cancer. No serious side effect was experienced during this trial.

Adenocarcinoma↗
PubMed1983

[Treatment of liver cancer and concomitant esophageal varices].

We have treated 123 cirrhotic patients having liver cancer associated with esophageal varices. Among these patients, 10 underwent hepatic resection together with variceal surgeries simultaneously. These procedures were feasible when the liver tumor was detected in an early stage, and hepatocellular function was preserved as much as major hepatic resection was acceptable. One, 2 and 5 year survival rates were 73.4%, 58.7% and 29.4%, respectively. In 5 patients with non-resectable hepatoma, variceal surgery was done, but 4 died of hematemesis finally. The result is suggestive that variceal surgery in such patients appears to be ineffective. Recently, endoscopic sclerotherapy had been performed for variceal bleeding in poor risk patients. Lipiodol, contrast material, has been attempted to use for chemotherapy for advanced hepatocellular carcinoma, making use of the characteristic of the oli that this material remains selectively in the tumor for a long time when it is administered through the artery feeding the tumor. We have used this mode of therapy and prominent decrease of alpha-fetoprotein has been evident in 5 patients with non-resectable hepatoma until the present time. These less invasive methods are considered to be treatment of choice in patients with advanced liver cancer and concomitant esophageal varices.

Animals↗
PubMed1983

[Evaluation of postoperative longterm chemotherapy against gastric cancer].

The combination of surgery with chemotherapy is mandatory to get a higher survival rate in gastric cancer. A study on adjuvant chemotherapy must be conducted in a setting of controlled trial and include a sufficient number of cases to yield statistically significant evaluation. The Cooperative Study Group of Surgical Adjuvant Chemotherapy for Gastric Cancer in Japan including 297 hospitals initiated its operation in 1975. The first study with cases revealed that the protocol consisting bolus intravenous injection of MMC plus oral administration of Futraful for 3 months was effective in improving 5-year survival of gastric cancer patients with stages III and IV and, for those with a positive metastasis into the lymph nodes, with obvious serosal invasion (n(+)ps. (+). This cooperative study group has been expanded in a form of The Japanese Foundation of Multi-disciplinary Treatment of Cancer in 1980. The study on efficacy of adjuvant immunochemotherapy for gastric cancer is on-going.

Antineoplastic Agents↗
PubMed1983

[Adjuvant chemotherapy for aged patients with gastric carcinoma].

The effectiveness of postoperative adjuvant chemotherapy on aged patients (more than 70 years old) with resectable gastric carcinoma was examined in our Department. Of the 178 patients, 75 patients received the drugs on various regimen and 103 patients had no chemotherapy a control group). No significant difference was noted in patient characteristics of age, sex and curability. In advanced gastric carcinoma such as stage III and IV, a significant increase in long-term survival after surgery was obtained with combination chemotherapy or immunochemotherapy compared with the control group (P less than 0.05). On the other hand, there was no significant difference in a survival rate of the patients with stage I and II.

Aged↗
PubMed1983

[Randomized study on the long-term adjuvant chemotherapy with ftorafur and mitomycin C for stomach cancer: second report].

In view of the usefulness of long-term adjuvant chemotherapy, the Cooperative Study Group of Surgical Adjuvant Chemotherapy for Gastric Cancer adopted as the second cooperative study a prospective randomized trial on three groups; MMC alone, Futraful alone and a combination of MMC and Futraful. In the group of Futraful alone the survival and disease-free rate were improved in three years after operation, especially marked in patients with the advanced stage. Moreover, the survival and disease-free rate in the group of the combination therapy were higher than those in the group of Futraful alone, and the relapse rate was lower in the former. Therefore, a long-term combined adjuvant chemotherapy with MMC and Futraful seems to be one of the most effective chemotherapy regimens for resectable advanced gastric cancer.

Drug Therapy, Combination↗
PubMed1983

Delayed anastomosis of the cervical portion of the esophagus in bypass operations for unresectable carcinoma of the esophagus.

To prevent the high incidence of anastomotic leakage in a bypass operation for unresectable carcinoma of the esophagus, we devised a two stage bypass procedure, in which the anastomosis of the cervical portion of the esophagus to the gastric tube is delayed for about two weeks after the first operation. With this approach, the short segment of the cervical part of the esophagus adequately adheres to the surrounding tissue by the time of the second operation, and the anastomotic site no longer responds to the strong force accompanying deglutition. One-half of the anastomotic leaks which occurred on the one stage procedure was reduced to nil when the two stage approach was done.

Esophageal Neoplasms↗
PubMed1983

Antibody specific for lung cancer cells detected in sera of patients with bronchogenic carcinoma.

Two hundred and seventy-one sera from patients with lung cancer were checked to determine whether they exerted a blocking or potentiating effect on normal lymphocyte-cytotoxicity against lung cancer targets using a microcytotoxicity assay. A blocking effect was observed in 15 of 49 untreated patients (30.6%), but a potentiating effect was detected in 10 of 49 (20.4%). Such effects were not correlated with stages of the disease or the clinical status of patients. Such a blocking effect was also detected in patients with pneumonia, pulmonary tuberculosis, benign mediastinal tumor and malignancies other than lung cancer, but the potentiating effect could not detected in such patients. Using an indirect membrane immunofluorescence test, IgG antibodies against QG-56 of a lung cancer cell line were detected in 54.3% of potentiating sera and in 20.5% of blocking sera. Such antibodies were cross-reactive with 2 other lung cancer cell lines and one of 4 uterine cancer lines, however, no cross-reaction was observed against 3 breast cancer lines, 3 of 4 uterine cancer lines, one malignant melanoma line and one pancreas cancer line. The effector cells exerting the potentiating effect were identified as non-adherent, Fc receptor-bearing lymphocytes. Therefore, the potentiating effect might be typical antibody-dependent cell-mediated cytotoxicity.

Antibodies, Neoplasm↗
PubMed1983

Endotract antenna for application of hyperthermia to malignant lesions.

As hyperthermia treatment for deeply located malignant lesions is most difficult, two types of endotract antenna were devised, one constructed for radio frequency and the other for administration of microwave to tumors of the esophagus and colorectum. Well-controlled temperatures can be applied to the narrowed pyloric canal of dogs with these two instruments, which appear to have great promise for clinical application.

Animals↗
PubMed1983

Patterns of recurrence after curative resection for carcinoma of the thoracic part of the esophagus.

Two hundred patients with a previously untreated carcinoma of the thoracic portion of the esophagus and who underwent curative or noncurative resection were retrospectively evaluated. The patterns of recurrence were compared with the pathologic findings at operation. In 30 of 90 (33.3 per cent) patients in the curative resection group and 68 of 110 (61.8 per cent) of those in the noncurative resection group, there was a recurrence. Hematogenic recurrence was most frequent in instances of blood vessel invasion of the carcinoma detected at the time of the operation, and death occurred during the early postoperative period. Lymph node recurrence was most frequent in instances of lymphatic invasion or blood vessel invasion, or both, and the postoperative survival time in such patients was double that seen in those with a hematogenic-related recurrence.

Adult↗
PubMed1983

[Significance of splenectomy in the treatment of cancer].

With inoculation of a large amount of tumor cells, the tumor growth of splenectomized mice was depressed compared to sham operated mice. On the contrary, with inoculation of a small amount of tumor cells the occurrence of tumor was lower in sham-operated mice. The effect of splenectomy on tumor growth was bidirectional depending on the dose of the inoculate. The effect was due to the production of the immunosuppressive factor in sera obtained from mice inoculated with a large but not small amount of tumor cells. Studies for the late survivals of 113 patients who had received curative total gastrectomy with or without splenectomy revealed that the non-splenectomized group showed a significantly better late survival rate than the splenectomized group when the splenic hilar lymph nodes were not involved with cancer metastasis.

Animals↗