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K Inagawa

Publications and source records attributed to K Inagawa.

27 records · Page 2Linked to original sources
PubMed1996

Free medial thigh perforator-based flaps: new definition of the pedicle vessels and versatile application.

The medial thigh flap is a perforator-based flap nourished with septocutaneous or muscle perforators originating from the femoral vessels. To date, 8 patients have been repaired with this flap and extended or connected flaps including this flap: 4 patients with lower leg defects and 4 patients with intraoral and neck defects. The advantages of this flap are (1) several pedicle perforators exist for this flap, which makes possible duplicated vascular anastomoses to establish reliable circulation of the transferred flap; (2) the flap can be extended or connected to other neighboring flaps in the anterior thigh, so that extensively wide defects can be closed in one stage; (3) the great saphenous vein can be simultaneously used as a vein graft or for venous drainage for the flap; (4) the anterior branch of the femoral nerve can be used for sensory potential; and (5) there is minimum morbidity of the donor defect and a large dominant vessel for the leg can be preserved. The suitable indications for this flap are defects after removal of skin cancer in the foot or lower leg and wide defects after resection of head and neck cancer, which can be reconstructed with the flap connected to neighboring skin flaps. The disadvantages of this flap are that it has a small, short vascular pedicle and the bulkiness of the flap's fatty tissue often requires thinning.

Aged↗
PubMed1995

Pharmacological profile of (-)HT-90B, a novel 5-HT1A receptor agonist/5-HT2 receptor antagonist.

1. HT-90B ((-)-N-([2-(8-methyl-l, 4-benzodioxane-2-ylmethyl)amino]ethyl) tricyclo[3,3,1,1(3.7)] decane-1-carboxamide) had high affinities for the 5-HT1A (Ki = 0.18 nM) and 5-HT2 (Ki = 9.2 nM) receptors. 2. HT-90B inhibited forskolin activated adenylate cyclase in rat hippocampal membranes as a 5-HT1A full agonist (IC50 = 2 nM), and the potency of the drug was higher than that of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), a standard 5-HT1A agonist. 3. In the serotonin syndrome test, HT-90B behaved as a weak partial 5-HT1A agonist in reserpinized rats. 4. 5-HT2 receptor-mediated potentiation of rabbit platelet aggregation by serotonin (5-HT) was reduced by HT-90B (IC50 = 1.73 microM). 5. Head twitch response induced by 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), a 5-HT2 agonist, was inhibited by HT-90B in mice. 6. It is concluded that HT-90B has potent 5-HT1A receptor agonist as well as 5-HT2 receptor antagonist properties in vitro and in vivo.

8-Hydroxy-2-(di-n-propylamino)tetralin↗
PubMed1994

Impairment of spatial working memory of rats in radial maze performance induced by ethylcholine mustard aziridinium picrylsulfonate (AF64A-P): retention curve analysis.

The effects of the cholinergic neurotoxin, ethylcholine mustard aziridinium picrylsulfonate (AF64A-P), on the spatial working memory in eight-arm radial maze performance were studied. Rats well-trained on radial maze performance were injected intracerebroventricularly with AF64A-P (0.05 nmol/each side) or artificial cerebrospinal fluid (A-CSF, 5 microliters). AF64A-P produced a selective reduction of choline acetyltransferase activity in the hippocampus. Rats treated with AF64A-P showed a significant decrease in the number of correct responses in baseline performance compared to rats injected with A-CSF. To examine whether the deficits might result from the disruption of memory, tests of memory retention were studied. Various delay intervals (45, 90, 180, or 360 min) were interposed between the fourth and the fifth choice, and the number of correct responses in the choices 5-8 were then examined as a function of retention intervals. Significant interaction of deficits in arm-choice accuracy induced by AF64A-P with retention intervals in the choices 5-8 was observed. Oxotremorine, a muscarinic receptor agonist (0.025, 0.05 and 0.1 mg/kg, ip), was able to reverse this deficit in a dose-dependent manner. These observations reveal a pattern of impairment of spatial working memory during prolonged states of central cholinergic hypofunction induced by intracerebroventricular administration of AF64A-P, which binds irreversibly to its receptor site.

Animals↗
PubMed1993

Cholinergic modulation of spatial working memory of mice in radial maze performance: retention curve analysis.

Cholinergic modulation of the spatial working memory of mice was investigated in an eight-arm radial maze. The mice were trained to achieve a stable baseline level of performance, and the retention of spatial working memory was then examined by means of imposition of retention intervals of 45, 90, 180, and 360 min between choices four and five. The animals were removed from the apparatus during these intervals. The effects of oxotremorine (0.025-0.1 mg/kg, ip), physostigmine (0.025-0.1 mg/kg, ip), and scopolamine (0.1-0.4 mg/kg, ip) on the number of the correct responses after the various time intervals (5-8 choices) were studied. Mice received drug injections 30 min prior to the first four arm-choices before delay intervals (1-4 choices). The number of correct responses after the intervals decreased with the increased length of the retention interval. Oxotremorine and physostigmine exhibited dose-dependent stimulating effects of resistance to decreases in the number of correct responses, but scopolamine potentiated the decline in a dose-dependent manner. Significant interactions between the effects of cholinergic drugs and the length of retention over time were also observed. These observations indicate a cholinergic modulation of spatial working memory in mice engaged in radial maze performance, as assessed by means of retention curve analysis.

Animals↗
PubMed1992

[Discriminative stimulus properties of D-amphetamine: a neuropharmacological review].

It has been reported that laboratory animals can discriminate the presence of the psychomotor stimulant, D-amphetamine, from a non-drug or another drug condition. Under test conditions, doses lower than the training dose typically result in proportional decreases in D-amphetamine-appropriate responding, that is, dose-response curve is obtained. When drugs other than the training drug (D-amphetamine) are tested, they produced drug-appropriate responding to the extent that they resemble D-amphetamine (generalization or substitution test). And some antagonists (e.g., chlorpromazine) attenuate the stimulus effects of training drug. In the present review, the attempt to characterize the neuropharmacological characteristics of the discriminative stimulus properties of D-amphetamine is presented. The neural processes due to the transduction of D-amphetamine into stimulus properties may primarily involve central dopaminergic nervous system. Furthermore, drugs that share the discriminative stimulus properties in laboratory animals often produce similar subjective effects in human.

Animals↗
PubMed1991

Effects of diazepam and chlorpromazine on socially induced anxiety in pigeons.

The effects of diazepam and chlorpromazine on response suppression in a social situation were studied in pigeons. Three groups of pigeons were trained to peck a key on a variable-interval 60-s schedule of reinforcement, then exposed to the pain reaction of adjoining pigeon to electric shock. Although every pigeon showed suppression of response, the suppression decreased with repeated exposures. A conditioning group received the electric shock with the exposure to the pain reaction of adjoining bird; a shock exposure group received the electric shock without any explicit conditioned stimulus; and a control group did not receive any shock. After these treatments every group was exposed to the pain reaction of the adjoining bird. The conditioning group and the shock exposure group showed clear response suppression, but the control group did not. Although chlorpromazine generally reduced response rate in all groups, diazepam selectively abolished the response suppression.

Animals↗
PubMed1988

The role of myelination in learning performance observed in two strains of myelin-deficient mutant mice (shiverer and mld).

In order to study whether myelination is involved in learning performance, the behavior of myelin-deficient mutant mice (shiverer and mld) was examined. Shiverer is a deletion mutant of the myelin basic protein (MBP) gene causing severe myelin deficits due to the complete absence of MBP, while mld, allelic mutant to shiverer, shows lowered MBP expression, resulting in less severe effects. Shiverer clearly showed deficits in successive reversal learning, while mld showed less deficits in the learning performance. Both mutant mice showed no deficits in the radial maze performance, which is though to show the natural foraging behavior of rodents. These results suggest that myelin formation is related to learning but not to natural behavior.

Animals↗
PubMedDate not supplied

Application of the RealAudio package to computerized medical lectures.

We created a multimedia system to computerize past lectures using RealAudio software. Physicians, medical researchers and students can browse the contents of lecture slides and handouts with synchronous audio using the Internet. The audience can easily review the most interesting parts of lectures and medical students can listen to complete medical lectures from remote sites with narration and slide depiction, whenever convenient. We have created three multimedia programs; the memorial lecture of a professor's retirement, a new method of hand washing for surgical procedures and a lecture on medical informatics. The cost of this system and the results of the evaluation by medical students are described. The ease of using this application makes it a potentially valuable tool for clinicians and researchers.

Computer-Assisted Instruction↗