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Biomedical subjects

K Inagaki

Publications and source records attributed to K Inagaki.

214 records · Page 12Linked to original sources
PubMedDate not supplied

Young children's naive theory of biology.

This article aimed at investigating the nature of young children's naive theory of biology by reviewing a large number of studies conducted in our laboratories. More specifically, we tried to answer the following five critical questions. What components does young children's knowledge system for biological phenomena (or naive biology) have? What functions does it have in children's lives? How is it acquired in ontogenesis? How does its early version change as children grow older? Is it universal across cultures and through history? We propose that young children's biological knowledge system has at least three components, that is, knowledge needed to specify the target objects of biology, ways of inferring attributes or behaviors of biological kinds, and a non-intentional causal explanatory framework, and that these three constitute a form of biology, which is adaptive in children's lives. We also claim that the core of naive biology is acquired based on specific cognitive constraints as well as the general mechanism of personification and the resultant vitalistic causality, but it is differently instantiated and elaborated through activity-based experiences in the surrounding culture.

Biology↗
PubMedDate not supplied

Basic studies on a new material for inducing antitumor immune cells.

Recently, adoptive immunotherapy for cancer with lymphokine activated killer (LAK) cells has been widely used experimentally. The therapy has several problems, including difficulty in handling, sterilization, and time consumption. To solve these problems, new materials able to induce antitumor immune cells were investigated. Pokeweed mitogen (PWM) and PWM-conjugated materials (CMC-1) could induce strong killer cells by short-term stimulation of human peripheral blood lymphocytes (PBL). The induced killer cells showed a wide killing spectrum in vitro against human tumor cell lines (MKK-1, PRMI4788, NBT-2, ZR-7530, H-1, Hela, KB, HMV-1, PC-10, C-1). Human PBL stimulated for a short time by CMC-1 also showed a tumoricidal effect on tumor bearing (MKN-1, MKN-45) nude mice. These results suggest that CMC-1 may solve the problems with currently used LAK therapy and may provide easily applicable extracorporeal immunotherapy for cancer.

Cell Line↗
PubMedDate not supplied

Chemical compatibility of cefmetazole sodium with ranitidine hydrochloride during simulated Y-site administration.

The stability of cefmetazole sodium and ranitidine hydrochloride was studied under conditions simulating administration via a Y-injection site into a primary infusion line. Cefmetazole sodium was reconstituted with both 0.9% sodium chloride injection (50 mL or 100 mL) and 5% dextrose injection (50 mL) to produce premixing concentrations of cefmetazole 10 and 20 mg/mL. Ranitidine hydrochloride injection was diluted with 50 mL 0.9% sodium chloride injection to give premixing concentrations of ranitidine 1 mg/mL. To simulate Y-site administration, 2 mL of cefmetazole was mixed with 2 mL of ranitidine in a 10-mL glass test tube. All study mixtures were prepared in triplicate and stored at room temperature (22-23 degrees C) under normal fluorescent room lighting. Samples of these admixtures were inspected for visual changes and tested for pH. The concentrations of two drugs were immediately determined by stability-indicating high-performance liquid chromatographic assay methods after mixing and at 1, 2, and 4 hours. No visual changes were observed. The pH in the admixtures was influenced by concentrations of the two drugs. The pH of each single-drug solution did not change during the study period. On the other hand, the pH of any admixtures of cefmetazole and ranitidine solutions prepared with 0.9% sodium chloride or 5% dextrose injection, decreased. Cefmetazole in any of the admixtures with ranitidine retained greater than 95% of its original concentration for 4 hours.(ABSTRACT TRUNCATED AT 250 WORDS)

Cefmetazole↗