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Biomedical subjects

K Imaoka

Publications and source records attributed to K Imaoka.

52 records · Page 3Linked to original sources
PubMed1986

Mouse strain difference in bile duct lesions induced by swine serum injections.

The mouse strain difference in bile duct lesions was studied on male A/J, BALB/c, C57BL/6, C3H/He, DBA/2 and DDY mice 4 weeks old given intraperitoneal injections of swine serum (0.05 or 0.2 ml per mouse) twice a week for 4 weeks. The hepatic lesions were restricted to the portal tract. Biliary epithelial cells showed hypertrophy and hyperplasia, and eosinophilic and homogeneous or needle-shaped material appeared in the cytoplasm of such hypertrophied epithelial cells and in the ductular lumen. Around these damaged biliary epithelia, eosinophil leukocyte and plasma cell infiltration with proliferation of collagen fibres was commonly detected. These changes became more apparent with increasing size of bile duct. Such histopathological characteristics of hepatic lesions were essentially the same in all strains, but the severity showed a clear strain difference: the lesion was marked in the DDY, A/J and BALB/c strains, moderate in C3H/He and slight in C57BL/6 and DBA/2. A high production of anti-swine-serum antibodies associated with a marked increase in the number of mouse IgG-producing lymphocytes in the spleen was detected in the strains showing the marked hepatic lesions.

Animals↗
PubMed1986

Development of spontaneous tongue calcification and polypoid lesions in DBA/2NCrj mice.

Calcified tongue lesions were observed in 4- to 8-week-old DBA/2NCrj mice, the highest frequency being reached at 6 weeks of age. Calcification was initially observed in the superficial longitudinal muscles and these lesions were distributed segmentally under the dorsolateral mucous epithelium in the middle portion of the lingual body. After calcification, marked inflammation was observed in the same lesion. Finally, the swollen tissue elevated the covering mucous epithelium and produced polypoid lesions.

Animals↗
PubMed1985

R-R intervals of ECG in depression.

ECG measurements of consecutive 100 R-R intervals were done on depressive patients. The patient group presented lower mean values for coefficients of variation (CV) at each generation than the control group (normal subjects); the differences were significant especially for the subjects 40 to 49 years of age (P less than 0.05) and for those 60 to 69 years of age (P less than 0.01). These results can probably be regarded as a significant and objective index of autonomic disturbances in depression.

Adult↗
PubMed1980

Simultaneous measurements of shifts of the center of gravity caused by ventilation and cardiac motions towards three body axes.

A method is described for the simultaneous measurements of three dimensional shifts of the gravitational center of the body caused by ventilatory and cardiac motions. The measuring system consists fundamentally of three load cells which support an aluminum die-casting platform. Measurement of the shift towards the X axis (front-to-back) was achieved by double integration of the outputs of load cells in order to convert acceleration into a shift of gravity. The records of a volunteer subjects measured with ECG and ventilatory flow showed two cardinal oscillations; one coinciding with the heat rate and the other with the ventilatory frequency. This became clear when recorded through either a low-pass or high-pass filter. Animal who breathed a SF6-O2 mixture into one side of the lungs or those with partial occlusion of a bronchus showed distinct changes in the pattern of the Y axis (right-to-left). These preliminary experiments convinced us that the system can serve as a non-invasive monitoring system of cardiopulmonary functions.

Animals↗