Biomedical subjects

K Iimori

Publications and source records attributed to K Iimori.

30 records · Page 2Linked to original sources

PubMed1982

Influence of feeding situation on stomach ulcers and organ weights in rats in the activity-stress ulcer paradigm.

Rats housed in running wheel activity cages except for 1 hr each day, during which time they were fed in their home cages, revealed more stomach ulceration, a higher level of brain MHPG-SO4, and larger weight changes in the thymus, spleen and adrenal gland, compared to rats housed in running-wheel activity cages and fed 1 hr daily in those same cages. Rats in the latter group showed more stress pathology than did control rats which were housed in standard home cages but which received the same restricted (1 hr per day) feeding schedule. These results did not support the idea that excessive running might occur in response to certain motivational states (e.g., frustration due to restricted feeding). The data suggested that feeding activity-stress rats in their home cages might aggravate the development of stomach ulcers coincident with the organ weight changes and the enhancement of noradrenaline turnover in the brain.

Adrenal Glands↗

PubMed1982

Priming effects of activity-stress ulcer in rats.

The activity-stress ulcer procedure consists of housing rats in running-wheel activity cages while at the same time, restricting their food intake to 1 hr per day. Male Wistar rats which had been habituated with ad lib feeding to the running-wheel cage environment for 3 days prior to the restricted feeding phase, developed significantly more gastric glandular ulcers and exhibited greater levels of running activity when compared to rats which had been given no habituation experience. Control rats housed in standard laboratory cages but which received the same restricted feeding regimen, developed significantly less stress pathology. Since allowing to rats access to the running-wheel during habituation resulted in enhanced stress pathology, this manipulation is referred to as a "priming effect." A possible explanation for such a "priming effect" is discussed in terms of procedures which may increase running wheel activity and decreases survival time during the restricted feeding phase of the activity-stress ulcer procedure.

Animals↗

PubMed1982

Psychological stress enhances noradrenaline turnover in specific brain regions in rats.

Concentrations of noradrenaline (NA) and 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO4) in the hypothalamus, amygdala, cerebral cortex and pons + medulla oblongata were examined in male Wistar rats exposed to foot-shock or to psychological stress for 1 hour. Animals in the psychological stress group were prevented from receiving foot shock, but were exposed to responses of shocked rats. Foot shocked rats exhibited a significant reduction in NA content and a significant elevation in MHPG-SO4 level in all brain regions when compared to control rats which were neither shocked nor exposed to shocked rats. Rats exposed to the psychological stress displayed a significant reduction of NA level in the amygdala, significant elevation of MHPG-SO4 content in the hypothalamus and amygdala, and a moderate elevation of plasma corticosterone level. These results suggest that psychological stress produces mild enhancement of NA release preferentially in the hypothalamus and amygdala; while foot shock stress elicits a more intense response of noradrenergic neurons in more extended brain regions.

Amygdala↗

PubMed1982

Effects of age and stress on regional noradrenaline metabolism in the rat brain.

Levels of noradrenaline (NA) and its major metabolite, 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO4), were determined in eight brain regions of non-stressed rats at 2, 10 and 15 months of age, and of rats at 2 and 15 months of age stressed by immobilization for 3 hours. The NA levels in older rats were significantly lower in the hypothalamus, pons + med.obl. and midbrain, and higher in the amygdala, thalamus, hippocampus and cerebral cortex as compared to those of 2 month old rats. The MHPG-SO4 levels in the older rats were significantly lower in the hypothalamus, amygdala, pons + med.obl. and midbrain, and higher only in the cerebral cortex than those in 2 month old rats. Immobilization stress caused significant increases in NA turnover in all brain regions of both 2 and 15 month old rats. Age-related difference in the degree of stress-induced change in NA metabolism was found only in the hypothalamus; the increase of MHPG-SO4 by stress was greater in 2 month old rats than in 15 month old rats, although both age groups of rats showed the same degree of NA reduction by stress. These data suggest that brain NA metabolism changes in an age-related fashion, and that apparent regional differences exist in the pattern of these changes. Specifically, it appears that there is an age-related difference in the response of noradrenergic neurons to stress in the hypothalamus.

Aging↗

PubMed1982

Postnatal development of noradrenaline and 3-methoxy-4-hydroxyphenylethyleneglycol sulphate levels in rat brain regions.

Developmental changes in brain levels of noradrenaline (NA) and 3-methoxy-4-hydroxyphenylethyleneglycol sulphate (MHPG-SO4) were studied in rats. In most brain regions, MHPG-SO4 level rapidly increased to approach or exceed adult levels at the time of weaning, while NA levels increased more gradually and reached adult levels following weaning. Pharmacological studies showed that the MHPG-SO4 level in the neonatal brain reflects the degradation of released NA. The developmental characteristics of noradrenergic neurons in eight discrete brain regions are discussed.

Aging↗

PubMed1982