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Biomedical subjects

K Iguchi

Publications and source records attributed to K Iguchi.

At least 109 records · Page 6Linked to original sources
PubMed1988

[Experiences with sultamicillin granules in pediatric patients].

Sultamicillin (SBTPC) is a combination drug of sulbactam (SBT) and ampicillin (ABPC) in an ester bonding at 1:1 ratio. SBT, a new semisynthetic beta-lactamase inhibitor restores and extends the spectrum of ABPC against resistant strains of bacteria. SBTPC granules were administered to 26 pediatric patients with infections, and clinical efficacies were studied in 23 patients. The clinical efficacy rate was 95.7% and the drug was evaluated to be highly effective for the treatment of infectious diseases in the pediatric field. SBTPC was safe and well tolerated.

Age Factors↗
PubMed1987

Antiproliferative and cytotoxic effects of newly discovered halogenated coral prostanoids from the Japanese stolonifer Clavularia viridis on human myeloid leukemia cells in culture.

The antiproliferative and cytotoxic activities of newly discovered halogenated coral prostanoids (chlorovulone, bromovulone, and iodovulone) from the Japanese stolonifer Clavularia viridis and their related compounds were determined in HL-60 cells in culture. The order of antiproliferative and cytotoxic activities of naturally occurring marine prostanoids against HL-60 cells was chlorovulone I greater than bromovulone I = iodovulone I greater than clavulone I or II greater than prostaglandin A2. The IC50 (concentrations required to inhibit cell growth by 50%) value (0.03 microM (0.01 microgram/ml)) and cytotoxic effects (greater than 0.3 microM (0.1 microgram/ml)) of chlorovulone I were about 200 and 100 times stronger than those of prostaglandin A2, respectively, on the molar basis. From our data on the structure-activity relationship of the halogenated coral prostanoids and the related compounds, we elucidated that 1) the alkylidencyclopentenone structure in these prostanoids was essential for the antiproliferative and cytotoxic activities against HL-60 cells and the introduction of halogen function at C-10 position in the structure enhanced the activities (C1 = F greater than Br = I greater than H); 2) the stereospecificity of the 12-hydroxyl group in the chlorovulone molecule was not required for the activities; 3) the presence of dienone (C5-6 and C7-8) in the structure potentiated the activities. Bivariate DNA/bromodeoxyuridine analysis with a flow cytometer showed that chlorovulone I transiently arrested the cell cycle progression from G1 to S after 24-hr exposure to the nontoxic concentrations (0.03 and 0.09 microM) and caused the lasting blockade of leukemia cells in G1 at the cytotoxic concentration. These results suggest that these coral prostanoids and related compounds may be a promising antileukemic agent.

Animals↗
PubMed1987

Plasma histamine levels in normal and atopic children.

Plasma histamine was measured in 258 children by using a sensitive high performance liquid chromatographic method. A normal level of histamine, which was high at a lower age and low at a higher age, was determined. Atopic children had higher levels than normal children. The extent of atopic disease had a relationship with higher levels. The correlations between plasma histamine and basophil count and between plasma histamine and IgE were significant in atopic children but not in normal children.

Adolescent↗
PubMed1986

[Clinico-pathological study of thyroid carcinomas detected by mass screening].

Ultrasound examination is a useful diagnostic procedure in mass screening for thyroid tumors. Between September 1983 and September 1985, we found many cases of nodular lesions in the thyroid, in which we frequently detected small carcinomas by echo-guided aspiration cytology. Nineteen thousand eight hundred twenty-four samples were examined, and echo-guided aspiration cytology was carried out in 1,169 persons, from which 115 positive cases were obtained. Seventy-four patients were operated upon, and 71 of them (96%) were found to have carcinomas, including 40 cases of small papillary carcinomas less than 10 mm in largest diameter. These small carcinomas were classified into four types histologically. Echogram patterns were different from each other and corresponded to histological types. Cytological figures of the small papillary carcinomas were also varied.

Adult↗