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Biomedical subjects

K Iga

Publications and source records attributed to K Iga.

96 records · Page 6Linked to original sources
PubMed1978

Dissolution profiles of drugs from tablets.

A theoretical equation to describe the drug dissolution from a tablet was derived by combining and equation for the disintegration rate of a tablet with an equation for the dissolution of particles. The theory is based on the assumptions that: (a) dissolution occurs only from the particles released in a medium by tablet disintegration, (b) the number of particles released into a medium obeys the equation N = NO(T/Td)m, and (c) the dissolution of particles, which are spherical in shape, is represented by the equation previously given by Brooke. Tablet dissolution versus time plots, obtained by calculating the equation with a computer, gave an S-shaped curve between the dissolution curve for particles starting at time zero and the curve for particles starting at the tablet disintegration time. The joint influences of disintegration and particle dissolution on the overall tablet dissolution profile also were examined. When dissolution of powders was rapid, disintegration of a tablet directly influenced its dissolution. When powders intrinsically dissolved slowly, the effect of disintegration on the tablet dissolution profile was slight.

Kinetics↗
PubMed1978

Dissolution of nonspherical powders.

To elucidate the effect of particle shape on the dissolution profile of a powder, an equation was derived for the dissolution of powders whose particles are rectangular parallelepipeds and log-normally distributed by introducing three-dimensional parameters instead of diameter in the Brooke equation for the spherical powder dissolution. By using some hypothetical values for constants in the equation, it is shown that the smallest side length, alphao does greatly affect the dissolution profile but that the other two side lengths, and betaalphao, do not, even with rather large values of alpha and beta. Nonisotropic dissolution also is discussed.

Kinetics↗
PubMedDate not supplied

Rapidly progressive deteriorated left ventricular wall motion associated with tetanus: a case report.

A case of tetanus accompanied by severe reversible left ventricular motion impairment is reported. Emergent coronary angiography showed no abnormalities and large akinesis was present on left ventriculography. The plasma catecholamine level was not too high in the acute phase, therefore it is thought that the cause of this depressed left ventricular wall motion abnormality was due to some metabolite derived from tetanus.

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