The subacromial bursa is the major component of the subacromial gliding mechanism. The neural elements of the subacromial bursa obtained from specimens that underwent autopsy and surgery were investigated by the silver impregnation and immunohistochemical methods with antisera to substance P and calcitonin gene-related peptide; which are considered to be involved in nociceptive transmission, and protein gene product 9.5. Free nerve endings, Ruffini endings, Pacinian corpuscles, and two kinds of unclassified nerve endings were observed. Most of these receptors were observed of the roof side of the coracoacromial arch, which is exposed to stress because of the impingement. A delta and C fibers, thought to be nerve fibers of free nerve endings, were immunoreactive to substance P and calcitonin gene-related peptide. On the other hand, thick fibers thought to originate in encapsulated mechanoreceptors were not immunoreactive to substance P. The subacromial bursa receives nociceptive stimuli and proprioception and seems to regulate appropriate shoulder movement.

Adult↗

PubMedDate not supplied

Classification of environmental estrogens by physicochemical properties using principal component analysis and hierarchical cluster analysis.

A structurally diverse assortment of 60 environmental estrogens was divided into two main clusters ("A", "B") and a pair of subclusters ("C1", "C2") by applying principal component analysis to selected 1D and 2D molecular descriptors and subjecting the PCs to hierarchical cluster analysis. Although clustering was predicated solely on physicochemical properties, the dependence on particular physicochemical parameters of xenoestrogen binding affinities (pK(i)) to murine uterine cytosolic estrogen receptor (ER) proved greater for compounds within (sub)clusters than for compounds between (sub)clusters. Quantitative structure-binding affinity relationships derived using molecular descriptors and PCs suggested differences in the driving forces for xenoestrogen-ER binding for different (sub)clusters. The modeling power for xenoestrogen-ER binding affinities of a combination of TLSER and WHIM 3D indices was much greater than that of combinations of 1D and 2D molecular descriptors or the PCs derived therefrom. The clusterings obtained using PCs also proved applicable to the 3D-QSARs.

Chemical Phenomena↗

PubMedDate not supplied

A severe hepatic disorder with myelodysplastic syndrome, treated with cytarabine ocfosfate, in a dog.

An 8-year-old female Shih Tzu was presented with weight loss and vomiting. Alanine aminotransferase was high and abdominal radiographs revealed hepato- and splenomegaly. Mild anaemia, neutrophilia with left shift, eosinophilia, a thrombocytosis with dysplastic features of eosinophils and platelets, were detected. The animal was initially considered to have hepatitis and was treated accordingly, but clinical signs persisted. Histological examination of liver biopsy samples showed disruption of the hepatic lobule, with extensive infiltration by haemopoietic cells. Further investigation of the bone marrow suggested a diagnosis of myelodysplastic syndrome. The animal was treated with cytarabine ocfosfate, a prodrug of cytosine arabinoside, and appeared to recover.

Animals↗

PubMedDate not supplied

The comprehensive health team: a conceptual model.

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Comprehensive Health Care↗