Biomedical subjects

K Ichiyanagi

Publications and source records attributed to K Ichiyanagi.

At least 37 records · Page 2Linked to original sources

PubMed1994

[Quantitative analysis of 123I-BMIPP imaging in relation to exercise-redistribution 201Tl in patients with old myocardial infarction].

Myocardial kinetics of 123I-labeled 15-(p-iodophenyl)3R,S-methylpentadecanoic acid (BMIPP) was evaluated with BMIPP imaging in conjunction with stress-201Tl. We studied 20 patients with old myocardial infarction. BMIPP SPECT was obtained at 20 min and 3 h after injection. On a separate day, exercise stress-201Tl SPECT was performed at 10 min and 3 h after injection. Then, left ventricular myocardium was divided into 20 segments. For quantitative analysis, in each SPECT data, the maximum value (average counts per pixel) of all 20 myocardial segments was taken as 100%; the other values were calculated as a percentage of this maximum (Relative regional uptake, RRU). On the basis of stress-201Tl pattern, the myocardial segments were classified into 4 groups; normal 201Tl uptake, reversible 201Tl defect, fixed 201Tl defect and 201Tl defect with reverse redistribution. The 20 min BMIPP showed reduced activity compared with 3 h-201Tl (p < 0.001), especially in the area of 201Tl redistribution (50/111 segments, 45%), implicating impaired fatty acid utilization at resting condition. The washout rate of the segments with reversible 201Tl defect (-1.6 +/- 13.9%) was significantly lower than that of the segments with normal 201Tl uptake (9.0 +/- 9.8%) and fixed 201Tl defect (3.8 +/- 12.9%). Thus, BMIPP in combination with stress 201Tl imaging provides precise informations of impaired myocardial fatty acid utilization in patients with old myocardial infarction.

Adult↗

PubMed1994

[123I-BMIPP whole-body scintigraphy in relation to left ventricular ejection fraction].

Heart uptake and clearance of 123I-15-(p-iodophenyl)-3(R,S)-methylpentadecanoic acid (BMIPP) by whole-body scintigraphy in relation to left ventricular injection fraction (LVEF) was evaluated in 19 patients with myocardial infarction. At 45 and 210 min after injection, anterior whole-body images were obtained with a single-headed gamma camera system. In each patient, gated blood pool scintigraphy was also performed, and LVEF was calculated. Percent washout from the heart from the 45 to the 210 min imaging positively correlated with LVEF (r = 0.61, p < 0.01), although percent uptake and count density of the heart at 45 min imaging did show any positive correlation with LVEF (r = -0.10 and r = 0.35, respectively). The count density did not correlated with the percent washout (r = 0.32, p = 0.18). Thus, some relationship between LVEF and washout rate of BMIPP from the heart was suggested by analysis of BMIPP whole-body scintigraphy in patients with myocardial infarction.

Adult↗

PubMed1994

Kinetics of iodine-123-BMIPP in patients with prior myocardial infarction: assessment with dynamic rest and stress images compared with stress thallium-201 SPECT.

UNLABELLED: Myocardial kinetics of 123I-labeled 15-(p-iodophenyl)3R, S-methylpentadecanoic acid (BMIPP) were evaluated with dynamic SPECT, and stress and rest BMIPP images were directly compared in conjunction with stress 201Tl. METHODS: We studied 26 patients with prior myocardial infarction. Two minutes after injection of BMIPP, dynamic data acquisition with a three-headed SPECT was started and continued for 12 min. Conventional SPECT images were obtained at 20 min and 3 hr after injection. On a separate day, exercise, stress 201Tl SPECT was performed at 10 min and 3 hr after injection. Exercise stress-BMIPP imaging was performed in 15 of the patients, and static SPECT images were obtained. RESULTS: With dynamic SPECT, early clearance of BMIPP from the myocardium was observed in the segments with reversible 201Tl defects, suggesting enhanced contribution of backdiffusion from BMIPP. In myocardial segments with reversible 201Tl defects, 20-min BMIPP images showed a higher frequency of reduced uptake when compared to 3-hr 201Tl (90/163) imaging. CONCLUSION: With BMIPP dynamic SPECT, an enhanced contribution of backdiffusion in the early phase from ischemic myocardium was suggested. When exercise stress BMIPP images were obtained, a more severe defect was observed than on rest BMIPP and stress 201Tl imaging, possibly due to decreased coronary blood flow and impaired fatty acid uptake induced by ischemia during exercise.

Exercise Test↗

PubMed1993

[Evaluation of early kinetics of 123I-BMIPP in patients with ischemic heart disease].

Early kinetics of 123I-BMIPP was evaluated in 200 left ventricular myocardial segments from 10 patients with old myocardial infarction, employing dynamic SPECT. Dynamic SPECT acquisition was performed from 2 minutes to 14 minutes after injection of 123I-BMIPP. Conventional static SPECT with 123I-BMIPP (BM-S) at 20 min after injection and delayed image from stress 201Tl SPECT (Tl-RD) were visually evaluated by dividing each myocardial segment into the following four groups, NL (the segments with normal radioactivity in BM-S and Tl-RD), Tl < BM (the segments with reduced radioactivity in Tl-RD compared with BM-S), Tl > BM (the segments with reduced radioactivity in BM-S compared with Tl-RD) and Tl = BM < NL (the segments with equally reduced radioactivity in BM-S and Tl-RD). In the dynamic SPECT, washout rate (WR) from 2-4 to 12-14 minutes images was calculated. The WR of Tl > BM group (12.9 +/- 15.5% (mean +/- SD), 55 of 200 segments) was significantly higher than those of NL (-8.6 +/- 11.9%, 95 of 200 segments), Tl = BM < NL (-0.6 +/- 16.0%, 45 of 200 segments) and Tl > BM (-4.4 +/- 9.2%, 5 of 200 segments) groups. This high WR of Tl > BM group may reflect "back diffusion" from myocardium in early phase after injection of 123I-BMIPP.

Adult↗

PubMed1992

The effects of feeding on the development of metabolic acidosis in the rat: comparison between perfused liver in situ and whole animal.

Rat liver perfused in situ was charged with two concentrations of halothane. Lactate increased in a time- and dose-dependent manner in the liver of the fed rat, whereas its increase in the starved rat was much milder (1.7 --> 9.2 mmol. l(-1) vs 0.6 --> 1.4 mmol. l(-1) after a 3 hr charge with 6.0% halothane). Base excess decreased also more markedly in the fed rat. Glucose increased 2.3 times the control value in the fed rat, whereas it did not change significantly in the starved rat. Changes produced by enflurane were very similar to those produced by halothane. It was inferred that in the presence of halothane and enflurane, hepatic glycogen was transformed into glucose and then to lactate by the inhibition of NADH dehydrogenase. In the liver of the starved rat, glucose, hence lactate, did not increase because of the depletion of glycogen. When halothane (1.9%) was given to the whole animal, changes in lactate, base excess and glucose in the arterial blood were very mild. Marked disparities in these parameters between the two experimental models were inferred to be due to: 1) possible insinuation of anaerobic metabolism in the perfusion experiments, 2) a well-kept balance between the suppression of cellular metabolic activity and inhibition of energy production by halothane in the whole animal, and 3) involvement of neural and humoral factors in the intact whole animal.

Journal Article↗

PubMed1992

Acute subendocardial infarction with diffuse intense Tc-99m PYP uptake and minimal Tl-201 abnormality.

Tc-99m PYP scintigraphy performed on a patient with severe anterior chest pain showed diffuse intense uptake with central decreased activity corresponding to the left ventricular cavity. Tl-201 myocardial perfusion scintigraphy at rest revealed a minimal perfusion abnormality with decreased apical uptake in the lateral view. Because of these findings, diffuse subendocardial infarction was suggested.

Acute Disease↗

PubMed1990

Effects of midazolam on the threshold of lidocaine-induced seizures in the dog--comparison with diazepam.

The anticonvulsive effect of midazolam was compared with that of diazepam in ten dogs. Lidocaine-induced seizure waves on the electroencephalogram were used to observe the suppressive effect of the drugs. Midazolam, 0.2 mg.kg(-1), was found to possess a stronger suppressive effect against lidocaine-induced seizures than the same dose of diazepam. These two drugs showed to possess similar effects on cerebral and systemic circulations and cerebral metabolism during seizures.

Journal Article↗

PubMed1988

The role of Ga-67 citrate imaging in pancreatitis.

Two patients with pancreatitis in whom an area of predominant uptake of Ga-67 citrate was demonstrated involving the entire pancreas are presented. Ultrasound and x-ray CT did not reveal any morphologic abnormalities in the pancreas, whereas Ga-67 citrate imaging indicated the presence of active inflammatory change. Ga-67 citrate imaging may be useful in confirming the diagnosis of acute pancreatitis or acute exacerbation of chronic pancreatitis based on clinical and laboratory data, especially when ultrasound and/or x-ray CT cannot reveal any morphologic abnormalities in the pancreas.

Aged↗

PubMed1988