Search PubMed⌕ Search

Biomedical subjects

K Ichihara

Publications and source records attributed to K Ichihara.

At least 343 records · Page 19Linked to original sources
PubMed1975

Difference between endocardial and epicardial utilization of glycogen in the ischemic heart.

In the nonischemic canine left ventricle, levels of glycogen, glucose-6-phosphate (G6P), and lactate, and phosphorylase activity in the endocardial layers were higher than those in the epicardial layers, but the phosphocreatine (PCr) level in the endocardial layers was lower than that in the epicardial layers, and there were no differences in the adenosine triphosphate (ATP) level between the endo- and epicardial layers. Upon ligation of a small branch of the left descending coronary artery, levels of glycogen and PCr decreased, while those of G6P and lactate increased, and the activity of phosphorylase increased. The level of ATP was not affected by the coronary ligation. Thus the coronary ligation accelerated the glycogenolysis and glycolysis in the myocardium without affecting ATP level, and the acceleration in metabolism in the endocardial layers was more rapid and marked than that in the epicardial layers.

Adenosine Triphosphate↗
PubMed1975

Dietary therapy and insulin secretory response to glucose in adult-onset non-obese diabetic subjects.

The effect of a 4-week diet regulation on non-obese, adul-onset diabetics was studied. The diet, which was prescribed for them, was composed of 60% carbohydrate, 15-20% protein and 20-25% fat. The total caloric intake was restricted to 30, 35 and 40 Cal/kg ideal body weight depending on their physical activity. In the group whose calculated diet showed over 10% reduction in total caloric intake and carbohydrate intake, fasting glucose was decreased and glucose tolerance was improved significantly after the 4-week dietary therapy. Insulin response to oral glucose loading was improved, particularly in the later stage of oral glucose tolerance test. As a result, insulin area, i. e. the total area under the insulin curve was increased to almost two times. The sensitivity to insulin did not show any significant changes after diet regulation. The present data indicate that the therapeutic effect of the diet restriction should be at least in part ascribed to the increased secretion of insulin. In the treatment of diabetics, a restricted diet is essential and beneficial from the point of view that it could improve the pancreatic beta-cell function.

Adult↗