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Biomedical subjects

K Hyllested

Publications and source records attributed to K Hyllested.

33 records · Page 2Linked to original sources
PubMed1980

School contact between patients with multiple sclerosis.

We have investigated whether there was more school contact among patients with multiple sclerosis (MS) than expected by chance, suggesting that a transmissible infection occurring at school age might be an aetiologic factor. A case-control-within-a-cohort study was conducted using the 1930-1950 birth cohort. Of 198 000 persons 92 had developed MS in the period 1943-1975 and 3 matched controls for each case were selected. The number of links between all possible pairs of cases was estimated, as well as the number of cases involved in contact with at least one other case. Three measures of school contact were included in the analysis. No evidence of increased school contact among MS cases relative to controls was found.

Adolescent↗
PubMed1980

Risk of multiple sclerosis inversely associated with birth order position.

The aim of this study was to ascertain whether there is an association between risk of multiple sclerosis (MS) and birth order position. Our reference population was 198,000 persons born in the period 1930-50 and recorded in the register of school health records from the school health service of the Copenhagen council. We compared 46 persons from the register who had developed MS with matched controls from the register, three for each case. An inverse association between risk of MS and birth order position was found. Early birth orders tend to delay exposure to an infectous agent from early childhood to a later age. Therefore, our finding supports the hypothesis that MS is causally related to an infection that is inapparent when it occurs in early childhood, while infection later in life may result in severe disease

Birth Order↗
PubMed1979

Multiple sclerosis in the Faroe Islands: I. Clinical and epidemiological features.

Intensive search over the past five years for all cases of multiple sclerosis (MS) on the Faroe Island since about 1920 has revealed 25 cases among native-born resident Faroese up to 1977. All but 1 patient had clinical onset of MS between 1943 and 1960; 1 case began in 1970. Four cases of MS in Faroese with prolonged foreign residence and 5 among Danish-born Faroese were excluded. The 24 included cases with onset between 1943 and 1960 meet all criteria for a point-source epidemic. The median year of onset was 1949. The cumulative risk of MS for Faroese in 1940 was 8.7 per 10,000. All 14 early-onset cases (1943 to 1949) were in patients 11 to 45 years old in 1940; all but 2 late-onset cases (1952 to 1960) were in persons aged up to 10 years old in 1940. British troops occupied the Faroese in large numbers for five years beginning in April, 1940. During the war, all but 3 patients resided in locations where the troops were stationed, and these 3 also had direct contact with the British. We conclude that there was an epidemic of MS on the Faroes and that the disease was probably introduced by the British troops (or their baggage). If so, then MS on the Faroes is a transmissible disease, most likely infectious; but only about 1 in 500 of the exposed individuals were clinically affected.

Adolescent↗
PubMed1976

Lysolecithin fusion of cells from multiple sclerosis patients with Vero cells.

Investigations were performed on cell cultures derived from patients with multiple sclerosis (MS) in order to trace a possible virus infection as a cause of the disease. Cell cultures were established from one brain autopsy specimen and four lymph node biopsies from MS patients. Lymphocytes from 28 MS patients and six healthy controls were used for fusion or cocultivation experiments, either immediately after isolation or after mixed lymphocyte cultures (MLC). Lysolecithin fusion and cocultivation experiments were made with Vero cells and with, respectively: cultured brain cells, lymph node cells and lymphocytes from MS patients. Electron microscopical examination revealed intranuclear filamentous structures in 5 per cent of the cells in primary cultures of MS brain and lymph node and in control skin organ cultures. Multinucleated cells were found in six out of 19 cocultures of Vero cells and MS lymphocytes preincubated for 2 days at 37 degrees C. The cultures were tested for the presence of viruses, i.e. measles virus and virus producing hemadsorption with human type O and/or guinea pig erythrocytes and virus against which the MS patients showed serum FA-antibodies. No virus antigen could be demonstrated in the cells.

Adult↗
PubMedDate not supplied

MS epidemiology in Faroe Islands.

We found 41 Faroese with clinical onset of MS 1900-1983, including 9 "migrants" who had lived in (high MS risk) Denmark for 3+ years before onset. Their major foreign residence was during the 10 years or so before clinical onset, began at age 11-29 and was of at least 2 years duration, following which clinical onset occurred an average of 6 years later. Among the 32 resident Faroese, clinical MS began between 1943 and 1973 and comprised three epidemics, each one significantly later in time and lower in incidence than the preceding. The risk of MS for Faroese of epidemic I, who acquired the disease from asymptomatic British troops in the World War II occupation, was 18 per 10,000. Risk for those of epidemics II and III, who acquired the disease from asymptomatic but affected Faroese, was not significantly different. We conclude that the primary MS affection (PMSA) is a single, widespread infectious disease whose acquisition in virgin populations follows two years of exposure starting between age 11 and 45, which then produces clinical neurologic MS (CNMS) in only a small proportion of the affected after an incubation period of 6 (virgin populace) or 12 (endemic areas) years, and which is transmissible only during the systemic PMSA phase which ends by age 27 or younger.

Adolescent↗