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Biomedical subjects

K Huttunen

Publications and source records attributed to K Huttunen.

47 records · Page 3Linked to original sources
PubMed1983

Surgical treatment of unstable angina pectoris.

During the years 1977-1980, 47 patients with unstable angina pectoris underwent coronary artery bypass grafting within on an average 16 days after onset of angina. A total of 90 grafts were inserted (1.9 grafts per patient). There were no early deaths in patients operated on for unstable angina. Two late deaths (4.2%) occurred during a follow-up period varying between 14 and 62 months, mean 38 months. Two patients (2.1%) sustained perioperative infarction and two patients (4.2%), late myocardial infarction. All patients were symptomatically improved following operation and 32 (72.7%) are entirely asymptomatic. The authors conclude that patients with unstable angina pectoris can safely undergo early arteriography and semielective operation with results comparable to that for operation in patients with stable angina pectoris.

Angina Pectoris↗
PubMed1983

The determination of natural killer activity of human peripheral blood lymphocytes by measuring the DNA-synthesis of proliferating target cells (K 562 cell line).

Natural killer (NK) activity of human peripheral blood lymphocytes was determined by measuring 3H-thymidine incorporation into proliferating highly NK-sensitive K 562 target cells alone and in the presence of effector cells. Although the absolute figures varied, depending mostly on the strength of DNA-synthesis of the target cells on the day of the assay, the results were highly reproducible and compared well with those of the 51Cr-release assay (CRA). The method was extremely simple and less tedious than CRA. The interpretation of the data was facilitated by including known control cells of low and high NK activity. The cells less sensitive to NK activity did not seem to be suited for this kind of assay.

Cell Line↗
PubMed1982

Effects of renal transplantation on left ventricular size and function.

Thirteen patients with chronic renal failure and uraemia were investigated by echocardiography preoperatively before and after haemodialysis and again after a successful renal transplantation to evaluate the cardiac changes caused by renal transplantation. After renal transplantation, the left ventricular end-diastolic and end-systolic diameters, as well as the cardiac index, decreased, probably because of the decreased left ventricular filling pressure. The left ventricular wall thickness and mass decreased, apparently as a result of the decrease of the left ventricular preload and also of the decrease of the afterload, because the systolic blood pressure decreased. The left atrial diameter decreased in response to the decreased left ventricular preload and wall hypertrophy. The changes in the indices of left ventricular function as a result of haemodialysis appeared to predict the changes seen after renal transplantation. Renal transplantation appears to have a tendency to result in normal left ventricular and left atrial volumes, as well as to lessen left ventricular hypertrophy, without significantly improving left ventricular function.

Adult↗
PubMed1982

99mTc-DTPA--a useful clinical tool for the measurement of glomerular filtration rate.

The single injection 99mTc-DTPA clearance was compared with the inulin clearance performed with the constant infusion technique in 22 subjects. There was a good correlation between these two methods (r = 0.968, p less than 0.001). Although the single injection technique calculated by one compartment model is not accurate enough for research purposes, it seems to work well in routine clinical practice for the measurement of glomerular filtration rate using 99mTc-DTPA as a tracer substance. The performance is simple, it needs only a few blood samples, nor does it need any urine collection, the radiation dose is low and it seems to be more accurate than the endogenous creatinine clearance.

Adolescent↗
PubMed1982

Natural killer cell function in trisomy-21 (Down's syndrome).

Natural killer (NK) activity and antibody-dependent cell mediated cytotoxicity (ADCC) against a human myeloid target cell line (K 562) was measured in adult patients with trisomy-21 (Down's syndrome) and in chromosomally normal age and sex matched control subjects. The effect of human leucocyte interferon (IFN-alpha) on the NK activity was also estimated. Spontaneous NK activity was stronger in the adult patients with trisomy-21 than in the healthy controls, but the difference did not reach statistical significance. The augmentation of NK activity by IFN-alpha, measured using lymphocytes not depleted of monocytes as effector cells, was statistically significant in both the trisomic patients (P less than 0.004) and the healthy controls (P less than 0.0005). Using monocyte and macrophage depleted lymphocytes in the patients with trisomy-21 the NK activity proved stronger than in the healthy controls, but not significantly and IFN-alpha did not augment it as it did in the healthy controls (P = n.s., P less than 0.05), for augmentations respectively). These results support the view that monocytes and macrophages are connected with the NK cell system. ADCC correlated with NK activity in both groups. Since NK cells are important components of many immune processes, including tumour and virus and/or bacteria-infected cell elimination, and have regulatory functions in immune reactions, the deficient augmentation of trisomic NK cells shown in vitro with extrinsic human leucocyte interferon may, paradoxically be an explanation for the greater susceptibility of trisomic individuals to lymphatic leukaemia and virus and bacterial infections. In vivo, this could be explained by the more potent secondary suppression by the 'immune' interferon produced by the virus, bacteria and malignant cells. In other words, the potential of the 'fighting couple' of the immune system, NK cell/interferon, is perhaps disturbed genetically due to the chromosome 21.

Adult↗
PubMed1982

Prostacyclin and thromboxane in chronic uremia: effect of hemodialysis.

To study the effects of uremia and hemodialysis on the production rates of antiaggregatory prostacyclin (PGI2) and proaggregatory thromboxane A2 (TxA2), we collected serial plasma samples from eight patients with chronic uremia before, during and after hemodialysis and assayed them for 6-keto-PGF1 alpha and TxB2, the stable metabolites of PGI2 and TxA2, respectively. In addition, the capacity of the platelets to produce TxB2 during spontaneous clotting was studied by measuring the TxB2 levels in serum incubated at +37 degrees C for 60 minutes. The PGI2 production of the uremia patients before hemodialysis was less (P less than 0.001) than that of healthy volunteers. It rose significantly following heparinization and remained elevated during hemodialysis. TxB2 generation by platelets during clotting was diminished in uremia. Plasma TxB2 levels were normal before, but increased during hemodialysis. Thus, profound changes in the PGI2/TxA2-system seem to be associated with uremia and hemodialysis.

6-Ketoprostaglandin F1 alpha↗
PubMed1977

Peroperative infusion of dextran 70 and dextran 40 in the prevention of postoperative deep venous thrombosis as confirmed by the I-125-labelled fibrinogen uptake method.

The antithrombotic effect of dextran 70 and dextran 40 was studied by a double blind trial in 235 patients with major or medium sized elective procedures. 6% dextran 70 (Macrodex) or 10% dextran 40 (Rhemacrodex) or 5% dextrose in 0.9% saline were given in a double blind manner in 500 ml quantities over 30 minutes starting with the induction of anaesthesia. The diagnosis of deep venous thrombosis was confirmed objectively by the I-125-labelled fibrinogen uptake method. Statistically significant differences in the incidence of deep venous thrombosis between the controls and the dextran groups were not found.

Clinical Trials as Topic↗