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Biomedical subjects

K Huibregtse

Publications and source records attributed to K Huibregtse.

At least 145 records · Page 8Linked to original sources
PubMed1982

Palliative treatment of obstructive jaundice by transpapillary introduction of large bore bile duct endoprosthesis.

The endoscopic techniques for introducing a large calibre (3.2 mm) biliary endoprosthesis to relieve jaundice are described. In 45 patients such an endoprosthesis was successfully introduced. The median survival time in 18 patients was 41 days (range three to 187). Twenty-six patients are still alive after a median of 28 days (range seven to 244). One patient had a surgical bypass after 24 days. Short-term complications were cholangitis and fever in 11 patients. Late complications were recurrent jaundice in four, upward migration of the endoprosthesis in two, and clogging of the endoprosthesis in one patient. The risk of cholangitis, which used to be a major problem with transpapillary introduced prostheses of smaller calibre, seems definitely diminished by using one with a large calibre.

Adult↗
PubMed1982

Effect of 15(R)-15-methyl prostaglandin E2 (arbaprostil) on the healing of duodenal ulcer: a double-blind multicenter study.

A multicenter study was conducted on 173 patients with active, endoscopically proven duodenal ulcers (158 men, 15 women). They were randomly assigned, in a double-blind manner, to two groups: those receiving placebo capsules (91 patients) and those receiving capsules containing 100 microgram of 15(R)-15-methyl prostaglandin E2 (arbaprostil) (82 patients). Each drug was ingested four times a day (1 h before meals and at bedtime) for 28 days. Endoscopy was performed on days 0, 14, and 28 after the trial began. At each examination, the ulcer size was measured and whether the ulcer had healed was recorded. Arbaprostil increased the incidence of ulcer healing to approximately the same degree as reported in most extensive studies with cimetidine. At 14 days, three times as many patients were totally healed in the arbaprostil-treated as in the placebo-treated group (37% vs. 12%, p less than 0.001). At 28 days, 67% of patients receiving arbaprostil were healed compared with 39% in the group receiving placebo (p less than 0.001). Similarly, the ulcer size, measured endoscopically, was much smaller after arbaprostil administration than in the group receiving placebo after both 14 and 28 days (p less than 0.001). Side effects attributable to treatment consisted primarily of loose stools and diarrhea (34%). Smoking retarded healing in the placebo-treated group (p less than 0.05), but did not significantly retard healing in patients treated with arbaprostil. We conclude that arbaprostil markedly accelerates the healing rate of active duodenal ulcers. This effect may be due to inhibition of acid secretion as well as gastric cytoprotection.

Adolescent↗
PubMed1982

Results of conservative treatment of benign esophageal strictures: a follow-up study in 100 patients.

The results of a conservative treatment of benign esophageal strictures (68 peptic, 21 postsurgical, 2 caustic stenoses, 8 Schatzki rings, 1 esophageal web) were evaluated in 100 patients. Treatment consisted of dilatation either with Eder-Puestove olives or with mercury bougies up to 18-20 mm, or with both. In addition, all patients received antireflux therapy when indicated. The follow-up study lasted from 1-6 yr. The results show that 88 patients became symptom-free. In 4 patients the results were moderate (intermittent dilatation necessary), while there were three failures: all in patients with a severe ulcerating peptic reflux esophagitis with stenosis. They were treated by antireflux surgery. There were eight perforations; all patients survived after surgical (4) and conservative (4) treatment; 3 patients received further dilatation. Conservative dilatory treatment (up to 18-20 mm), combined with antireflux therapy when indicated, offers in general an adequate result in patients with benign esophageal strictures.

Adult↗
PubMed1981

The effect of 15(R)-15-methyl prostaglandin E2 on basal and meal stimulated serum gastrin in duodenal ulcer patients.

Basal and meal-stimulated serum gastrin with or without prior intake of 100 mcg 15(R)-15-methyl prostaglandin E2 (PG) in encapsulated form were measured in 40 patients with active duodenal ulcer disease at the start and at the end of a 4 week treatment period with 100 mcg PG q i d or placebo (Pl). Basal serum gastrin levels did not change throughout the study. Neither was there a blunting of the meal-stimulated serum gastrin release by PG as has been previously observed. The enhanced healing rate (68.4% during PG compared to 33.3% during Pl) can therefore not be explained by changes in basal or meal-stimulated serum gastrin.

Adult↗
PubMed1981

Transpapillary positioning of a large 3.2 mm biliary endoprosthesis.

An endoscopic method for positioning a large-caliber (3.2 mm) biliary endoprosthesis is described. In 3 patients with malignant jaundice the endoprosthesis provided definitive relief of jaundice until death 4 1/2, 15 and 17 weeks respectively after the introduction of the prosthesis.

Aged↗
PubMed1981

Effects of Mg++ and Ca++ on water absorption from rodent and human intestine.

The effect of the soluble chlorides of Mg++ and of Ca++ on intestinal water absorption was compared in rodents and in humans because Mg++ is a laxative while Ca++ is reputed to be constipating. In rats, net water transport in vivo from segments of jejunum or of colon was similar during control periods with NaCl, 275 mosm/kg, and during test periods when 40 mM CaCl2, or MgCl2 (made isoosmolal with NaCl) was infused. Both CaCl2 and MgCl2 depressed water absorption in ileal segments by 30-40% compared with NaCl. In man, 6 ileostomy patients were given 60 mmole CaCl2 or MgCl2, orally over 24 h for 3 days in a randomized, cross-over trial. CaCl2 increased the average ileostomy output from 984 to 1,336 g/day; MgCl2 increased output from 939 to 1,352 g/day. A corollary of these results was that magnesium hydroxide would be less effective laxative when this insoluble hydroxide is not converted to soluble chloride by gastric juice. To test this inference, 5 totally gastrectomized patients were given 60 mmole of Mg(OH)2 or MgCl2 daily. Stool weight increased by 136 g after MgCl2 but not after Mg(OH)2.

Animals↗
PubMed1977

Intestinal propulsive action of oxetoron.

In a double blind placebo controlled study of 40 patients, oxetoron was shown significantly to shorten the time required for movement of a small intestinal biopsy capsule up to the angle of Treitz.

Adolescent↗
PubMed1977

Bile acid metabolism in ileostomy patients.

In ten ileostomy patients, a 14C-cholylglycine breath test was performed. The 14CO2 in the exhaled air and the 14C bile acid quantity and composition and fat content in the subsequent 24 h ileostomy effluent were determined and compared to the values in twenty healthy controls. The results show that in ileostomy patients only minor bile acid-deconjugation occurs in vivo. Deconjugation in the ileostomy bags was found to be mainly responsible for the absence of conjugated bile acids in many of the ileostomy effluent samples. Secondary bile acids were not present in these patients, as determined by TLC. The fecal fat and bile acid excretion was found to be in the normal range in ileostomy patients provided no concomitant ileum resection was present.

Bile Acids and Salts↗