Biomedical subjects
K Holubar
Publications and source records attributed to K Holubar.
"Dermatology:" the name of the game and its development.
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Ethics of organ transplantation.
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[Apropos of the editorial by E. Grosshans and R. Tomb: 1492-1992: 500 years ago Christopher Columbus rediscovered America. Rediscovery of dermatoses already described].
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At the crossroads 200 years ago: dermatology versus dermato-pathology: Seguin Henry Jackson (1752?-1816) and his treatise of 1792.
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[Paul de Sorbait (1624-1691): on the 300th anniversary of his death].
The life of Paul de Sorbait (1624-1691), who was Professor of Medicine, Dean of the Medical School, and Rector Magnificus at Vienna University, is reviewed on the occasion of the 300th anniversary of his death.
Regarding: comment on the paper: Russell, G.A.: Physicians at the Ottoman Court.
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William Chamberlaine (1747-1822) and his Fothergillian Medal.
The Fothergillian Medal is awarded by the Medical Society of London for medical distinction. It was first presented in 1787 and, apart from a short interval 1803-1824, it has continued to be awarded until the present day. Of the original seven gold medals cast, only two are preserved. However, the Brettauer Collection in Vienna contains an unusual (third) Fothergillian Medal cast not in gold but in gilded silver, which is dedicated to William Chamberlaine. A search of the archives of the Medical Society of London has revealed the identity of William Chamberlaine who was Honorary Secretary of the Medical Society of London for eight years, and was awarded this special Fothergillian Medal in recognition of his services.
[Josef Tappeiner on his 70th birthday].
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[Mycosis fungoides bullosa--a case report (author's transl)].
An extremely rare variant of mycosis fungoides, presenting with bullous lesions, is reported. Histopathological examination of the skin revealed subepidermal blister formation, a diffuse mononuclear infiltrate in the uppermost parts of the dermis and the characteristic intraepithelial Pautrier microabscesses. Lutzner cells were found at the ultrastructural level. The mechanism of blister formation in mycosis fungoides is outlined.
Ultrastructural localization of immunoglobulin and fibrin in lichen planus.
To demonstrate the exact localization of immunoglobulin and fibrin deposits in skin lesions of lichen planus, we employed the peroxidase-antiperoxidase technique, both light and electron microscopically. IgM is shown to be deposited preferentially in and on the cytoid bodies all over their cut surface in a typical stippled pattern, partly obscuring the characteristic fibrillar substructure. All other structures such as the basal lamina are devoid of IgM deposits. Fibrin (F) is also present in cytoid bodies but in a lesser amount; it is characteristically deposited on and along the basal lamina and its reduplications in the uppermost strata of the dermis. Our results indicate that IgM deposition in cytoid bodies occurs at a very early stage during the formation of these structures and that fibrinogen exhibits a specific affinity not only to cytoid bodies but also to basal lamina material.
Failure to detect gliadin or gliadin binding sites in the skin of patients with dermatitis herpetiformis: immunofluorescence, organ culture and autoradiographic studies.
Recent investigations indicate an abnormal binding of gluten or gliadin to lymphocytes or intestinal mucosa cells in gluten sensitive enteropathy. Since dermatitis herpetiformis is closely associated to gluten sensitive enteropathy, similar receptors could also exist in the skin of patients with dermatitis herpetiformis. To prove this hypothesis, skin of normal volunteers and uninvolved skin of 3 patients with dermatitis herpetiformis was investigated for the presence of gliadin and gliadin binding sites. In vivo bound gliadin was not found by direct immunofluorescence using 3 different rabbit antigliadin antisera. In order to test skin for gliadin binding sites, normal sera and autologous dermatitis herpetiformis sera containing 25 mg% gliadin and tritium labeled gliadin, respectively, were used for incubation of normal and dermatitis herpetiformis skin cryocut sections and of normal and dermatitis herpetiformis skin specimens, grown under organ culture conditions. As checked by direct immunofluorescence and autoradiography, there was no specific in vitro binding of gliadin, indicating that gliadin does not fix to normal human or dermatitis herpetiformis skin. Thus, the role of gliadin in the fixation in vivo, of antibodies or immune complexes to skin in dermatitis herpetiformis, remains obscure.
Juvenile dermatitis herpetiformis: an immunoelectron microscopic study.
Three children with persistent maculopapular and urticarial lesions and vesicles at the predilection sites of dermatitis herpetiformis (DH) were shown to exhibit typical granular, papillary IgA and C3 deposits in the tips of the dermal papillae, as demonstrated by direct immunofluorescence. By immunoelectron microscopy, the IgA deposits were associated with the microfibrils of the elastic fibres as has been described in DH of the adult. C3 deposits were scattered throughout the papillary dermis. Despite the similarity of the clinical appearance, history with regard to gluten sensitive enteropathy (GSE) varied in these three cases. In one child, the skin lesions appeared following faults in the gluten free diet on which he was kept for coeliac disease. Another child developed the skin lesions during a gluten free diet which was not strictly followed; no recurrences of gastrointestinal symptoms accompanied the eruption of DH. In the third case, no evidence for GSE in patient's history or in jejunal biopsies was present at the time of onset of DH.
[Diagnosis of lupus erythematosus].
For the exact classification of lupus erythematosus, morphological criteria alone (clinical picture, histopathology, immunopathology from involved skin, immunoelectron microscopy) are not sufficient. It is the aim of this paper to discuss briefly the known criteria for the diagnosis of systemic lupus erythematosus with particular reference to the interpretation of more recent deagnostic methods (determination of certain antinuclear antibodies; lupus band test; C1q-binding assay.
[Immunologic examination methods in dermatology diagnosis].
A survey is made of current usage of immunological test systems with regard to dermatology in general, and the practical importance of these techniques for the practizing dermatologist. Humoral and cellular immune systems are outlined; immunofluorescence, and determinations of cellular immune parameters are covered in more detail.
[Immunopathology of Duhring's dermatitis herpetiformis].
Dermatitis herpetiformis and gluten-sensitive enteropathy and their mutual association are discussed. Clinical, histopathological, immunopathological and genetic findings are emphasized, particularly with regard to the pathogenesis and diagnosis of both disorders.