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Biomedical subjects

K Holli

Publications and source records attributed to K Holli.

63 records · Page 4Linked to original sources
PubMed1990

Prognostic factors in recurrent breast cancer: relationships to site of recurrence, disease-free interval, female sex steroid receptors, ploidy and histological malignancy grading.

Site of first recurrence, disease-free interval (DFI), female sex steroid receptors, ploidy measurements as well as histological grading have been analysed as potentially valuable predictive factors in 313 cases of recurrent breast cancer. Univariate and multivariate analyses show histological grading, site of recurrence and disease free interval to be useful prognostic variables when assessing prognosis once disease has recurred. High concentrations of oestrogen receptors (ER) were found in patients with bone metastases, whereas lower concentrations of ER were related to visceral recurrences. Ploidy measurements failed in this study to give any predictive information once disease recurred.

Breast Neoplasms↗
PubMed1989

Treatment of the terminal stages of breast cancer.

To assess the intensity of and changes in diagnostic investigations and treatment in the terminal stages of breast cancer 555 patients in the area of Tampere University Central Hospital in whom breast cancer had been diagnosed from 1977 to 1980 were followed up for five years. The case notes for the last visit of 519 patients were analysed. The amount of diagnostic activity was similar for those who died and for the survivors. A higher proportion of women who died than of women who survived received treatment at the last follow up visit, and 2.6 times as many of those dying within one week of the last visit were given chemotherapy as were survivors with recurrent disease. Resources devoted to diagnostic investigations and treatment of cancer in terminally ill patients could be better used for care of the patients. This would be more likely to improve the patients' quality of life and conserve resources.

Breast Neoplasms↗
PubMed1989

Effectiveness of routine and spontaneous follow-up visits for breast cancer.

The effectiveness of routine (initiated by the health services) and spontaneous (initiated by the patient) follow-up visits were compared based on a 5 year follow-up of all (551) breast cancer patients residing in one of the Finnish central hospital districts and diagnosed in 1977-1980. There were altogether 8248 visits, i.e. 4.6 per follow-up woman year, of which 2.7 visits were based on the recommended follow-up schedule. Recurrence (252) was detected in 14.7% of spontaneous visits which was five times more often than at the regular visit. False positive clinical diagnosis (63) was three times more frequent for spontaneous than for regular visits. The follow-up system should probably not be based solely on detecting of recurrences of the disease only but aspects related to the patient's quality of life may be decisive.

Breast Neoplasms↗
PubMed1986

Value of chest radiography in follow-up of treated breast carcinoma.

We reviewed the clinical records and over 1900 chest radiographs of 218 patients with carcinoma of the breast. The patients were treated with surgery and radiation therapy. During the two-year follow-up pathological signs were seen in the chest radiographs of 103 patients (47%). Irradiation changes were found in 51 patients (23%); in 28 patients (13%) there were pulmonary metastases; and eleven patients had metastases of bony thoracic cage. 36% of patients with metastases had no symptoms. In eight patients other unexpected findings were observed, such as tuberculosis and sarcoidosis. Obviously, periodical chest radiographs are beneficial and advisable in the follow-up of patients with carcinoma of the breast.

Bone Neoplasms↗
PubMedDate not supplied

Postoperative PINP in serum reflects metastatic potential and poor survival in node-positive breast cancer.

The aim of this work was to evaluate the postoperative serum markers of type I collagen synthesis (PINP,PICP) and degradation (ICTP) and their possible potential for predicting the spread of disease and survival. 373 node-positive breast cancer patients were enrolled. 120 patients (32%) developed recurrent disease in the follow-up. The mean time to recurrence was 17 months and the mean follow-up time was 45 months. The mean level of PINP was significantly elevated in the patients who developed metastatic disease in the follow-up as compared with those without metastases. PINP was statistically significantly higher in all the patients who developed bone metastases than in those without metastases. When patients with only bone metastases or patients with bone and soft tissue and/or visceral metastases and patients with only visceral or soft tissue metastases were compared with those not exhibiting metastases, PINP was significantly higher in the group with recurrence in the bone, but there were no significant differences in serum PINP, PICP or ICTP values between the patients with only bone metastases and those who developed soft or visceral metastases during the follow-up. Postoperative high PINP was also a factor for poorer survivaL Tumor size, malignancy grade and progesterone receptors were shown in multivariate analysis to be predictors of recurrence and tumor size and PINP and progesterone receptors to be predictors of survivaL

Antineoplastic Agents, Hormonal↗