Search PubMed⌕ Search

Biomedical subjects

K Hojo

Publications and source records attributed to K Hojo.

At least 163 records · Page 9Linked to original sources
PubMed1976

Lesions associated with familial polyposis coli: studies of lesions of lesions of the stomach, duodenum, bones, and teeth.

The entire gastrointestinal tract and bones were examined systematically in 24 patients (10 pedigrees) in whom familial polyposis coli was diagnosed. Polypoid lesions were observed in the stomach in as high as 68.2% of the cases, and in the duodenum in 90%. Abnormalities were noted in the skeleton in 50% and in the mandible in 81.3%. The authors emphasize the possibility that familial polyposis coli is substantially the same entity as Gardner's Syndrome.

Adolescent↗
PubMed1976

Dissociation of MIF activity and in vitro lymphocyte transformation in the development of experimental allergic thyroiditis in guinea pigs.

Macrophage migration inhibitory factor (MIF) activity and in vitro lymphocyte transformation to homologous thyroid antigen were compared in cultures of lymph node cells obtained from 123 guinea pigs at weekly intervals after a single injection of homologous thyroid extracts in complete Freund's adjuvant (CFA). MIF activity was not detectable at the early stage of immunization but became manifest 2 and 3 weeks after sensitization and a high level was maintained during 4-7 weeks. On the other hand, lymphocyte transformation preceded the appearance of MIF activity and attained its maximum 2 weeks after sensitization before the establishment of thyroiditis. It is indicated that MIF activity and lymphocyte transformation predominate separately in the course of immunization. There was a considerable correlation between intensity of MIF activity and severity of thyroiditis in individual animals during the advanced stage (4-6 weeks after sensitization) of the disease. Also, a lower but significant correlation was seen between lymphocyte transformation and severity of thyroiditis. However, about half of animals in the advanced stage of thyroiditis failed to exhibit antigen-stimulated lymphocyte transformation, despite a positive MIF activity.

Animals↗
PubMed1976

Effects of inhibitors of DNA and protein syntheses on mitogenic factor production by PPD-stimulated guinea pig lymphocytes.

The effects of inhibitors of DNA synthesis and mitosis and of protein synthesis on mitogenic factor production by lymph node cells from guinea pigs sensitized to tuberculin was studied. All inhibitors used in this study were added to the medium at the beginning of culture. Cytosine arabinoside, vinblastine and mitomycin-C reduced markedly the incorporation of tritiated thymidine in DNA, but had no effect on the production of mitogenic factor. Mitomycin-C at higher concentrations, however, induced the partial reduction of mitogenic factor production. On the other hand, puromycin and cycloheximide, inhibitors of protein synthesis, suppressed markedly the production of mitogenic factor. These results indicate that mitogenic factor production requires protein synthesis, but is independent of DNA synthesis.

Animals↗
PubMed1975

In vitro lymphocyte transformation in the development of experimental allergic thyroiditis.

In vitro lymphocyte transformation to homologous thyroid antigen has been studied in cultures of lymph node cells obtained from 97 guinea pigs at weekly intervals after a single injection of homologous thyroid extract in complete Freund's adjuvant, using a method for measurement of 3-H-thymidine incorporation. Lymph node cell cultures from animals 1 week after sensitization showed a significant increase in thymidine incorporation after the addition of antigen. Two weeks after sensitization the stimulation was maximal, and then a lower but significant response continued during the next 5 weeks. There was no correlation between lymphocyte transformation and the level of circulating antibodies throughout the post-sensitization period examined. The early lymphocyte transformation contrasted with the later development of macrophage migration inhibitory factor activity.

Animals↗
PubMed1972

[Amyloidosis].

Explore the source record for details and available documents.

Amyloidosis↗