Alpha1 (alpha 1) fetoprotein (AFP) radioimmunoassay method was routinely used in addition to liver scintigraphy to detect a primary hepatic cell carcinoma, and the diagnostic accuracy of both methods was compared. Twenty-one of 27 cases (78%) with primary hepatic cell carcinoma showed a positive AFP titer of over 200 ng/ml. In 3 of these AFP-positive cases, no focal defects could be found in liver scintigraphy, although subsequently performed celiac angiography revealed hypervascular shadows. On the contrary, 22 of 27 cases (81%) represented well-defined focal defects on scintigraphy. In 4 of these cases with a positive scan, the result of AFP was found to be negative. The overall diagnostic accuracy for detecting primary hepatic cell carcinoma with a combination of both methods was 93%.

Carcinoma, Hepatocellular↗

PubMed1975

Clinical evaluation of tumor scanning with 169-Yb-citrate.

169-Yb-citrate was used as the tumor-scanning agent in 360 patients with malignant tumors and in 55 others with benign lesions and the results compared with 67-Ga-citrate studies in other series. In malignant tumors, the overall positive detection rate for ytterbium was 65.3%; in benign lesions, the false-positive rate was 29.1%. Good results were obtained in the extremities, head and neck, and pelvic area. Of all tumors visualized, squamous cell carcinoma was detected most effectively (77.5%). 169-Yb-citrate has a long shelf life, photon peaks of 178 and 198 kev, clears from the blood more rapidly than 67-Ga-citrate and has an extremely low soft-tissue background uptake. Its main disadvantage is its high radiation dose: 1.74 R/500 muCi whole-body and 5.77 R to the bone.

Abdominal Neoplasms↗

PubMed1975

Brain scan in cerebrovascular "Moyamoya" disease.

Brain scans were abnormal in 2 of 6 patients with cerebral "Moyamoya" disease. The spatial and temporal scan patterns were analogous to those described in conventional cerebral infarction. Cerebral infarction due to emboli resulting from mural thrombi may explain the uptake of radioisotope. None of the scans was abnormal in 4 adult patients in which the disease was complicated by subarachnoid hemorrhage.

Adolescent↗

PubMed1975

Whole body transmission-emission scanning with whole body camera.

Whole body transmission-emission scanning was carried out using a whole body camera. A disk source 30 cm in diameter filled with 99mTc was used for transmission scanning. Correct interpretation of emission scanning requires accurate anatomical orientation of the images. The value of whole body transmission-emission scanning is emphasized.

Aged↗

PubMed1975