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K Hinokuma

Publications and source records attributed to K Hinokuma.

30 records · Page 2Linked to original sources
PubMed1987

[Clinical study of traumatic cerebellar contusion].

Numerous authors have reported cases of traumatic cerebellar contusion. A few authors have emphasized delayed deteriorations in patients with cerebellar contusion. Since CT scan was introduced into daily clinical practice, it has become obvious that cerebellar contusion were not necessarily associated with severe head injuries. Of 1176 head-injured cases admitted to our department in the past five years, eight (0.7%) were diagnosed by CT scans to have cerebellar contusion. Among eight cases, two of them were deeply comatose on admission because they had concomitant diffuse cerebral contusions and died soon after admission. Remaining six cases had predominantly cerebellar contusion on CT scans and showed minimal neurological deficits on admission. Most of them recovered without any significant disabilities. But two of them deteriorated several hours after injury, showing brain-stem compression for which emergency posterior fossa decompression were carried out without recovery. One of them underwent external decompression which resulted in intracerebellar massive hemorrhage and the other missed the timing of surgery. In conclusion, it is important to prepare for unexpectedly rapid deterioration, for which wide craniectomy and sufficient internal decompression would be required.

Adult↗
PubMed1985

[Brain tumor induced in dogs by intracerebral inoculation of SR-RSV induced cultured tumor cells--electron microscopic study].

An experimental transplantable canine brain tumor model with the advantages of rapid tumor growth within 10 days and relative safety for the investigator is presently available. The tumor is produced by intracerebral inoculation of cultured cells derived from a canine brain tumor induced by the Schmidt-Ruppin strain of the Rous-Sarcoma virus (SR-RSV). It has potential use as a model in experiments designed to evaluate the effectiveness of chemotherapy and radiotherapy with serial computerized tomography scans. However, characterization of the induced tumor is essential. Ideally, it should have features attributable to glioma and/or neuroectodermal tumors. Utilizing the technique of intracerebral inoculation of cells cultured from the original dog brain tumor induced by SR-RSV, Salcman et al identified the tumor they induced in brains of mongrel puppies as a glioma by light microscopic criteria (Reference). The purpose of our study was to further characterize this experimental tumor by electron microscopic and immunohistochemical techniques. Tumor was induced in 6 mongrel puppies. Stains of the tumor for immunohistochemical reactivity to glial fibrillary acid protein, S-100 protein and 210K neurofilament protein were all negative. With the electron microscope, the intracerebral tumor cells were mostly undifferentiated. They had a few cell processes, occasional punctate adhesions and some microvilli-like structure. The tumor cell nucleus was usually oval shaped and sometimes had nuclear indentations. The cytoplasm contained abundant free ribosomes, some rough endoplasmic reticulum and mitochondria. Collagen fibers and basal lamina were not observed in the intercellular spaces. The capillaries within the tumor were characterized by proliferation of immature endothelial cells which were non-fenestrated.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1984

Traumatic intracerebral haematomas of delayed onset.

25 cases of traumatic intracerebral haematomas of delayed onset were found among 775 cases of acute head injuries. All these 25 cases were analysed both clinically and with computed- tomographical studies. Their clinical features were different from those of classical " traumatische Spät- Apoplexie " originally described by Bollinger in 1891, in the following aspects; absence of the symptom-free interval and absence of apoplectic onset of symptoms after a relatively long lucid interval. These traumatic intracerebral haematomas of delayed onset were, on the other hand, characterized by the following; the patient was injured when the head was in motion, the injury was not necessarily severe, the onset of signs and symptoms were gradual and insidious, all 25 cases but 4, had cranial vault fractures and/or basal skull fractures, precipitating factors could not be identified, though hypotensive episodes were present in 60% of cases, intracerebral haematomas appeared within 72 hours following the head injury in most of cases, though more than 4 days later in a small number of cases, the appearance of such intracerebral haematomas suggested an unfavourable outcome, cerebral contusion might be a major contributory factor.

Adolescent↗
PubMed1979

Subacute bilateral epidural hematomas in an infant.

Subacute bilateral epidural hematomas in a two-year-old girl are presented. No similar case in this age group has been reported. CT scans may increase the detection of bilateral epidural hematomas in children in the future. The diagnostic and therapeutic characteristics of epidural hematoma in children are discussed.

Age Factors↗
PubMedDate not supplied

An autopsy case of intramedullary venous malformation of the spinal cord with spreading hematomyelia.

A 23-year-old Japanese woman experienced sudden severe shoulder pain, and subsequently died of cardiorespiratory arrest after an 8-day course of illness. Autopsy revealed a venous malformation in the spinal cord at the C6 level with fresh massive hemorrhage showing widespread rostrocaudal extension. The upper limit of the hemorrhage was in the left gracile nucleus of the medulla oblongata, and the lower limit was in the left posterior horn of the spinal cord at L4. The hemorrhage extended through the spinal cord, involving the left posterior horn and intermediate zone of the gray matter and the ventral part of the posterior funiculus. The mechanism of the extension of the hemorrhage and the pathogenesis of the spinal venous malformation are discussed.

Adult↗