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Biomedical subjects

K Hicks

Publications and source records attributed to K Hicks.

79 records · Page 5Linked to original sources
PubMed1982

Blastomycosis.

Blastomycosis is a fungal disease with an endemic area identical to that of histoplasmosis in the United States. Disease states range from a subclinical pulmonary illness to a rapidly progressive and fatal disease. Cutaneous lesions are common although the lung is the portal of entry for blastomyces. The organisms are easily demonstrated with potassium hydroxide preparations of fresh sputum, pus from skin lesions, or other biologic material. Skin and serologic tests are unreliable, largely because of cross-reactivity with antigens of histoplasmosis. Because of the ever present potential for milder forms of illness to progress to severe disease, it is recommended that all patients with symptomatic or culture proven disease be treated with amphotericin B.

Adult↗
PubMed1981

Spirometric standards for healthy black adults.

Forced expiratory spirometric studies were performed on 512 nonsmoking black adult men and women with negative cardiorespiratory histories. Regression equations were calculated for forced vital capacity (FVC), percent vital capacity in 1 second (% FEV(1)), and forced midexpiratory flow rate FEF(25-75)%), using height and age. These equations resulted in predicted values 3.5 to 23 percent lower than commonly used standards. The wide range of variation means that a single correction factor is inadequate when considering ethnic differences. In contrast, FEV(1)/FVC was within the accepted range of normal for all ethnic groups. In the 30 percent of subjects in whom sitting height was measured, it was not significantly different from one half the standing height; thus, sitting height is also an inadequate correction factor. Tables of predicted values were constructed for easy reference, with the hope that use of racespecific standards for pulmonary function testing will become widespread.

Adult↗
PubMed1980

Necrosis of the tongue secondary to cranial arteritis.

Two elderly women presented with ischaemic necrosis of the tongue. In both there were typical features of cranial arteritis. The importance of early recognition is emphasised so that appropriate therapy may be prescribed to minimise further complications.

Aged↗
PubMed1977

Characterization and synthesis of volatile compounds from the defensive secretions of some "daddy longlets" (Arachnida: Opiliones: Leiobunum spp.).

Analyses of the chief volatile constituents of the defensive secretions of three oplionids were carried out. Leiobunum nigripalpi produces three closely related C7 compounds: E-4-methyl-4-hexen-3-one(I), 4-methylhexan-3-one(II), and 4-methylhexan-3-ol(III), along with E-4-methyl-4-hepten-3-one(IV), E,E-2,4-dimethylhexa-2,4-dienal(IX), and a minor, unidentified component. L. leiopenis secretion contains E-4-methyl-4-hepten-3-one(IV), 4-methylheptan-3-one(V), E,E-2,4-dimethylhexa-2,4-dien-1-ol(VII), and E,E-2,4-dimethylhepta-2,4-dien-1-ol(VIII). L. calcar yields chiefly E-4,6-dimethyl-6-octen-3-one(VI) and E,E-2,4-dimethylhexa-2,4-dien-1-ol(VII). Six of these compounds are new natural products. The structures of these compounds, which can be regarded either as polyketide-derived or as modified isoprenoids, raise interesting biosynthetic questions.

Alcohols↗
PubMed1977

New methylcyclopentanoid terpenes from the larval defensive secretion of a chrysomelid beetle (Plagiodera versicolora).

The defensive secretion of larvae of the chrysomelid beetle Plagiodera versicolora contains two unstable, volatile methylcyclopentanoid terpenes: a dialdehyde (chrysomelidial) isomeric with dolichodial and anisomorphal, and a closely related enol lactone (plagiolactone). Chrysomelidial and plagiolactone are shown to have structures III and IV on the basis of a detailed analysis of their spectra, coupled with chemical transformations to products of known structure.

Animals↗
PubMed1975

Polyzonimine: A novel terpenoid insect repellent produced by a milliped.

A nitrogen-containing terpene 6,6-dimethyl-2-azaspiro[4.4]non-1-ene (polyzonimine) was isolated from the defensive secretion of the milliped Polyzonium rosalbum. Polyzonimine, which is repellent to such natural enemies of the milliped as ants, acts as a topical irritant to insects (10-4 M induces scratching in cockroaches). Its structure was confirmed by a five-step synthesis starting from 2,2-dimethyl-7-oxabicyclo[4.1.0]heptane.

Animals↗