[25 years of free abortion. Jubilee of abortion law in Denmark].
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Abortion, Induced↗
Biomedical subjects
K Helweg-Larsen
Publications and source records attributed to K Helweg-Larsen.
[Reporting of induced abortions in 1994. A comparison between the data in the Registry of Legally Induced Abortions and the National Patient Registry].
Up to 31st December 1994 all cases of legally induced abortions were notified by the physician responsible for the operation to the National Board of Health and recorded in the Register of Induced Abortions. Following this data, abortion statistics will rely on data concerning induced abortions in the Danish National Patient Register, which includes information based upon the unique personal number of all patients admitted to hospitals. The completeness of the Register of Induced Abortions and the National Patient Register as to induced abortions in 1994 was assessed to evaluate the impact of the change in method of monitoring on trends in the national and regional abortion rate. The complete number of induced abortions was estimated to be the sum of the number recorded in both registers, cases recorded only in the Register of Induced Abortions, cases recorded only in the National Patient Register, and the missing number of registration of induced abortions calculated by capture-recapture methods. Of these 18,429 abortions 96.4% were registered in the National Patient Register and 93.5% in the Register of Induced Abortions. There were some regional variations. In some counties more abortions were registered in the Register of Induced Abortions and in others in the National Patient Register. Considering the change from 1995 in sources of the statistics of induced abortions, analyses of trends in the abortion rate in the early 1990s in Denmark must be evaluated with prudence.
Abortion, Legal↗
Induced abortion and the risk of breast cancer.
BACKGROUND: It has been hypothesized that an interrupted pregnancy might increase a woman's risk of breast cancer because breast cells could proliferate without the later protective effect of differentiation. METHODS: We established a population-based cohort with information on parity and vital status consisting of all Danish women born from April 1, 1935, through March 31, 1978. Through linkage with the National Registry of Induced Abortions, information on the number and dates of induced abortions among those women was combined with information on the gestational age of each aborted fetus. All new cases of breast cancer were identified through linkage with the Danish Cancer Registry. RESULTS: In the cohort of 1.5 million women (28.5 million person-years), we identified 370,715 induced abortions among 280,965 women (2.7 million person-years) and 10,246 women with breast cancer. After adjustment for known risk factors, induced abortion was not associated with an increased risk of breast cancer (relative risk, 1.00; 95 percent confidence interval, 0.94 to 1.06). No increases in risk were found in subgroups defined according to age at abortion, parity, time since abortion, or age at diagnosis of breast cancer. The relative risk of breast cancer increased with increasing gestational age of the fetus at the time of the most recent induced abortion: <7 weeks, 0.81 (95 percent confidence interval, 0.58 to 1.13); 7 to 8 weeks, 1.01 (0.89 to 1.14); 9 to 10 weeks, 1.00 >12 weeks, 1.38 (1.00 to 1.90) (reference category, 9 to 10 weeks). CONCLUSIONS: Induced abortions have no overall effect on the risk of breast cancer.
Abortion, Induced↗
The decline in the incidence of SIDS in Scandinavia and its relation to risk-intervention campaigns. Nordic Epidemiological SIDS Study.
A prospective case-control study of sudden infant death syndrome (SIDS) in Norway, Denmark and Sweden between September 1, 1992 and August 31, 1995 comprised 244 cases and 869 matched controls. After the introduction of risk-intervention campaigns, the SIDS incidence decreased from 2.3/1000 live births in Norway, 1.6 in Denmark and 1.0 in Sweden to 0.6/1000 or fewer in all the Scandinavian countries in 1995. The decrease paralleled a decline in the prone sleeping position and there was an accompanying parallel fall in total postneonatal mortality in all three countries. Thus, the risk-reducing campaigns for SIDS have been successful not only in Norway and Denmark, starting from relatively high incidences, but also in Sweden, starting from a low incidence. During the study period, a gradual increase was observed for the effects of prone sleeping, smoking and bottle-feeding as risk factors for SIDS.
Case-Control Studies↗
Combined effects of sleeping position and prenatal risk factors in sudden infant death syndrome: the Nordic Epidemiological SIDS Study.
OBJECTIVE: Prone sleeping is a strong risk factor for sudden infant death syndrome (SIDS). We investigated whether the combined effect of prone sleeping position and prenatal risk factors further increased the SIDS risk. METHODS: In the Nordic Epidemiological SIDS Study, parents of SIDS victims in Denmark, Norway, and Sweden completed a questionnaire on potential risk factors for SIDS. Forensic pathologists verified the SIDS diagnosis. Four controls of the same gender, age, and place of birth were selected. This matched case-control study, which included 244 SIDS cases and 869 controls from 1992 to 1995, was analyzed by conditional logistic regression. RESULTS: Odds ratios (ORs) for prone and side sleeping compared with supine sleeping for the last sleep were 13.9 (95% confidence interval 8.2-24) and 3.5 (2.1-5.7). Infants 13 to 24 weeks old had particularly high risk in prone and side sleeping, at 28.5 (7.9-107) and 5.9 (1.6-22). OR for prone sleeping was higher in girls, at 30.4 (11-88), than in boys, 10.3 (5.5-19). We found strong combined effects of sleeping position and prenatal risk factors (more than multiplicative). The OR for prone and side sleeping was increased for infants with birth weight <2500 g, at 83 (25-276) and 36.6 (13-107); for preterm infants, at 48.8 (19-128) and 40.5 (14-115); and for intrauterine growth retarded, at 38.8 (14-108) and 9.6 (4.3-22), compared with supine position in infants without these prenatal factors. The combined effect of nonsupine positions and intrauterine growth retarded was highest among 13- to 24-week-old infants. Effects of combined presence of nonsupine sleeping positions and each of the factors of smoking in pregnancy, young maternal age, higher parity, low level of maternal education, and single motherhood were more than additive. Attributable fractions in the population for prone and side sleeping were 18.5% and 26.0%. CONCLUSIONS: Both prone and side sleeping increased the risk of SIDS. The risk was increased further in low birth weight infants, preterm infants, and infants at the age of 13 to 24 weeks, suggesting that SIDS may be triggered by nonsupine sleeping in infants with prenatal risk factors during a vulnerable period of postnatal development.
Age Factors↗
[Perinatal mortality in Denmark. An analysis of development assessed in connection with medically induced abortion during the period 1980-1993].
Based upon data from the Danish National Register of Causes of Deaths, the Birth Register and registers on induced abortions and congenital malformations the article analyses the trend in the Danish perinatal mortality and the impact of abortions induced on medical grounds during the period 1980-1993. Estimating that half of the induced abortions might have led to a perinatal death it is concluded that the perinatal mortality would still have been significantly reduced from the late 1980s to 1990-1993. It is stressed that the impact of induced abortions be included in analyses of trends in perinatal mortality. The perinatal deaths are classified in nine categories by which a grouping into non-avoidable (unexplained intrauterine deaths and deaths due to congenital birth defects) and avoidable deaths (all other categories) was possible. The classification mixed pathoanatomical, obstetrical and paediatric criteria and facilitated an evaluation of the trend in mortality in relation to health care. The recent decrease in the overall perinatal mortality to 7.5 per 1.000 born was both due to a fall in deaths caused by prematurity and in deaths due to congenital birth defects. The deaths due to prematurity were not significantly linked to maternal smoking during pregnancy and no differences could be found in the overall prenatal screening between mothers who lost a baby due to malformations and all mothers.
Abortion, Spontaneous↗
[Infant mortality among children of 35-39 year-old mothers. An analysis of development of death cause categories and among multiple pregnancies during the period 1980-1993].
The perinatal mortality in Denmark decreased significantly from the late 1980's to 1990-1993 but increased among births by mothers aged 35-39 years, from 9.7 in 1985-1989 to 11.0 per 1000 born in 1990-1993. No increase was observed among infants of teen-age mothers or mothers older than 40 years. Based upon data from the Danish National Register of Causes of Death and the Birth Register all perinatal deaths in 1980-1993 were classified in nine categories including pathoanatomical, obstetrical and paediatric criteria. The increase in perinatal mortality in infants born to mothers aged 35-39 years was because of more deaths due to congenital birth defects, intra-partum events and foeto-placental dysfunction, while mortality due to prematurity decreased. The rate of multiple pregnancies and of primiparas increased significantly among 35-39 year-old mothers. With reference to international literature, the article discusses the possible impact of in-vitro fertilisation and other fertility treatments upon the special trend in perinatal mortality in this mother age-group. A national Danish IVF-register was first established in 1994 and will in the future allow concrete analyses of the outcome of IVF-pregnancies.
Adult↗
[Overheating and sudden infant death. Temperature regulation in relation to the prone position, the possible pathogenesis of sudden infant death].
The incidence of sudden infant death syndrome (SIDS) in Denmark varied in the period 1982-1991 between 1.5 and 1.9 per 1000 livebirths. In December 1991 recommendations concerning infants' sleeping position were published by The Danish National Board of Health in order to reduce the risk of SIDS. Babies were recommended to be placed in the supine or side position when sleeping. Parents have followed the guidelines. Most Danish infants are now sleeping on their back or in the side position. Simultaneously, the number of SIDS dropped from about 110 to 40 per year. The incidence decreased to 1.2 in 1992 and was further reduced in 1993 to 0.6 per 1000 live births. Referring to our knowledge of the infant's temperature regulation we discuss why the prone position is a risk factor for SIDS. The head is the site of up to 85% of heat loss in an infant in bed. Placed in the prone position, the infant is more likely to suffer a rise in body temperature, especially if this is combined with having a cold, being heavily wrapped and sleeping in a heated room. Preceding sudden death many infants are reported to have suffered from minor viral infections. These might per se increase the body temperature. Parents often wrap infants that have an infection too heavily, which in an infant sleeping in the prone position might increase the body temperature to a higher level than if sleeping supine. The body temperature influences the production of toxins from normal intestinal flora and from pathogenic bacteria.(ABSTRACT TRUNCATED AT 250 WORDS)
Body Temperature Regulation↗
Definition of the sudden infant death syndrome. Keep current definition.
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Humans↗
[Abortions and prevention of pregnancies in 1992].
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Abortion, Legal↗
Sudden death and human insulin: is there a link?
Case reports from the United Kingdom (UK) in 1989 have suggested that the introduction of human insulin in 1985 was associated with an increased risk of sudden death in insulin-treated diabetic patients. If human insulin increases the risk of sudden death, the number of these should have increased during the period where human insulin was introduced. We therefore identified all cases of sudden death in Denmark in younger insulin-treated diabetic patients, age at death below 50 years. During this period the consumption of human insulin went from 0.2% to 70% of the total consumption in Denmark. The total number of cases fulfilling the inclusion criteria was 226, and the annual number of sudden deaths did not change during the study period (p = 0.14). The number of deaths due to hypoglycaemia and cases with unexplained cause of death also remained constant (test for trend: p = 0.44). Chronic alcohol abuse or acute alcohol intoxication was found in 50% of the 135 patients dying from hypoglycaemia, ketoacidosis or unknown cause of death (including found dead in bed), while this was the case in only 16% of the remaining 91 cases dying from other natural causes. We conclude that introduction of human insulin in Denmark was not followed by an increase in sudden deaths among younger insulin-treated diabetic patients.
Adolescent↗
Sudden natural death in childhood. A review of forensic autopsy protocols in cases of sudden death between the ages of one and five years, 1982-1991, with a special view to sudden unexplained death.
All cases of sudden death of individuals between the ages of one and five years examined at the Forensic Institute, Copenhagen, in a 10-year period were identified to assess the impact of sudden unexplained death in this age group. Of a total of 68 cases, 27 cases were due to accidents, there were 13 cases of homicide, 27 cases were sudden natural deaths and in 1 case the manner of death was uncertain. The autopsy records and histological sections in the 27 cases of natural death were reviewed; the cause of death was not explained in 11 of these cases (40%). Seven cases were previously considered to be caused by infectious disease or aspiration. Criteria for classification are discussed.
Accidents↗
[Sudden, unexplained infant death--sudden infant death syndrome. Forensic pathological aspects].
Delimitation of the sudden unexplained infant death syndrome (SIDS) is difficult as the diagnosis is made by exclusion. The difficulties in the differential diagnosis are concentrated on interpretation of the significance of positive viral and bacterial findings, inflammatory changes in the respiratory organs, heart and central nervous system together with malformations. Classification of SIDS appears, therefore, to vary according to time and place. New techniques, e.g. DNA analysis, have explained the etiology in a few per cent of the cases but have not yet solved the riddle of SIDS. The article reviews hypotheses about apnoea, arrhythmia, overheating and inefficient surveillance of the infant. It is emphasized that assessment of risk factors for SIDS requires valid epidemiological investigations where the basis for the diagnosis is a uniform classification of SIDS infants as compared with other groups of sudden death in infancy. An investigation of this nature has been initiated in the Nordic countries. It is important to examine and treat infants with abnormal sleep apnoea but generalized employment of monitoring has not reduced the number of unexplained infantile deaths.
Autopsy↗
[Significance of sleeping position on the occurrence of sudden, unexplained infant death. An epidemiological review].
The cause of the sudden infant death syndrome (SIDS) is, according to the definition, unknown. Epidemiological research during recent years has identified a series of probable risk factors. One of these is the use of prone position as sleeping position. In the Western European countries, Australia and New Zealand, a total of 14 case-control studies illustrate a possible connection between the prone position and SIDS. Eleven of the studies revealed a significantly increased relative risk (RR) of between 1.4 and 12.5 for SIDS when using the prone position, while the three remaining studies did not demonstrate increased RR. A meta-analysis of the results of the 14 case-control studies showed an RR of 2.4 for SIDS in the prone position as compared with other sleeping positions. In a single prospective cohort study from Australia, an RR of 3.1 was found for SIDS in the prone position. Interventions in which parents are advised not to place the infants in the prone position during sleep appear to have resulted in considerable reduction in the number of cases of SIDS according to preliminary reports from Great Britain, the Netherlands, Norway and New Zealand. A series of methodological problems can be demonstrated in the published results of these studies, including limited size of study populations, inadequate matching of control groups and absent confounder control. Nevertheless, the total epidemiological evidence, also where Denmark is concerned, speaks in favour of altered recommendations for sleeping positions of infants, particularly because there is no documentation to suggest that the prone position offers any advantages to health.(ABSTRACT TRUNCATED AT 250 WORDS)
Australia↗
Sudden infant death syndrome (SIDS) in Denmark: evaluation of the increasing incidence of registered SIDS in the period 1972 to 1983 and results of a prospective study in 1987 through 1988.
To investigate a reported increase, from 0.4 to 1.3 per thousand live births, in the Danish incidence of sudden infant death syndrome (SIDS), a retrospective analysis of SIDS in Denmark from 1972 to 1983 was carried out. Based on data registered with the National Board of Health, a notable regional difference in SIDS rate between the western and eastern parts of Denmark was found. This difference did not correlate with the overall postneonatal mortality by region. Danish law requires medicolegal investigation in all cases of sudden unexpected death. Medicolegal autopsies are performed only in the three forensic institutes which cover all of Denmark. Despite the law and a uniform organization of the forensic medical services, differing application of postmortem examinations and individual interpretation of the history and autopsy in cases of sudden infant death existed. Differences in reporting of respiratory infections, suffocation, and cardiac malformation were found to contribute to the increase and to regional disparities in SIDS incidence. The three Danish forensic institutes examined all cases of sudden infant deaths in Denmark 1987 and 1988. These cases were classified as explained cause of death, pure SIDS, and atypical SIDS; atypical cases were evaluated by consensus. The SIDS incidence (the number of classic SIDS and atypical SIDS per thousand live births) was 1.9 in 1987 and 1.3 in 1988, and it was identical in the eastern and western part of Denmark; however, a higher incidence both of overall postneonatal and SIDS mortality was found in the middle region of Denmark.(ABSTRACT TRUNCATED AT 250 WORDS)
Autopsy↗
[Psychological sequelae of rape--can they be reduced?].
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Anxiety Disorders↗
[The validity of the perinatal classification by the Health Department].
On the basis of 273 perinatal and neonatal deaths in three Danish counties in 1985 and 1986, the validity of the abbreviated classification of perinatal deaths by the National Board of Health which comprises six categories was assessed. The classification is relatively robust regarding incorrect classification of International Classification of Diseases (ICD) as 87% of the deaths were classified in the relevant categories. This may be because the classification is relatively rough but also because the classification, as regards ICD diagnoses, is based on information from the register of births.
Cause of Death↗